Emerging roles of ATG7 in human health and disease [PDF]
EMBO Molecular Medicine, 2021 The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG) proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is paradigmatic of studying autophagy deficiency, yet emerging data suggest that ATG ...
Jack J Collier +2 more
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Inhibition of ATG7 promotes orthodontic tooth movement by regulating the RANKL/OPG ratio under compression force [PDF]
Open MedicineAutophagy serves as a protective mechanism in response to mechanical stress during OTM. However, the role of ATG7, a key regulatory gene in autophagy, in modulating periodontium remodeling during OTM remains unclear.
Yang Zhenjin +6 more
doaj +2 more sources
ATG7-induced autophagy inhibits ferroptosis and promotes the progression of colorectal adenocarcinoma [PDF]
Discover OncologyPurpose To investigate the role of ATG7-induced autophagy in regulating ferroptosis and promoting the progression of colorectal adenocarcinoma (COAD). Method The UALCAN database was used to predict the expression of ATG7 and its prognosis significance in
Minyuan Chen +3 more
doaj +2 more sources
Atg7 in CD4+ T cells improves intestinal mucosal inflammation by regulating Ets1‐mediated T cell differentiation [PDF]
Clinical and Translational MedicineBackground Atg7‐autophagy–related gene 7 contributes as an immune cell function regulator, particularly involved in CD4⁺ T cell response. Nevertheless, the specific contribution of Atg7 in CD4⁺ T cells sensitive immune responses in inflammatory bowel ...
Yue‐Tao Zhou +15 more
doaj +2 more sources
ATG7-driven mitophagy in BMSC@CS hydrogel reprograms metabolism to boost bone regeneration [PDF]
Materials Today BioBone regeneration remains a formidable challenging due to impaired energy metabolism and the limited osteogenic potential of transplanted stem cells. Mitochondrial homeostasis orchestrates osteogenesis, with mitophagy maintaining the metabolic rhythm ...
Qiumei Lan +17 more
doaj +2 more sources
ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections [PDF]
Nature CommunicationsInfections caused by nontuberculous mycobacteria, such as Mycobacterium avium and Mycobacteroides abscessus, are becoming increasingly prevalent, and rising antibiotic resistance poses a significant clinical challenge.
Sang Min Jeon +21 more
doaj +2 more sources
Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36 [PDF]
Open Biology, 2016 Cardiovascular disease (CVD) is the leading cause of the death worldwide. An increasing number of studies have found that autophagy is involved in the progression or prevention of CVD.
Shiguo Li +11 more
doaj +1 more source
The role of autophagy in the Arabidopsis self-incompatible pollen rejection response
Autophagy Reports, 2022 In plants, macroautophagy/autophagy is an essential mechanism responsible for a large variety of processes throughout the plant’s lifecycle, including nutrient processing, immunity, stress responses and senescence.
Stuart R. Macgregor, Daphne R. Goring
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A novel region within a conserved domain in ATG7 emerged in vertebrates
Autophagy Reports, 2022 The E1-like enzyme ATG7 belongs to a group of ATG proteins that mediate the autophagy process. Autophagy is a highly conserved degradation pathway important for maintaining homeostasis in eukaryotic cells.
Valgerdur J. Hjaltalin +4 more
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Aquaculture and Fisheries, 2022 The high mortality in larval-to-juvenile transition is a big problem in aquaculture which is related to the shifting from endogenous to exogenous feeding. However, the underlying causes remain poorly understood.
Suzan Attia Mawed +4 more
doaj +1 more source