Results 11 to 20 of about 25,612 (182)

ATG7 safeguards human neural integrity

, 2021
\ua9 2021 Informa UK Limited, trading as Taylor & Francis Group. ATG7 drives macroautophagy, hereafter “autophagy”, by generating ATG12–ATG5 conjugates and lipidating Atg8 homologs including LC3.
Collier JJ, Taylor RW, Olahova M, McWilliams TG   +3 more
core   +4 more sources

The role of autophagy in the Arabidopsis self-incompatible pollen rejection response

Autophagy Reports, 2022
In plants, macroautophagy/autophagy is an essential mechanism responsible for a large variety of processes throughout the plant’s lifecycle, including nutrient processing, immunity, stress responses and senescence.
Stuart R. Macgregor, Daphne R. Goring
doaj   +1 more source

Long non-coding RNAs LINC00689 inhibits the apoptosis of human nucleus pulposus cells via miR-3127-5p/ATG7 axis-mediated autophagy

Open Medicine, 2022
This study aimed to explore the effects of long non-coding RNAs LINC00689 (LINC00689) in human nucleus pulposus cells (NPCs). NPCs were isolated and their morphology was observed.
Wang Changsheng, Chen Rongsheng, Zhu Xitian, Zhang Xiaobo   +3 more
doaj   +1 more source

ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation

, 2022
Macroautophagy/autophagy is a conserved cellular mechanism to degrade unneeded cytoplasmic proteins and organelles to recycle their components, and it is critical for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming.
Jilong Zhou (9090269), Hainan He (12265937), Wen-Jing Xiong (3430814), Jun-Ming Tang (291505), Jing-Jing Zhang (182712), Tian Xu (191516), Chengyu Li (818338), Qiao Li (571252), Yi-Liang Miao (249891), Xia Zhang (41398), Wang Yao (747677), Shu-Yuan Yin (12265940), Zhouyiyuan Xue (12265952), Dan-Ya Wu (12265943), Cheng-Li Dou (12265946), Jiani Xiang (12265949), Xin Liu (43569), Li-Yan Wang (1989328)   +17 more
core   +1 more source

Myricitrin from Physalis pubescens L. leaves and frankincense decrease resistance of MCF-7 cells and ameliorate efficacy of epirubicin. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: It was found that flavonoids and frankincense exert anti-cancer effect through their antioxidant and anti-inflammatory activities. Aims: To evaluate the cytotoxic effect against MCF-7 cells of flavonoids isolated from Physalis pubescens L ...
Suzy Abd El-Hakeem El-Sherbeni, Ghada Mohammad Al-Ashmawy   +1 more
doaj  

Anti-tumor immunity influences cancer cell reliance upon ATG7

OncoImmunology, 2020
Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it has been shown to inhibit, promote
Michael D. Arensman, Xiaoran S. Yang, Wenyan Zhong, Stephanie Bisulco, Erik Upeslacis, Edward C. Rosfjord, Shibing Deng, Robert T. Abraham, Christina H. Eng   +8 more
doaj   +1 more source

ATG7 upregulation contributes to malignant transformation of human bronchial epithelial cells by B[a]PDE via DNMT3B protein degradation and miR-494 promoter methylation

Ecotoxicology and Environmental Safety, 2023
Lung cancer primarily arises from exposure to various environmental factors, particularly airborne pollutants. Among the various lung carcinogens, benzo(a)pyrene and its metabolite B[a]PDE are the strongest ones that actively contribute to lung cancer ...
Zhongxian Tian, Xiaohui Hua, Junlan Zhu, Peiwei Li, Ruifan Chen, Xin Li, Tengda Li, Chengfan Zhou, Chuanshu Huang   +8 more
doaj   +1 more source

Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62

Scientific Reports, 2022
Autophagy is a housekeeping mechanism tasked with eliminating misfolded proteins and damaged organelles to maintain cellular homeostasis. Autophagy deficiency results in increased oxidative stress, DNA damage and chronic cellular injury.
Stephanie U. Greer, Jiamin Chen, Margret H. Ogmundsdottir, Carlos Ayala, Billy T. Lau, Richard Glenn C. Delacruz, Imelda T. Sandoval, Sigrun Kristjansdottir, David A. Jones, Derrick S. Haslem, Robin Romero, Gail Fulde, John M. Bell, Jon G. Jonasson, Eirikur Steingrimsson, Hanlee P. Ji, Lincoln D. Nadauld   +16 more
doaj   +1 more source

Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans [PDF]

, 2021
BACKGROUND: Autophagy is the major intracellular degradation route in mammalian cells. Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or perinatal lethality, and conditional models show neurodegeneration.
Schaefer, AM, Schöls, L, Zuchner, S, Bahr, A, Polvikoski, TM, Collier, JJ, Larrieu, L, Delahodde, A, Sasorith, S, Alkuraya, FS, Koenig, M, Leboucq, N, Meyer, P, Reich, S, Guissart, C, Rauch, A, McWilliams, TG, Ryten, M, Pyle, A, Taylor, RW, Piron-Prunier, F, Barbosa, IA, Oláhová, M, Martinez-Lopez, N, Rivier, F, Zhang, D, Alsaif, HS, Synofzik, M, Azzarello-Burri, S, Suomi, F, Deshpande, C, Alyamani, S, McFarland, R   +32 more
core   +5 more sources

In Vivo Autophagy Up-Regulation of Small Intestine Enterocytes in Chinese Soft-Shelled Turtles during Hibernation

Biomolecules, 2019
Many studies have focused on how autophagy plays an important role in intestinal homeostasis under pathological conditions. However, its role in the intestine during hibernation remains unclear.
Waseem Ali Vistro, Yue Zhang, Xuebing Bai, Ping Yang, Yufei Huang, Wenjia Qu, Abdul Sattar Baloch, Ruizhi Wu, Imran Tarique, Qiusheng Chen   +9 more
doaj   +1 more source