ATG7 Limits Basal Antiviral Gene Expression and Moderately Promotes VSV Replication in Mammalian Non-Immune Cells [PDF]
PathogensThe autophagy regulator ATG7 helps maintain cellular homeostasis and has been suggested to modulate aspects of antiviral immune responses. In Drosophila, ATG7-dependent autophagy contributes to host resistance to vesicular stomatitis virus (VSV), a ...
Xiaohan Tong +7 more
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Emerging roles of ATG7 in human health and disease
EMBO Molecular Medicine, 2021 The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG) proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is paradigmatic of studying autophagy deficiency, yet emerging data suggest that ATG ...
Jack J Collier +2 more
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ATG7 vs. ATG5: Distinct autophagy pathways shaping TGF-β signaling and endothelial function. [PDF]
PLoS ONEAutophagy and transforming growth factor-beta (TGF-β) signaling are critical cellular processes that maintain homeostasis and regulate various physiological functions, including endothelial cell function.
Aman Singh +4 more
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ATG7-induced autophagy inhibits ferroptosis and promotes the progression of colorectal adenocarcinoma [PDF]
Discover OncologyPurpose To investigate the role of ATG7-induced autophagy in regulating ferroptosis and promoting the progression of colorectal adenocarcinoma (COAD). Method The UALCAN database was used to predict the expression of ATG7 and its prognosis significance in
Minyuan Chen +3 more
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ATG7-driven mitophagy in BMSC@CS hydrogel reprograms metabolism to boost bone regeneration [PDF]
Materials Today BioBone regeneration remains a formidable challenging due to impaired energy metabolism and the limited osteogenic potential of transplanted stem cells. Mitochondrial homeostasis orchestrates osteogenesis, with mitophagy maintaining the metabolic rhythm ...
Qiumei Lan +17 more
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Blm10/PA200-Activated 20S Proteasomes Promote α-Synuclein Degradation and Bypass Proteasome Inhibition in Parkinson's Disease Models. [PDF]
Aging CellThis study demonstrates that α‐synuclein expression stabilizes the proteasome activator Blm10, thereby linking α‐synuclein stress to changes in proteasome composition. Blm10/PA200‐capped 20S proteasomes efficiently degrade both monomeric and oligomeric α‐synuclein and remain resistant to α‐synuclein‐induced inhibition.
Ali TT +7 more
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Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36 [PDF]
Open Biology, 2016 Cardiovascular disease (CVD) is the leading cause of the death worldwide. An increasing number of studies have found that autophagy is involved in the progression or prevention of CVD.
Shiguo Li +11 more
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The role of autophagy in the Arabidopsis self-incompatible pollen rejection response
Autophagy Reports, 2022 In plants, macroautophagy/autophagy is an essential mechanism responsible for a large variety of processes throughout the plant’s lifecycle, including nutrient processing, immunity, stress responses and senescence.
Stuart R. Macgregor, Daphne R. Goring
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A novel region within a conserved domain in ATG7 emerged in vertebrates
Autophagy Reports, 2022 The E1-like enzyme ATG7 belongs to a group of ATG proteins that mediate the autophagy process. Autophagy is a highly conserved degradation pathway important for maintaining homeostasis in eukaryotic cells.
Valgerdur J. Hjaltalin +4 more
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Aquaculture and Fisheries, 2022 The high mortality in larval-to-juvenile transition is a big problem in aquaculture which is related to the shifting from endogenous to exogenous feeding. However, the underlying causes remain poorly understood.
Suzan Attia Mawed +4 more
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