Results 41 to 50 of about 31,821 (205)

Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]

, 2018
Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong, Gao, Limo, Huang, Bo, Huang, Cao, Shi, Xinglong   +4 more
core   +2 more sources

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy [PDF]

Nature Communications, 2018
AbstractMacroautophagy (autophagy) is a crucial cellular stress response for degrading defective macromolecules and organelles, as well as providing bioenergetic intermediates during hypoxia and nutrient deprivation. Here we report a thiol-dependent process that may account for impaired autophagy during aging.
Frudd, Karen, Burgoyne, Tomas, Burgoyne, Joe   +2 more
openaire   +8 more sources

Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]

, 2012
The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A, Christopher J. Weston, David H. Adams, Munafo´ DB, Ricky H. Bhogal, Schroedl C, Simon C. Afford, Stuart M. Curbishley   +7 more
core   +1 more source

Control of ATG7 by NOD2.

, 2023
We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of autophagy-related 7 (ATG7) by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
openaire   +1 more source

Sevoflurane up-regulates miR-7a to protect against ischemic brain injury in rats by down-regulating ATG7 and reducing neuronal autophagy

Brain Research Bulletin, 2022
The current study aimed to elucidate the effects of Sevoflurane on neuronal autophagy and ischemic brain injury by regulating miR-7a/ATG7 axis. The rat model of middle cerebral artery occlusion (MCAO) was established by thread embolization.
Zhiguo Wu, Jian Tan, Lichang Lin, Wenting Zhang, Wanqiu Yuan   +4 more
doaj   +1 more source

Human cachexia induces changes in mitochondria, autophagy and apoptosis in the skeletal muscle [PDF]

, 2019
Cachexia is a wasting syndrome characterized by the continuous loss of skeletal muscle mass due to imbalance between protein synthesis and degradation, which is related with poor prognosis and compromised quality of life.
Alcantara, P. S., Coletti, D., de Castro, G. S., Festuccia, W. T., Lima, J. D. C. C., Ortiz-Silva, M., Otoch, J. P., Seelaender, M., Simoes, E., Tokeshi, F.   +9 more
core   +1 more source

Trophoblast-Specific Conditional Atg7 Knockout Mice Develop Gestational Hypertension [PDF]

The American Journal of Pathology, 2018
Hypertensive disorder of pregnancy (HDP) is a serious pregnancy complication that is life threatening to both the mother and fetus. Understanding HDP pathophysiology is important for developing medical treatments. This study demonstrates the involvement of autophagy deficiency in adverse maternal and fetal outcomes using trophoblast-specific autophagy ...
Aiko Aoki, Akitoshi Nakashima, Tae Kusabiraki, Yosuke Ono, Osamu Yoshino, Masanaga Muto, Keiichi Kumasawa, Tamotsu Yoshimori, Masahito Ikawa, Shigeru Saito   +9 more
openaire   +2 more sources

A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade

, 2019
Autophagy depends on the E2 enzyme, Atg3, functioning in a conserved E1-E2-E3 trienzyme cascade that catalyzes lipidation of Atg8-family ubiquitin-like proteins (UBLs).
Grace, C., Klionsky, D., Liu, X., Qiu, Y., Schulman, B., Zheng, Y.   +5 more
core   +1 more source

Modulation of plant autophagy during pathogen attack [PDF]

, 2017
In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens,
Bozkurt, Tolga O., Duggan, Cian, Leary, Alexandre Y, Pandey, Pooja, Salguero Linares, Jose, Sanguankiattichai, Nattapong, Savage, Zachary D, Segretin, Maria Eugenia, Tumtas, Yasin, Yow, Rui Jin   +9 more
core   +1 more source

Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo [PDF]

, 2018
Autophagy plays a very important role in numerous physiological and pathological events. However, it still remains unclear whether Atg7-induced autophagy is involved in the regulation of neural crest cell production.
A Kuma, AJ Chalpe, AM Lacosta, Andrea Münsterberg, B Levine, B Ravikumar, BK Hall, C Gao, C Zhuo, Chang Liang, D Henrique, DR Cordero, E Coucouvanis, En-ni Chen, G Juhasz, G Wang, G Wang, Guang Wang, IH Lee, J Cayuso, J Jang, J McCredie, JE Simkin, Jianxin Liang, L Hari, L Lamalice, L Pinsky, Lin-rui Gao, Liu Cao, M Komatsu, MA Mellen, Manli Chuai, ML Basch, MR Aburto, OO Oyedele, PJ Fraker, Q Yue, RA Schneider, RC Russell, S Somi, SC Chapman, SV Hegarty, TC Carter, TF Gale, WH Lu, X Qu, X Wu, X Yang, X Yang, Xuesong Yang, XY Wang, Y Liu, Yongping Bao, Z Jia   +53 more
core   +3 more sources