Results 161 to 170 of about 22,190 (186)
International Journal of Molecular Sciences, 2023 The autophagy gene ATG7 has been shown to be essential for the induction of autophagy, a process that used to be suppressed in nonalcoholic fatty liver disease (NAFLD). However, the specific role of ATG7 in NAFLD remains unclear. The aim of this study was to analyze hepatic ATG7 mRNA and ATG7 protein expression regarding obesity-associated NAFLD ...
Andrea Barrientos-Riosalido +2 more
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ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 The role of autophagy in cancer is complex. Both tumor-promoting and tumor-suppressive effects are reported, with tumor type, stage and specific genetic lesions dictating the role. This calls for analysis in models that best recapitulate each tumor type, from initiation to metastatic disease, to specifically understand the contribution of ...
Jaclyn S Long +2 more
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Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors
Bioorganic and Medicinal Chemistry, 2020 Autophagy is postulated to be required by cancer cells to survive periods of metabolic and/or hypoxic stress. ATG7 is the E1 enzyme that is required for activation of Ubl conjugation pathways involved in autophagosome formation. This article describes the design and optimization of pyrazolopyrimidine sulfamate compounds as potent and selective ...
James E Brownell, Saurabh Menon
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ATG7 safeguards human neural integrity
Autophagy, 2021ATG7 drives macroautophagy, hereafter "autophagy", by generating ATG12-ATG5 conjugates and lipidating Atg8 homologs including LC3. A pioneering body of work has defined the requirement of ATG7 for survival in mice and shown that neural-specific atg7 deletion causes neurodegeneration, but it has not been ascertained whether human life is compatible with
Jack J. Collier +3 more
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PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression [PDF]
Autophagy, 2016 Although autophagy is most critical for survival of cancer cells, especially in fast-growing tumors, the mechanism remains to be fully characterized. Herein we report that PSMD10/gankyrin promotes autophagy in hepatocellular carcinoma (HCC) in response to starvation or stress through 2 complementary routes. PSMD10 was physically associated with ATG7 in
Wenhao Qin, Juan Li
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Atg7 in development and disease: panacea or Pandora’s Box? [PDF]
Protein and Cell, 2015 Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research.
Jianhua Xiong
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Atg7 is required for acrosome biogenesis during spermatogenesis in mice [PDF]
Cell Research, 2014 The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosome-related organelle (LRO) is still largely unknown.
Haifeng Wan, Weixiao Liu, Yaqing Wang
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Control of autophagosome size and number by Atg7
Biochemical and Biophysical Research Communications, 2018The induction of bulk autophagy by nitrogen starvation in baker's yeast (S. cerevisiae) involves the upregulation of many autophagy related proteins, including Atg7. One way to investigate the importance of this upregulation is to measure the size and number of autophagosomes formed when insufficient amounts of that protein are available. Atg8 is known
Hayley Cawthon +3 more
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Circulation, 2021
Thioredoxin 1 (Trx1) reduces proteins with disulfide bonds. However, when the oxidoreductase activity of Trx1 is inactivated, Trx1 is S-nitrosylated at Cys73 and acts as a trans-nitrosylase. Glucose deprivation (GD) inactivates the oxidoreductase activity of Trx1 and stimulates autophagy in cardiomyocytes. We investigated how Trx1 mediates
Shinichi Oka +4 more
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Thioredoxin 1 (Trx1) reduces proteins with disulfide bonds. However, when the oxidoreductase activity of Trx1 is inactivated, Trx1 is S-nitrosylated at Cys73 and acts as a trans-nitrosylase. Glucose deprivation (GD) inactivates the oxidoreductase activity of Trx1 and stimulates autophagy in cardiomyocytes. We investigated how Trx1 mediates
Shinichi Oka +4 more
openaire +1 more source
PALB2 Synergizes with ATG7 to Suppress Neurodegeneration
Free Radical Biology and Medicine, 2017Autophagy is an intracellular self-digestion process that plays a critical role in maintaining neuronal homeostasis. PALB2 is a tumor suppressor protein essential for homologous recombination-based DNA repair, redox homeostasis and breast cancer suppression.
Yanying Huo +3 more
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