Results 11 to 20 of about 22,190 (186)

Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62

Scientific Reports, 2022
Autophagy is a housekeeping mechanism tasked with eliminating misfolded proteins and damaged organelles to maintain cellular homeostasis. Autophagy deficiency results in increased oxidative stress, DNA damage and chronic cellular injury.
Stephanie U. Greer, Jiamin Chen, Margret H. Ogmundsdottir, Carlos Ayala, Billy T. Lau, Richard Glenn C. Delacruz, Imelda T. Sandoval, Sigrun Kristjansdottir, David A. Jones, Derrick S. Haslem, Robin Romero, Gail Fulde, John M. Bell, Jon G. Jonasson, Eirikur Steingrimsson, Hanlee P. Ji, Lincoln D. Nadauld   +16 more
doaj   +3 more sources

Knockdown of Atg7 suppresses Tumorigenesis in a murine model of liver cancer

Translational Oncology, 2021
Hepatocellular Carcinoma (HCC) is the most common type of primary liver cancer in adults and a leading cause of cancer-related deaths worldwide. Studies have shown that autophagy is significantly involved in carcinogenesis, in particular, driven by ...
Kyung Joo Cho, Sun Yeong Shin, Hyuk Moon, Beom Kyung Kim, Simon Weonsang Ro   +4 more
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Identification of ATG7 as a protein ATG8ylation substrate

Cell Reports
Summary: Protein ATG8ylation is a post-translational modification where ubiquitin-like protein LC3/ATG8 forms covalent conjugation with cellular proteins, a process reversed by ATG4.
Huazhong Xie, Jiahui Long, Yijun Huang, Yao Wang, Peiqing Liu, Min Li   +5 more
doaj   +3 more sources

Role of ATG7-dependent non-autophagic pathway in angiogenesis

Frontiers in Pharmacology
ATG7, one of the core proteins of autophagy, plays an important role in various biological processes, including the regulation of autophagy. While clear that autophagy drives angiogenesis, the role of ATG7 in angiogenesis remains less defined.
Jinxiang Chen, Jinxiang Chen, Jinxiang Chen, Yu Liang, Shaorun Hu, Shaorun Hu, Shaorun Hu, Jun Jiang, Jun Jiang, Min Zeng, Mao Luo, Mao Luo, Mao Luo   +12 more
doaj   +3 more sources

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures [PDF]

Nature Structural & Molecular Biology, 2012
Core functions of autophagy are mediated by ubiquitin-like protein (UBL) cascades, in which a homodimeric E1 enzyme, Atg7, directs the UBLs Atg8 and Atg12 to their respective E2 enzymes, Atg3 and Atg10. Crystallographic and mutational analyses of yeast (Atg7-Atg3)(2) and (Atg7-Atg10)(2) complexes reveal noncanonical, multisite E1-E2 recognition in ...
Kaiser, Stephen E., Mao, Kai, Taherbhoy, Asad M., Yu, Shanshan, Olszewski, Jennifer L., Duda, David M., Kurinov, Igor, Deng, Alan, Fenn, Timothy D., Klionsky, Daniel J., Schulman, Brenda A.   +10 more
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Long non-coding RNAs LINC00689 inhibits the apoptosis of human nucleus pulposus cells via miR-3127-5p/ATG7 axis-mediated autophagy

Open Medicine, 2022
This study aimed to explore the effects of long non-coding RNAs LINC00689 (LINC00689) in human nucleus pulposus cells (NPCs). NPCs were isolated and their morphology was observed.
Wang Changsheng, Chen Rongsheng, Zhu Xitian, Zhang Xiaobo   +3 more
doaj   +1 more source

Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1 [PDF]

Autophagy, 2013
Central to most forms of autophagy are two ubiquitin-like proteins (UBLs), Atg8 and Atg12, which play important roles in autophagosome biogenesis, substrate recruitment to autophagosomes, and other aspects of autophagy. Typically, UBLs are activated by an E1 enzyme that (1) catalyzes adenylation of the UBL C terminus, (2) transiently covalently ...
Stephen E, Kaiser, Yu, Qiu, Julie E, Coats, Kai, Mao, Daniel J, Klionsky, Brenda A, Schulman   +5 more
openaire   +2 more sources

Myricitrin from Physalis pubescens L. leaves and frankincense decrease resistance of MCF-7 cells and ameliorate efficacy of epirubicin. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: It was found that flavonoids and frankincense exert anti-cancer effect through their antioxidant and anti-inflammatory activities. Aims: To evaluate the cytotoxic effect against MCF-7 cells of flavonoids isolated from Physalis pubescens L ...
Suzy Abd El-Hakeem El-Sherbeni, Ghada Mohammad Al-Ashmawy   +1 more
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ATG7 upregulation contributes to malignant transformation of human bronchial epithelial cells by B[a]PDE via DNMT3B protein degradation and miR-494 promoter methylation

Ecotoxicology and Environmental Safety, 2023
Lung cancer primarily arises from exposure to various environmental factors, particularly airborne pollutants. Among the various lung carcinogens, benzo(a)pyrene and its metabolite B[a]PDE are the strongest ones that actively contribute to lung cancer ...
Zhongxian Tian, Xiaohui Hua, Junlan Zhu, Peiwei Li, Ruifan Chen, Xin Li, Tengda Li, Chengfan Zhou, Chuanshu Huang   +8 more
doaj   +1 more source

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy [PDF]

Nature Communications, 2018
AbstractMacroautophagy (autophagy) is a crucial cellular stress response for degrading defective macromolecules and organelles, as well as providing bioenergetic intermediates during hypoxia and nutrient deprivation. Here we report a thiol-dependent process that may account for impaired autophagy during aging.
Frudd, Karen, Burgoyne, Tomas, Burgoyne, Joe   +2 more
openaire   +6 more sources