Results 31 to 40 of about 31,821 (205)
Biomolecules, 2019 Many studies have focused on how autophagy plays an important role in intestinal homeostasis under pathological conditions. However, its role in the intestine during hibernation remains unclear.
Waseem Ali Vistro +9 more
doaj +1 more source
CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1 [PDF]
, 2018 Macroautophagy/autophagy is an important intracellular mechanism for the maintenance of cellular homeostasis. Here we show that the CERKL (ceramide kinase like) gene, a retinal degeneration (RD) pathogenic gene, plays a critical role in regulating ...
Danna Jia +21 more
core +2 more sources
Metformin protects against abdominal aortic aneurysm by Atg7-induced autophagy [PDF]
Advances in Clinical and Experimental Medicine, 2021 Abdominal aortic aneurysm (AAA) is a pathological dilation of the abdominal aorta. It is often asymptomatic, yet it has a high susceptibility to rupture. Our previous study showed that metformin protected against the pathophysiology of AAA by reducing the activation of the PI3K/AKT/mTOR pathway.To investigate the potential involvement of the autophagy ...
Jingjing Guo +7 more
openaire +2 more sources
Acta Veterinaria, 2017 Induced prenatal hypothyroidism in rat pups leads to accelerated primordial follicle assembly and premature follicular atresia with ovary failure. This work investigates the influence of maternal hypothyroidism induced with 6-n-propyl-2-thyouracil (PTU ...
Danilović Luković Jelena +6 more
doaj +1 more source
Knockdown of Atg7 suppresses Tumorigenesis in a murine model of liver cancer
Translational Oncology, 2021 Hepatocellular Carcinoma (HCC) is the most common type of primary liver cancer in adults and a leading cause of cancer-related deaths worldwide. Studies have shown that autophagy is significantly involved in carcinogenesis, in particular, driven by ...
Kyung Joo Cho +4 more
doaj +1 more source
Connexins : substrates and regulators of autophagy [PDF]
, 2016 Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems.
Bultynck, Geert +4 more
core +1 more source
E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I [PDF]
, 2013 p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified.
C Stumptner +24 more
core +9 more sources
Essential role of ATG7 in LPS-induced endometrial inflammatory injury in goats
Animal Diseases, 2023 The economic losses caused by uterine infections in ruminants have received increasing attention. Autophagy-related 7 (ATG7) has been demonstrated to be capable of regulating apoptosis, but surprisingly, ATG7 can both promote and inhibit apoptosis in ...
Tingting Jiang +2 more
doaj +1 more source
Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity [PDF]
, 2014 During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis.
Debnath, Jayanta +8 more
core +4 more sources
The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer. [PDF]
, 2015 While carcinoma of the prostate is the second most common cause of cancer death in the US, current methods and markers used to predict prostate cancer (PCa) outcome are inadequate.
Benner, Christopher +2 more
core +5 more sources