Results 21 to 30 of about 22,190 (186)
Anti-tumor immunity influences cancer cell reliance upon ATG7
OncoImmunology, 2020 Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it has been shown to inhibit, promote
Michael D. Arensman +8 more
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Uba1 functions in Atg7- and Atg3-independent autophagy [PDF]
Nature Cell Biology, 2013 Autophagy is a conserved process that delivers components of the cytoplasm to lysosomes for degradation. The E1 and E2 enzymes encoded by Atg7 and Atg3 are thought to be essential for autophagy involving the ubiquitin-like protein Atg8. Here, we describe an Atg7- and Atg3-independent autophagy pathway that facilitates programmed reduction of cell size ...
Chang, Tsun-Kai +6 more
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Discovery of Atg5/Atg7-independent alternative macroautophagy [PDF]
Nature, 2009 Macroautophagy is a process that leads to the bulk degradation of subcellular constituents by producing autophagosomes/autolysosomes. It is believed that Atg5 (ref. 4) and Atg7 (ref. 5) are essential genes for mammalian macroautophagy. Here we show, however, that mouse cells lacking Atg5 or Atg7 can still form autophagosomes/autolysosomes and perform ...
Nishida, Yuya +9 more
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Atg7 Knockdown Reduces Chemerin Secretion in Murine Adipocytes [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2019 Abstract Context In individuals with obesity, adipocyte endocrine function is affected by altered autophagy. Genetic variants in autophagy-related gene 7 (ATG7) correlated with serum chemerin (RARRES2) concentrations.
Sascha Heinitz +12 more
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Oxidative Medicine and Cellular Longevity, 2022 Background. Ferroptosis has gained significant attention from oncologists as a vital outcome of oxidative stress. The aim of this study was to develop a prognostic signature that was based on the ferroptosis‐related genes (FRGs) for osteosarcoma patients and explore their specific role in osteosarcoma. Methods. The training cohort dataset was extracted
Runyi Jiang +12 more
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Renal Failure, 2019 Objective: To identify the significance of autophagy in lupus nephritis (LN). Methods: The number of autophagosomes in podocytes was counted and the expression of multiple molecular markers associated with autophagy was evaluated in LN specimens: in ...
Juan Jin +5 more
doaj +1 more source
Biomolecules, 2019 Many studies have focused on how autophagy plays an important role in intestinal homeostasis under pathological conditions. However, its role in the intestine during hibernation remains unclear.
Waseem Ali Vistro +9 more
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Acta Veterinaria, 2017 Induced prenatal hypothyroidism in rat pups leads to accelerated primordial follicle assembly and premature follicular atresia with ovary failure. This work investigates the influence of maternal hypothyroidism induced with 6-n-propyl-2-thyouracil (PTU ...
Danilović Luković Jelena +6 more
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, 2023 We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of autophagy-related 7 (ATG7) by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
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Essential role of ATG7 in LPS-induced endometrial inflammatory injury in goats
Animal Diseases, 2023 The economic losses caused by uterine infections in ruminants have received increasing attention. Autophagy-related 7 (ATG7) has been demonstrated to be capable of regulating apoptosis, but surprisingly, ATG7 can both promote and inhibit apoptosis in ...
Tingting Jiang +2 more
doaj +1 more source