Results 1 to 10 of about 25,612 (182)

Emerging roles of ATG7 in human health and disease [PDF]

EMBO Molecular Medicine, 2021
The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG) proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is paradigmatic of studying autophagy deficiency, yet emerging data suggest that ATG ...
Jack Collier, Fumi Suomi, Monika Olahova
exaly   +9 more sources

A Hepatocyte-to-Stellate Cell Axis Couples Alternate-Day Fasting to Liver Fibrosis Resolution via ATG7 S-Nitrosylation. [PDF]

Adv Sci (Weinh)
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Wang X, Zeng M, Sun C, Gou Y, Feng Z, Lv W, Yan C, Wu H, Zhang P, Xu J, Cao K, Li H, Ding M, Liu Z, Zhang X, Liu J, Zou X, Feng Z.   +17 more
europepmc   +2 more sources

A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1. [PDF]

Adv Sci (Weinh)
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Xie Q, Zhu Y, Jiang W, Xie H, Li Y, Hu M, Li K, Yu H, Pan Y, Jiang C, Song X, Fan D, Deng B.   +12 more
europepmc   +2 more sources

ATG7 Limits Basal Antiviral Gene Expression and Moderately Promotes VSV Replication in Mammalian Non-Immune Cells [PDF]

Pathogens
The autophagy regulator ATG7 helps maintain cellular homeostasis and has been suggested to modulate aspects of antiviral immune responses. In Drosophila, ATG7-dependent autophagy contributes to host resistance to vesicular stomatitis virus (VSV), a ...
Xiaohan Tong, Ruixue Wang, Yaxin Liu, Malia B. Potts, Shondra M. Pruett-Miller, Michael A. Whitt, Weikuan Gu, Kui Li   +7 more
doaj   +2 more sources

Atg7–Atg12 conjugation and autophagy are negatively regulated by the disordered region of Atg12 [PDF]

Communications Biology
The macroautophagy/autophagy machinery has two ubiquitin-like (UBL) conjugation systems. The Atg8/MAP1LC3/GABARAP (yeast/human) and Atg12/ATG12 proteins are UBL substrates for Atg7/ATG7, a non-canonical E1 enzyme, that thioesterifies its substrates ...
Hana Popelka, Daniel J. Klionsky
doaj   +2 more sources

The potency of native postbiotics and paraprobiotics in modulating inflammation by affecting the gut-kidney axis. [PDF]

Animal Model Exp Med
Native postbiotics and paraprobiotics derived from Lactobacillus and Bifidobacterium strains were administered to dextran sulfate sodium–treated C57BL/6 mice to evaluate their impact on kidney inflammation via the gut–kidney axis. Histological analysis and quantitative polymerase chain reaction of autophagy‐related genes (atg5, atg7, atg12, atg13 ...
Haririzadeh Jouriani F, Torfeh M, Ashrafian F, Rezaie N, Mohammadi M, Aghamohammad S, Rohani M.   +6 more
europepmc   +2 more sources

ATG7 vs. ATG5: Distinct autophagy pathways shaping TGF-β signaling and endothelial function. [PDF]

PLoS ONE
Autophagy and transforming growth factor-beta (TGF-β) signaling are critical cellular processes that maintain homeostasis and regulate various physiological functions, including endothelial cell function.
Aman Singh, Bharatsinai Peddi, Kriti S Bhatt, Hien C Nguyen, Krishna K Singh   +4 more
doaj   +2 more sources

Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36 [PDF]

Open Biology, 2016
Cardiovascular disease (CVD) is the leading cause of the death worldwide. An increasing number of studies have found that autophagy is involved in the progression or prevention of CVD.
Shiguo Li, Chao Liu, Lei Gu, Lina Wang, Yongliang Shang, Qiong Liu, Junyi Wan, Jian Shi, Fang Wang, Zhiliang Xu, Guangju Ji, Wei Li   +11 more
doaj   +1 more source

A novel region within a conserved domain in ATG7 emerged in vertebrates

Autophagy Reports, 2022
The E1-like enzyme ATG7 belongs to a group of ATG proteins that mediate the autophagy process. Autophagy is a highly conserved degradation pathway important for maintaining homeostasis in eukaryotic cells.
Valgerdur J. Hjaltalin, Vivian Pogenberg, Kevin Ostacolo, Arnar Pálsson, Margrét Helga Ogmundsdottir   +4 more
doaj   +1 more source

atg7 and beclin1 are essential for energy metabolism and survival during the larval-to-juvenile transition stage of zebrafish

Aquaculture and Fisheries, 2022
The high mortality in larval-to-juvenile transition is a big problem in aquaculture which is related to the shifting from endogenous to exogenous feeding. However, the underlying causes remain poorly understood.
Suzan Attia Mawed, Jin Zhang, Fan Ren, Yan He, Jie Mei   +4 more
doaj   +1 more source