Results 91 to 100 of about 15,535 (284)

Disruption of the SNRPF–DDX24–E2F4 Feedback Loop Uncouples Splicing and Transcriptional Regulation to Suppress Ovarian Cancer Progression

Advanced Science, EarlyView.
This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li, Zhongshao Chen, Qianqian Gao, Yuehan Gao, Ning Yang   +4 more
wiley   +1 more source

Magnetospheric processes mediate atmospheric escape at Earth, Mars, and Venus: key open questions demand renewed Venus exploration

, 2023
International audienceEarth, Mars, and Venus span a range of magnetosphere configurations, from the global/intrinsic dipole field of Earth, through the hybrid crustal field and induced magnetosphere of Mars, to the wholly induced magnetosphere of Venus ...
Hanley, Kathleen Gwen, Stone, Shane Wesley, Barjatya, Aroh, Benna, Mehdi, Whittlesey, Phyllis, Larson, Davin E, Ramstad, Robin, Xu, Shaosui, Fowler, Christopher M, Luhmann, Janet G, Curry, Shannon, Chaffin, Michael, Lillis, Robert J, Livi, Roberto, Collinson, Glyn, Quémerais, Eric, Chaufray, Jean-Yves, Parker, Jeffrey   +17 more
core   +1 more source

Atmospheric Escape in Exoplanets: a Journey From Gas Giants to Earth Twins

, 2021
Most planets are surrounded by a layer of material in gas phase with varying levels of physical and chemical properties. The planetary upper atmosphere invariably extend to space with decreasing levels of density and increasing gas particle velocities ...
Dos Santos, Leonardo
core   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Insights Into CO2 Loss, pH Effects, and Tafel Kinetics in Ni Single Atom‐Driven Bicarbonate Electroreduction

Advanced Science, EarlyView.
Selective CO formation in bicarbonate electrolysis is achieved by retaining reactive CO2 and tuning pH, while the competing hydrogen evolution reaction occurs at the interface. The rate‐determining step couples the chemical equilibrium of bicarbonate/CO2 with electrochemical charge transfer, offering insight into optimizing reaction conditions for ...
Lin Li, Yi‐Jie Kong, Ting Zhang, Xu Han, Kristine Aalestrup, Steen Uttrup Pedersen, Xin‐Ming Hu, Kim Daasbjerg   +7 more
wiley   +1 more source

Escape of Gases from Atmospheres

The Astrophysical Journal, 1900
IN the Literary Supplement of the Times of December 25, 1903, an erroneous statement is on p. 375 placed before its readers, to the effect that our alleged knowledge of the escape of some gases from the atmospheres of planets and satellites is based on an assumed absence of helium from the earth's atmosphere, and has been disposed of by the discovery ...
openaire   +1 more source

Atmospheric escape from the Earth during geomagnetic reversal

, 2020
We considered basic mechanisms of atmospheric particle acceleration and estimated the escape rates of ionospheric ions (H+ and O+) during the geomagnetic field reversal.
Dubinin, E., Malova, H., Malova, Helmi V., Popov, Victor Yu., Tsareva, Olga O., Popov, V., Dubinin, Eduard M., Tsareva, O., Zelenyi, L., Zelenyi, Lev M.   +9 more
core   +1 more source

Defect‐Functionalization‐Mediated Tunneling Drives Nonlinear Photoemission in Perovskites

Advanced Science, EarlyView.
This cover illustration depicts CsPbBr3 perovskite nanocrystals embedded with functionalized defect vacancies, where electrons migrate through defect‐mediated pathways and emit as lightning‐like beams. The imagery visualizes the core discovery of our work—defect‐functionalization‐mediated tunneling enabling nonlinear photoemission, where deep‐level ...
Hang Ren, Xi Zhang, Yicheng Wang, Shuai Wang, Zhi Wang, Yumeng Li, Jikai Yang, Xin Wang, Weijun Chen, Yining Mu   +9 more
wiley   +1 more source

Upstream IMF Influence on Closed Magnetic Field Orientation on Mars

Geophysical Research Letters
Closed magnetic fields play an important role in plasma transport and atmospheric escape from the Martian dayside ionosphere. Leveraging in‐situ magnetic field data from the Mars Atmosphere and Volatile EvolutioN (MAVEN) mission, we conduct a statistical
JunFeng Qin, Shannon Curry, Shaosui Xu, Dave Mitchell, Rob Lillis, Chi Zhang   +5 more
doaj   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source