Results 21 to 30 of about 994,628 (384)

Atherosclerosis [PDF]

Annals of the Rheumatic Diseases, 2002
Is atherosclerosis a cellular or humoral mediated autoimmune disease?
Y, Sherer, Y, Shoenfeld
openaire   +2 more sources

Connexins in atherosclerosis

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Atherosclerosis, a chronic inflammatory disease of the vessel wall, involves multiple cell types of different origins, and complex interactions and signaling pathways between them. Autocrine and paracrine communication pathways provided by cytokines, chemokines, growth factors and lipid mediators are central to atherogenesis.
Pfenniger, Anna, Chanson, Marc, Kwak, Brenda   +2 more
openaire   +4 more sources

Body temperature and mouse scoring systems as surrogate markers of death in cecal ligation and puncture sepsis

Intensive Care Medicine Experimental, 2018
Background Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score for Sepsis (M-CASS), and Mouse ...
Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud, Patricia C. Liaw   +7 more
doaj   +1 more source

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Nature reviews. Drug discovery, 2021
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves inflammation from its inception to the emergence of complications.
O. Soehnlein, P. Libby
semanticscholar   +1 more source

Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice [PDF]

, 2013
Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients.
Egido, J., Gomez-Guerrero, C., Lazaro, I., Lopez-Franco, O., Lopez-Parra, V., Lutgens, E., Mallavia, B., Oguiza, A., Ortiz-Muñoz, G., Recio, C.   +9 more
core   +10 more sources

D4F alleviates macrophage-derived foam cell apoptosis by inhibiting the NF-κB-dependent Fas/FasL pathway

Scientific Reports, 2017
This study was designed to explore the protective effect of D4F, an apolipoprotein A-I mimetic peptide, on nuclear factor-κB (NF-κB)-dependent Fas/Fas ligand (FasL) pathway-mediated apoptosis in macrophages induced by oxidized low-density lipoprotein (ox-
Hua Tian, Shu-tong Yao, Na-na Yang, Jie Ren, Peng Jiao, Xiangjian Zhang, Dong-xuan Li, Gong-an Zhang, Zhen-fang Xia, Shu-cun Qin   +9 more
doaj   +1 more source

In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption

Journal of Lipid Research, 2013
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester and triglyceride between HDL and apoB-containing lipoproteins. Anacetrapib (ANA), a reversible inhibitor of CETP, raises HDL cholesterol and lowers LDL cholesterol in dyslipidemic ...
Sheng-Ping Wang, Erin Daniels, Ying Chen, Jose Castro-Perez, Haihong Zhou, Karen O. Akinsanya, Stephen F. Previs, Thomas P. Roddy, Douglas G. Johns   +8 more
doaj   +1 more source

Macrophage autophagy in atherosclerosis [PDF]

, 2013
Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Carnuccio, R., Grassia, G., Ialenti, A., Maffia, P., Maiuri, M.C., Platt, A.   +5 more
core   +2 more sources

Niacin Inhibits Vascular Inflammation via Downregulating Nuclear Transcription Factor-κB Signaling Pathway

Mediators of Inflammation, 2014
The study aimed to investigate the effect of niacin on vascular inflammatory lesions in vivo and in vitro as well as its lipid-regulating mechanism. In vivo study revealed that niacin downregulated the levels of inflammatory factors (IL-6 and TNF-α) in ...
Yanhong Si, Ying Zhang, Jilong Zhao, Shoudong Guo, Lei Zhai, Shutong Yao, Hui Sang, Nana Yang, Guohua Song, Jue Gu, Shucun Qin   +10 more
doaj   +1 more source

Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E.

Journal of Lipid Research, 1995
Apolipoprotein E (apoE), a 299 amino acid protein, is a ligand for the low density lipoprotein receptor (LDLr). It has been established that basic amino acids situated between apoE residues 136 and 150 participate in the interaction of apoE with the LDLr.
R Raffai, R Maurice, K Weisgraber, T Innerarity, X Wang, R MacKenzie, T Hirama, D Watson, E Rassart, R Milne   +9 more
doaj   +1 more source