Results 31 to 40 of about 634,659 (335)
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]
, 2020 The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina +10 more
core +3 more sources
The Relationship Between Satisfaction, Trust and Loyalty in Electronic Banking
Финансы: теория и практика, 2022 Nowadays, the increase of competition has made organizations constantly strive to increase their productivity and reduce their costs. The rapid growth of systems based on electronic technology led to a significant change in banking services.
I. Zyberi, D. Luzo (Kllapi)
doaj +1 more source
ATM in focus:a damage sensor and cancer target [PDF]
, 2012 The ability of a cell to conserve and maintain its native DNA sequence is fundamental for the survival and normal functioning of the whole organism and protection from cancer development.
Khalil, Hilal S. +2 more
core +4 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Multimodal Transportation, 2022 Frankfurt Airport is a role model for intermodal infrastructure, given its excellent degree of air, rail, and road connectivity. The connection Cologne-Frankfurt, for instance, is frequently used as the prime example for air-rail mode substitution, where
Sebastian Wandelt, Xiaoqian Sun
doaj +1 more source
Oncotarget, 2015 Senescence is a state of stable cell growth arrest that can be triggered by multiple stressors, including oncogene activation [1]. In normal diploid mammalian cells, activation of oncogenes such as oncogenic RAS or BRAF decreases dNTP levels, which leads to replication stress and ultimately senescence [2].
Katherine M, Aird, Rugang, Zhang
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Cell-level path allocation in a three-stage ATM switch [PDF]
, 1994 A method of cell-level path allocation for three-stage ATM switches has previously been proposed by the authors. The performance of ATM switches using this path allocation algorithm has been evaluated by simulation, and is described. Both uniform and non-
Collier, Martin, Curran, Thomas
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Survey of traffic control schemes and error control schemes for ATM networks [PDF]
, 1991 Among the techniques proposed for B-ISDN transfer mode, ATM concept is considered to be the most promising transfer technique because of its flexibility and efficiency. This paper surveys and reviews a number of topics related to ATM networks.
Bae, Jaime Jungok, Suda, Tatsuya
core