Results 61 to 70 of about 13,871 (266)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Two-dimensional Models of Microphysical Clouds on Hot Jupiters. I. Cloud Properties

The Astrophysical Journal
We present a new two-dimensional, bin-scheme microphysical model of cloud formation in the atmospheres of hot Jupiters that includes the effects of longitudinal gas and cloud transport.
Diana Powell, Xi Zhang
doaj   +1 more source

Atmospheric Water Harvesting Through Polymer Hydrogel Sorbents: Materials Chemistry, Design Strategies, and Applications

Advanced Science, EarlyView.
Polymer‐based hydrogels have emerged as promising materials for atmospheric water harvesting (AWH) due to their high water affinity, tunable network structure, and excellent moisture adsorption‐desorption performance. Functional hydrogel systems enable efficient water capture and controlled release under low‐energy conditions, offering a sustainable ...
Swagata Datta, Sushmit Sen, Nilanjan Dey, Amrita Chatterjee, Ananya Sadhu, Sudipta Sarkar, Pradip K. Maji   +6 more
wiley   +1 more source

One-dimensional Microphysics Model of Venusian Clouds from 40 to 100 km: Impact of the Middle-atmosphere Eddy Transport and SOIR Temperature Profile on the Cloud Structure

The Planetary Science Journal
We conducted a simulation of H _2 SO _4 vapor, H _2 O vapor, and H _2 SO _4 –H _2 O liquid aerosols from 40 to 100 km, using a 1D Venus cloud microphysics model based on the one detailed in Imamura & Hashimoto.
Hiroki Karyu, Takeshi Kuroda, Takeshi Imamura, Naoki Terada, Ann Carine Vandaele, Arnaud Mahieux, Sébastien Viscardy   +6 more
doaj   +1 more source

Special Issue Atmospheric Composition and Cloud Cover Observations

Atmosphere, 2020
A Special Issue of Atmosphere, “Atmospheric Composition and Cloud Cover Observations”, is focused on presenting some of the latest results of observations of clouds and atmospheric composition, mainly by referring to new equipment or experimental set-ups
Mirela Voiculescu
doaj   +1 more source

Low Latency Global Carbon Budget Reveals Late 2024 Carbon Losses and Contrasting Early 2025 Land Sink Recovery Signals

Advanced Science, EarlyView.
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke, Philippe Ciais, Yitong Yao, Stephen Sitch, Wei Li, Xiaomeng Du, Xiaofan Gui, Ben Poulter, Thomas Colligan, Auke M. van der Woude, Joram Hooghiem, Wouter Peters, Zhu Liu, Zhu Deng, Zhe Jin, Xiangjun Tian, Yilong Wang, Junjie Liu, Sudhanshu Pandey, Chris O'Dell, Jiang Bian, John Miller, Xin Lan, Jefferson Goncalves De Souza, Michael O'Sullivan, Pierre Friedlingstein, Julien Alléon, Yi Xi, Daniel S. Goll, Lei Zhu, Guido R. van der Werf, Shilong Piao, Frédéric Chevallier   +32 more
wiley   +1 more source

Analysis of the Micro-Physical Characteristics of the Sea of Clouds Phenomena in Jiuxian Mountain Based on Multiple Source Observations

Atmosphere
The micro-physical characteristics of a typical sea of clouds process in Jiuxian Mountain are investigated by comprehensively analyzing parameters that delineate the micro-physical characteristics of clouds and atmospheric stratification based on data ...
Si Cheng, Zilun Lin, Jianding Zhou, Geng Han, Zhenhao Chen, Qingbo Yang   +5 more
doaj   +1 more source

Bridging Horizontal to Vertical Radiative Cooling

Advanced Science, EarlyView.
Radiative cooling materials are mature but only work facing the sky, confining them to rooftops. Instead of developing new ones, this system bridges existing horizontal coolers to vertical windows using blades outside the glass. On an occupied urban building, windows stay up to 1.4°C below air temperature while preserving daylight, outward views, and ...
Xiangyu Meng, Gan Huang
wiley   +1 more source

A One-dimensional Microphysical Model of the Venus Cloud System between 40 and 80 km Including Photochemistry and Radiative-dynamic Feedback

The Planetary Science Journal
We present results from 1D simulations using PlanetCARMA for Venus in which, for the first time, a sophisticated 1D cloud microphysics model has simultaneously incorporated simplified diurnally varying photochemistry, parameterized diurnally varying ...
Kevin McGouldrick, Erika L. Barth
doaj   +1 more source