Results 61 to 70 of about 25,612 (182)

Western blot analysis confirming Atg7 knockdown by siRNA.

, 2023
(A) Western blotting of Atg7 was conducted in THP-1 macrophages with or without knockdown treatment. (B) The ratio of Atg7/GAPDH was calculated. *P (TIF)
Shanshan Li (114847), Yuanyuan Liu (136992), Xiaobo Liu (296632), Yan Cui (9885), Lei Yao (75933), Ruili Chen (9636926), Yu Zhen (198446), Yang Song (88132), Mengqi Guan (9636923)   +8 more
core   +1 more source

Atg7 in CD4+ T cells improves intestinal mucosal inflammation by regulating Ets1‐mediated T cell differentiation

Clinical and Translational Medicine
Background Atg7‐autophagy–related gene 7 contributes as an immune cell function regulator, particularly involved in CD4⁺ T cell response. Nevertheless, the specific contribution of Atg7 in CD4⁺ T cells sensitive immune responses in inflammatory bowel ...
Yue‐Tao Zhou, Quan‐Gui Zhang, Si‐Yuan Du, Hong Chen, Mei‐Zhen Zhu, Min Ai, Shuang‐Shuang Li, Meng‐Nan Dai, Xi‐Ting Wang, Yan Jin, Ying‐Wei Zhu, Jian Lu, Fei Xu, Xue‐Xue Zhu, Li‐Ying Qiu, Hai‐Jian Sun   +15 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Atg7-knockdown reduces chemerin secretion in murine adipocytes

, 2019
Context In obese individuals, adipocyte endocrine function is affected by altered autophagy. Genetic variants in autophagy-related gene 7 (ATG7) correlated with serum chemerin (RARRES2) concentrations.
Rudich, Assaf, Gebhardt, Claudia, Piaggi, Paolo, Krüger, Jacqueline, Blüher, Matthias, Weiner, Juliane, Baier, Leslie, Kovacs, Peter, Tönjes, Anke, Heyne, Henrike, Heiker, John T, Heinitz, Sascha, Stumvoll, Michael   +12 more
core   +1 more source

ATG7-induced autophagy inhibits ferroptosis and promotes the progression of colorectal adenocarcinoma

Discover Oncology
Purpose To investigate the role of ATG7-induced autophagy in regulating ferroptosis and promoting the progression of colorectal adenocarcinoma (COAD). Method The UALCAN database was used to predict the expression of ATG7 and its prognosis significance in
Minyuan Chen, Ziqi Meng, Limei Zhu, Jieyu Liu   +3 more
doaj   +1 more source

ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling

Cell Communication and Signaling, 2019
Background Autophagy and ER stress are involved in maintaining some well-orchestrated mechanisms aimed at either restoring cellular homeostasis or performing cell death.
Wei Zheng, Weiwei Xie, Danyang Yin, Rui Luo, Min Liu, Fengjin Guo   +5 more
doaj   +1 more source

Lipid droplet profiling during neutrophil differentiation by stimulated Raman scattering microscopy

Biotechnology Progress, EarlyView.
Abstract Lipid droplets (LDs) are dynamic organelles that serve as metabolic hubs and emerging regulators of immune cell fate. Although LDs have been implicated in immune regulation, how LD metabolism is remodeled during neutrophil differentiation and how stage‐specific LD dynamics shape mature neutrophil function remain poorly defined.
Ting‐Jung Sung, Bin Dong, Jingqiao Shen, Yan Tan, Chi Zhang, Xiaoping Bao   +5 more
wiley   +1 more source

Discovery of Atg5/Atg7-independent alternative macroautophagy [PDF]

, 2009
Macroautophagy is a process that leads to the bulk degradation of subcellular constituents by producing autophagosomes/autolysosomes(1-3). It is believed that Atg5 (ref. 4) and Atg7 (ref. 5) are essential genes for mammalian macroautophagy. Here we show,
Toku Kanaseki, Fujitani, Kenji, Tsujimoto, Yoshihide, Kenji Fujitani, Masaaki Komatsu, Takeshi Mizuta, Nishida, Yuya, Mizuta, Takeshi, Yuya Nishida, Yoshihide Tsujimoto, Arakawa, Satoko, Kanaseki, Toku, Hirofumi Yamaguchi, Shigeomi Shimizu, Shimizu, Shigeomi, Kinya Otsu, Komatsu, Masaaki, Otsu, Kinya, Satoko Arakawa, Yamaguchi, Hirofumi   +19 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source