Results 191 to 200 of about 31,821 (205)
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction [PDF]
Autophagy, 2019 TP53INP2/DOR (tumor protein p53-inducible nuclear protein 2) contributes to mammalian macroautophagy/autophagy by carrying nuclear deacetylated MAP1LC3/LC3 to the cytoplasm. Here, we report that in the cytoplasm, TP53INP2 further functions in autophagosome biogenesis by promoting LC3B-ATG7 interaction. Cytoplasmic expression of the N-terminal region of
Zhiyuan You, Wei Wan, Jin Li
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Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7 [PDF]
Molecular Cell, 2011 E1 enzymes activate ubiquitin-like proteins and transfer them to cognate E2 enzymes. Atg7, a noncanonical E1, activates two ubiquitin-like proteins, Atg8 and Atg12, and plays a crucial role in autophagy. Here, we report crystal structures of full-length Atg7 and its C-terminal domain bound to Atg8 and MgATP, as well as a solution structure of Atg8 ...
Nobuo N Noda +2 more
exaly +3 more sources
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Control of autophagosome size and number by Atg7
Biochemical and Biophysical Research Communications, 2018The induction of bulk autophagy by nitrogen starvation in baker's yeast (S. cerevisiae) involves the upregulation of many autophagy related proteins, including Atg7. One way to investigate the importance of this upregulation is to measure the size and number of autophagosomes formed when insufficient amounts of that protein are available. Atg8 is known
Hayley Cawthon +3 more
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MIR137 Regulates Starvation-Induced Autophagy by Targeting ATG7
Journal of Molecular Neuroscience, 2015Autophagy is a cellular catabolic mechanism in response to stress conditions and has been implicated in the progression and chemoresistance of various cancers. Human microR-137 (MIR137) is involved in neuronal maturation and neurogenesis, while little is known about its role in cancer. In this study, we showed that starvation increased the formation of
Yuecheng, Zeng +4 more
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PALB2 Synergizes with ATG7 to Suppress Neurodegeneration
Free Radical Biology and Medicine, 2017Autophagy is an intracellular self-digestion process that plays a critical role in maintaining neuronal homeostasis. PALB2 is a tumor suppressor protein essential for homologous recombination-based DNA repair, redox homeostasis and breast cancer suppression.
Yanying Huo +3 more
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Novel ATG7::RAF1 gene fusion in malignant glomus tumor
Genes, Chromosomes and Cancer, 2023AbstractGlomus tumors are classified as members of the perivascular myoid family of tumors. Nearly half of these show NOTCH‐gene fusions and a smaller subset has BRAF V600E mutations. Here, we report a novel ATG7::RAF1 fusion in malignant glomus tumor occurring in a 40‐year‐old female which has not been reported in the malignant glomus tumor before.
Saba Shafi +3 more
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Altered glycogen metabolism causes hepatomegaly following an Atg7 deletion
Cell and Tissue Research, 2016Autophagy is a lysosomal degradation process involved in the turnover of organelles or other cell constituents, in providing sources for energy production under starving conditions and in cell metabolism. A key protein in the macroautophagic machinery is the autophagy-related protein (Atg) 7. Constitutive deletion of Atg7 is lethal at birth.
Lara Kern +7 more
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Atg7 in AML: a double-edged sword?
Blood, 2016In this issue of Blood, Piya et al have identified the autophagy-related E1 ligase Atg7, a critical autophagy component associated with unfavorable outcomes in acute myeloid leukemia (AML), as a potential target in this disease.1 If validated, this study could provide a foundation for disrupting Atg7 in AML therapy.
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