Results 31 to 40 of about 706,977 (192)

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice [PDF]

, 2010
Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease ...
Benson, G. Martin, C. Connor, Susan, C. Grimsditch, David, G. Reid, David, Kian Kai, Cheng, L. Griffin, Julian   +5 more
core   +1 more source

Dataset on inflammatory proteins expressions and sialic acid levels in apolipoprotein E-deficient mice with administration of N-acetylneuraminic acid and/or quercetin

Data in Brief, 2016
The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-α, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice
Rongrong Dong, Fahui Li, Shucun Qin, Yi Wang, Yanhong Si, Xuelian Xu, Hua Tian, Lei Zhai, Guangjie Zhang, Yongjun Li, Yawei Zhou, Ying Zhang, Nan Zhang, Shoudong Guo   +13 more
doaj   +1 more source

Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor-Deficient Mice [PDF]

, 2008
Objective—Atherosclerosis is a vascular disease that involves lesion formation at sites of disturbed flow under the influence of genetic and environmental factors.
Arora, Shikha, Boylan, Brian, Fleming, Barbara, Fleming, Rose Ann, Goel, Reema, Mirura, Hiroto, Molthen, Robert C., Newman, Debra K., Newman, Peter J., Schrank, Benjamin R.   +9 more
core   +2 more sources

Adipose tissue cholesteryl ester transfer protein mRNA in response to probucol treatment: cholesterol and species dependence

Journal of Lipid Research, 1993
Probucol treatment results in an increase in plasma concentrations of cholesteryl ester transfer protein (CETP) which may account, in part, for the effects of this agent on plasma concentrations of HDL cholesterol. We have examined the mechanism by which
EM Quinet, P Huerta, D Nancoo, AR Tall, YL Marcel, R McPherson   +5 more
doaj   +1 more source

Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water

Journal of Lipid Research, 2012
Stable isotope tracer studies of apoprotein flux in rodent models present difficulties as they require working with small volumes of plasma. We demonstrate the ability to measure apoprotein flux by administering either 2H- or 18O-labeled water to mice ...
Haihong Zhou, Wenyu Li, Sheng-Ping Wang, Vivienne Mendoza, Raymond Rosa, James Hubert, Kithsiri Herath, Theresa McLaughlin, Rory J. Rohm, Michael E. Lassman, Kenny K. Wong, Douglas G. Johns, Stephen F. Previs, Brian K. Hubbard, Thomas P. Roddy   +14 more
doaj   +1 more source

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease [PDF]

, 2017
Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system.
Matsakas, Antonios, Sfyri, Peggy
core   +1 more source

The metabolic syndrome adds utility to the prediction of mortality over its components: The Vietnam Experience Study [PDF]

, 2009
Background\ud The metabolic syndrome increases mortality risk. However, as “non-affected” individuals may still have up to two risk factors, the utility of using three or more components to identify the syndrome, and its predictive advantage over ...
Anna C. Phillips, Ardern, Batty, Batty, Catharine R. Gale, Douglas Carroll, Eberly, Ford, Ford, G. David Batty, G. Neil Thomas, Ho, Hu, Hunt, Isomaa, Kannel, Katzmarzyk, Lakka, Malik, Onat, Sattar, Simons, Smith, Sundstrom, Sundström   +24 more
core   +1 more source

Cholesteryl ester transfer protein (CETP) mRNA abundance in human adipose tissue: relationship to cell size and membrane cholesterol content.

Journal of Lipid Research, 1995
Cholesteryl ester transfer protein (CETP) has a well-defined role in plasma neutral lipid transport. CETP synthesized by human adipose tissue may contribute to the plasma CETP pool. CETP mRNA abundance increases in subcutaneous adipose tissue in response
T Radeau, P Lau, M Robb, M McDonnell, G Ailhaud, R McPherson   +5 more
doaj   +1 more source

Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice [PDF]

, 2013
OBJECTIVE OF THE STUDY: Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated
Andersson, AM, Bengtsson, E, Berglund, LM, Blanco, F, Dunér, P, Garcia-Vaz, E, Gomez, MF, Nilsson, J, Spegel, P, To, F, Wigren, M, Zetterqvist, AV   +11 more
core   +1 more source

Isolation and characterization of an apoA-II-containing lipoprotein (LP-A-II:B complex) from plasma very low density lipoproteins of patients with Tangier disease and type V hyperlipoproteinemia.

Journal of Lipid Research, 1991
Previous studies have shown that very low density lipoproteins (VLDL) from patients with Tangier disease are less effective as a substrate for human milk lipoprotein lipase (LPL) than VLDL from normal controls as assessed by measuring the first order ...
P Alaupovic, C Knight-Gibson, CS Wang, D Downs, E Koren, HB Brewer, Jr, RE Gregg   +6 more
doaj   +1 more source