Results 31 to 40 of about 22,190 (186)

RIP3 attenuates the pancreatic damage induced by deletion of ATG7 [PDF]

Cell Death & Disease, 2017
AbstractInvalidation of pancreatic autophagy entails pancreatic atrophy, endocrine and exocrine insufficiency and pancreatitis. The aim of this study was to investigate whether depletion of Rip3, which is involved in necroptotic signaling, may attenuate the pancreatic atrophy and pancreatitis resulting from autophagy inhibition.
Xiaodong Zhou, Li Xie, Leizhou Xia, Frank Bergmann, Markus W Büchler, Guido Kroemer, Thilo Hackert, Franco Fortunato   +7 more
openaire   +3 more sources

Characterization of Corneal Defects in ATG7-Deficient Mice. [PDF]

Int J Mol Sci
Regulated proteolysis via autophagy is essential for cellular homeostasis, yet the specific role of autophagy-related gene 7 (ATG7) in corneal epithelial maintenance remains unclear. Using a conditional knockout mouse model (Atg7f/f K14Cre+/−), we investigated the impact of ATG7 deficiency on corneal epithelial autophagy, morphology, and vascular ...
Volatier T, Mourier A, Mann J, Meshko B, Hadrian K, Cursiefen C, Notara M.   +6 more
europepmc   +4 more sources

Sevoflurane up-regulates miR-7a to protect against ischemic brain injury in rats by down-regulating ATG7 and reducing neuronal autophagy

Brain Research Bulletin, 2022
The current study aimed to elucidate the effects of Sevoflurane on neuronal autophagy and ischemic brain injury by regulating miR-7a/ATG7 axis. The rat model of middle cerebral artery occlusion (MCAO) was established by thread embolization.
Zhiguo Wu, Jian Tan, Lichang Lin, Wenting Zhang, Wanqiu Yuan   +4 more
doaj   +1 more source

Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7 [PDF]

Molecular Cell, 2011
E1 enzymes activate ubiquitin-like proteins and transfer them to cognate E2 enzymes. Atg7, a noncanonical E1, activates two ubiquitin-like proteins, Atg8 and Atg12, and plays a crucial role in autophagy. Here, we report crystal structures of full-length Atg7 and its C-terminal domain bound to Atg8 and MgATP, as well as a solution structure of Atg8 ...
Noda, Nobuo N., Satoo, Kenji, Fujioka, Yuko, Kumeta, Hiroyuki, Ogura, Kenji, Nakatogawa, Hitoshi, Ohsumi, Yoshinori, Inagaki, Fuyuhiko   +7 more
openaire   +2 more sources

A short isoform of ATG7 fails to lipidate LC3/GABARAP [PDF]

Scientific Reports, 2018
AbstractAutophagy is a degradation pathway important for cellular homeostasis. The E1-like enzyme ATG7 is a key component of the autophagy machinery, with the main function of mediating the lipidation of LC3/GABARAP during autophagosome formation. By analysing mRNA-sequencing data we found that in addition to the full-length ATG7 isoform, various ...
Ogmundsdottir, MH, Fock, Valerie, Sooman, L, Pogenberg, V, Dilshat, R, Bindesbøll, Christian, Ögmundsdóttir, Helga, Simonsen, Anne, Wilmanns, Matthias, Steingrimsson, E   +9 more
openaire   +4 more sources

Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans

New England Journal of Medicine, 2021
Autophagy is the major intracellular degradation route in mammalian cells. Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or perinatal lethality, and conditional models show neurodegeneration. Impaired autophagy has been associated with a range of complex human diseases, yet congenital autophagy disorders are rare.We
Collier, Jack, Guissart, Claire, Oláhová, Monika, Sasorith, Souphatta, Piron-Prunier, Florence, Suomi, Fumi, Zhang, David, Martinez-Lopez, Nuria, Leboucq, Nicolas, Bahr, Angela, Azzarello-Burri, Silvia, Reich, Selina, Schöls, Ludger, Polvikoski, Tuomo, Meyer, Pierre, Larrieu, Lise, Schaefer, Andrew, Alsaif, Hessa, Alyamani, Suad, Zuchner, Stephan, Barbosa, Inês, Deshpande, Charu, Pyle, Angela, Rauch, Anita, Synofzik, Matthis, Alkuraya, Fowzan, Rivier, Francois, Ryten, Mina, Mcfarland, Robert, Delahodde, Agnès, Mcwilliams, Thomas, Koenig, Michel, Taylor, Robert   +32 more
openaire   +6 more sources

Lower ATG7 Levels are Associated with a Higher Risk of Gestational Diabetes Mellitus: A Cross-Sectional Study

Diabetes, Metabolic Syndrome and Obesity, 2022
Ling Lu,1 Yan Ma,2 Jie Deng,1 Jiaqiong Xie,1 Chaolin Huang1 1Department of Gynaecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Obstetrics, The First Affiliated Hospital of Chengdu ...
Lu L, Ma Y, Deng J, Xie J, Huang C
doaj  

ATG7 immunohistochemical expression in malignant pleural mesothelioma. A preliminary report.

Histology and histopathology, 2021
Literature evidence has demonstrated a high incidence of asbestos-related malignant pleural mesothelioma (MPM) in a Sicilian town (Biancavilla, Italy), where fluoro-edenite (FE) fibers were discovered some decades ago. As ATG7 immunohistochemical analysis has been ascribed as a prognostic tool of improved survival, we decided to investigate, in MPM ...
Rapisarda, Venerando, Broggi, Giuseppe, Caltabiano, Rosario, Lombardo, Claudia, Castorina, Sergio, Trovato, Angela, Ledda, Caterina, Filetti, Veronica, Loreto, Carla   +8 more
openaire   +4 more sources

Lysosome Dysfunction Triggers Atg7-dependent Neural Apoptosis [PDF]

Journal of Biological Chemistry, 2010
Macroautophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged organelles are sequestered and degraded via the lysosome. Alterations in autophagy-associated proteins have been shown to cause neural tube closure defects, neurodegeneration, and tumor formation.
Ken C, Walls, Arindam P, Ghosh, Aimee V, Franklin, Barbara J, Klocke, Mary, Ballestas, John J, Shacka, Jianhua, Zhang, Kevin A, Roth   +7 more
openaire   +2 more sources

Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force

Open Medicine
Autophagy serves as a protective mechanism in response to mechanical stress during OTM. However, the role of ATG7, a key regulatory gene in autophagy, in modulating periodontium remodeling during OTM remains unclear.
Yang Zhenjin, Chen Mingzhu, Liao Xianmin, Ma Liya, Liang Cun, Li Yanjie, Hu Jiangtian   +6 more
doaj   +1 more source