Results 181 to 190 of about 31,821 (205)
Long-term DNA methylation changes induced by age and elevated CO2 in skeletal muscle. [PDF]
Skelet MuscleBalnis J +7 more
europepmc +1 more source
ATG conjugation-dependent/independent mechanisms underlie lysosomal stress-induced TFEB regulation. [PDF]
J Cell BiolAkayama S +9 more
europepmc +1 more source
Discovery of Atg5/Atg7-independent alternative macroautophagy
Discovery of Atg5/Atg7-independent alternative macroautophagyopenaire
Discovery of Atg5/Atg7-independent alternative macroautophagy [PDF]
Nature, 2009 Macroautophagy is a process that leads to the bulk degradation of subcellular constituents by producing autophagosomes/autolysosomes. It is believed that Atg5 (ref. 4) and Atg7 (ref. 5) are essential genes for mammalian macroautophagy. Here we show, however, that mouse cells lacking Atg5 or Atg7 can still form autophagosomes/autolysosomes and perform ...
Yuya Nishida +2 more
exaly +9 more sources
Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans
New England Journal of Medicine, 2021 Autophagy is the major intracellular degradation route in mammalian cells. Systemic ablation of core autophagy-related (ATG) genes in mice leads to embryonic or perinatal lethality, and conditional models show neurodegeneration. Impaired autophagy has been associated with a range of complex human diseases, yet congenital autophagy disorders are rare.We
Monika Oláhová +2 more
exaly +6 more sources
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ATG7 safeguards human neural integrity
Autophagy, 2021ATG7 drives macroautophagy, hereafter "autophagy", by generating ATG12-ATG5 conjugates and lipidating Atg8 homologs including LC3. A pioneering body of work has defined the requirement of ATG7 for survival in mice and shown that neural-specific atg7 deletion causes neurodegeneration, but it has not been ascertained whether human life is compatible with
Jack J. Collier +3 more
openaire +3 more sources
PSMD10/gankyrin induces autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression [PDF]
Autophagy, 2016 Although autophagy is most critical for survival of cancer cells, especially in fast-growing tumors, the mechanism remains to be fully characterized. Herein we report that PSMD10/gankyrin promotes autophagy in hepatocellular carcinoma (HCC) in response to starvation or stress through 2 complementary routes. PSMD10 was physically associated with ATG7 in
Rongyang Dai, Juan Li, Yao Chen
exaly +5 more sources
Circulation, 2021
Thioredoxin 1 (Trx1) reduces proteins with disulfide bonds. However, when the oxidoreductase activity of Trx1 is inactivated, Trx1 is S-nitrosylated at Cys73 and acts as a trans-nitrosylase. Glucose deprivation (GD) inactivates the oxidoreductase activity of Trx1 and stimulates autophagy in cardiomyocytes. We investigated how Trx1 mediates
Shinichi Oka +4 more
openaire +1 more source
Thioredoxin 1 (Trx1) reduces proteins with disulfide bonds. However, when the oxidoreductase activity of Trx1 is inactivated, Trx1 is S-nitrosylated at Cys73 and acts as a trans-nitrosylase. Glucose deprivation (GD) inactivates the oxidoreductase activity of Trx1 and stimulates autophagy in cardiomyocytes. We investigated how Trx1 mediates
Shinichi Oka +4 more
openaire +1 more source
Atg7 is required for acrosome biogenesis during spermatogenesis in mice [PDF]
Cell Research, 2014 The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosome-related organelle (LRO) is still largely unknown.
Haifeng Wan, Qi Chen, Yaqing Wang
exaly +3 more sources