Results 41 to 50 of about 793,722 (339)
Is there a role for thoracic aortic calcium to fine-tune cardiovascular risk prediction? [PDF]
, 2012 Screening asymptomatic subjects to streamline measures for the prevention of cardiovascular events remains a major challenge. The established primary prevention risk-scoring methods use equations derived from large prospective cohort studies, but further
Birgelen, C. von, Hartmann, M.
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
F1000Research, 2017 The direct oral anticoagulants (DOACs) have now supplanted vitamin K antagonists (VKAs) for the treatment of venous thromboembolism (VTE). The DOACs include dabigatran, which inhibits thrombin, and rivaroxaban, apixaban, and edoxaban, which inhibit ...
Jeffrey I. Weitz +2 more
doaj +1 more source
Animals, 2021 Pet ownership positively influences clinical outcomes in cardiovascular prevention. Additionally, cardiovascular disease (CVD) has been previously linked to microbiota dysbiosis.
Javier Arenas-Montes +10 more
doaj +1 more source
Carotid intima media thickness and low high-density lipoprotein (HDL) in South Asian immigrants: could dysfunctional HDL be the missing link? [PDF]
, 2014 IntroductionSouth Asian immigrants (SAIs) in the US exhibit higher prevalence of coronary artery disease (CAD) and its risk factors compared with other ethnic populations.
Dodani, Sunita +3 more
core +2 more sources
Inflammation and Atherosclerosis [PDF]
European Journal of Vascular and Endovascular Surgery, 2006 The aim of this article is to discuss the role of inflammation in atherosclerosis.An initial chemical, mechanical or immunological insult induces endothelial dysfunction. This triggers a cascade of inflammatory reactions, in which monocytes, macrophages, T lymphocytes and vascular smooth muscle cells participate. Leukocyte adhesion molecules, cytokines,
Kaperonis, EA +4 more
openaire +3 more sources
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Scientific Reports, 2021 Endothelial dysfunction is a key player in both the onset and development of atherosclerosis. No study has examined whether healthy dietary patterns can improve microvascular endothelial function in patients with coronary heart disease (CHD) in the long ...
Marta Millan-Orge +11 more
doaj +1 more source
C-peptide: a predictor of cardiovascular mortality in subjects with established atherosclerotic disease [PDF]
, 2017 Aim: Insulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases. Levels of C-peptide are increased in these patients and its role in the atherosclerosis progression was studied in vitro and in vivo over the past ...
Ballanti, Marta +13 more
core +1 more source
Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management. [PDF]
, 2020 Physical activity and exercise training are effective strategies for reducing the risk of cardiovascular events, but multiple studies have reported an increased prevalence of coronary atherosclerosis, usually measured as coronary artery calcification ...
Aengevaeren, VL +7 more
core +3 more sources