Results 11 to 20 of about 31,821 (205)

Anti-tumor immunity influences cancer cell reliance upon ATG7 [PDF]

OncoImmunology, 2020
Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it has been shown to inhibit, promote
Michael D. Arensman, Xiaoran S. Yang, Wenyan Zhong, Stephanie Bisulco, Erik Upeslacis, Edward C. Rosfjord, Shibing Deng, Robert T. Abraham, Christina H. Eng   +8 more
doaj   +3 more sources

Role of ATG7-dependent non-autophagic pathway in angiogenesis

Frontiers in Pharmacology
ATG7, one of the core proteins of autophagy, plays an important role in various biological processes, including the regulation of autophagy. While clear that autophagy drives angiogenesis, the role of ATG7 in angiogenesis remains less defined.
Jinxiang Chen, Jinxiang Chen, Jinxiang Chen, Yu Liang, Shaorun Hu, Shaorun Hu, Shaorun Hu, Jun Jiang, Jun Jiang, Min Zeng, Mao Luo, Mao Luo, Mao Luo   +12 more
doaj   +3 more sources

Uba1 functions in Atg7- and Atg3-independent autophagy [PDF]

Nature Cell Biology, 2013
Autophagy is a conserved process that delivers components of the cytoplasm to lysosomes for degradation. The E1 and E2 enzymes encoded by Atg7 and Atg3 are thought to be essential for autophagy involving the ubiquitin-like protein Atg8. Here, we describe
Baehrecke, Eric H., Chang, Tsun-Kai, Harper, J. Wade, Hayes, Sebastian D., Powers, Christine M., Shravage, Bhupendra V., Simin, Rachel T.   +6 more
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Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity

International Journal of Molecular Sciences, 2023
The autophagy gene ATG7 has been shown to be essential for the induction of autophagy, a process that used to be suppressed in nonalcoholic fatty liver disease (NAFLD). However, the specific role of ATG7 in NAFLD remains unclear. The aim of this study was to analyze hepatic ATG7 mRNA and ATG7 protein expression regarding obesity-associated NAFLD ...
Andrea Barrientos-Riosalido, Monica Real, Laia Bertran, Carmen Aguilar, Salomé Martínez, David Parada, Margarita Vives, Fàtima Sabench, David Riesco, Daniel Del Castillo, Cristóbal Richart, Teresa Auguet   +11 more
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Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures [PDF]

Nature Structural & Molecular Biology, 2012
Core functions of autophagy are mediated by ubiquitin-like protein (UBL) cascades, in which a homodimeric E1 enzyme, Atg7, directs the UBLs Atg8 and Atg12 to their respective E2 enzymes, Atg3 and Atg10. Crystallographic and mutational analyses of yeast (Atg7-Atg3)(2) and (Atg7-Atg10)(2) complexes reveal noncanonical, multisite E1-E2 recognition in ...
Kaiser, Stephen E., Mao, Kai, Taherbhoy, Asad M., Yu, Shanshan, Olszewski, Jennifer L., Duda, David M., Kurinov, Igor, Deng, Alan, Fenn, Timothy D., Klionsky, Daniel J., Schulman, Brenda A.   +10 more
openaire   +2 more sources

Long non-coding RNAs LINC00689 inhibits the apoptosis of human nucleus pulposus cells via miR-3127-5p/ATG7 axis-mediated autophagy

Open Medicine, 2022
This study aimed to explore the effects of long non-coding RNAs LINC00689 (LINC00689) in human nucleus pulposus cells (NPCs). NPCs were isolated and their morphology was observed.
Wang Changsheng, Chen Rongsheng, Zhu Xitian, Zhang Xiaobo   +3 more
doaj   +1 more source

Lysosome Dysfunction Triggers Atg7-dependent Neural Apoptosis [PDF]

Journal of Biological Chemistry, 2010
Macroautophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged organelles are sequestered and degraded via the lysosome. Alterations in autophagy-associated proteins have been shown to cause neural tube closure defects, neurodegeneration, and tumor formation.
Ken C, Walls, Arindam P, Ghosh, Aimee V, Franklin, Barbara J, Klocke, Mary, Ballestas, John J, Shacka, Jianhua, Zhang, Kevin A, Roth   +7 more
openaire   +2 more sources

Atg7 Knockdown Reduces Chemerin Secretion in Murine Adipocytes [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2019
Abstract Context In individuals with obesity, adipocyte endocrine function is affected by altered autophagy. Genetic variants in autophagy-related gene 7 (ATG7) correlated with serum chemerin (RARRES2) concentrations.
Sascha Heinitz, Claudia Gebhardt, Paolo Piaggi, Jacqueline Krüger, Henrike Heyne, Juliane Weiner, John T Heiker, Michael Stumvoll, Matthias Blüher, Leslie Baier, Assaf Rudich, Peter Kovacs, Anke Tönjes   +12 more
openaire   +3 more sources

Myricitrin from Physalis pubescens L. leaves and frankincense decrease resistance of MCF-7 cells and ameliorate efficacy of epirubicin. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: It was found that flavonoids and frankincense exert anti-cancer effect through their antioxidant and anti-inflammatory activities. Aims: To evaluate the cytotoxic effect against MCF-7 cells of flavonoids isolated from Physalis pubescens L ...
Suzy Abd El-Hakeem El-Sherbeni, Ghada Mohammad Al-Ashmawy   +1 more
doaj  

The proppin Bcas3 and its interactor KinkyA localize to the early phagophore and regulate autophagy [PDF]

, 2021
To resolve the signaling mechanisms that mediate the starvation-induced processes of Dictyostelium sporulation and encystation, we performed insertional mutagenesis on cells harboring an mRFP-tagged spore gene.
Schaap, Pauline, Yamada, Yoko
core   +2 more sources