Results 31 to 40 of about 81,014 (268)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Understanding ozone variability in spatial responses to emissions and meteorology in China using interpretable machine learning

iScience
Summary: To effectively control regional ozone pollution, it is crucial to investigate ozone variability in spatial responses to emissions and meteorology.
Xin Zhang, Wei-Chun Zhang, Wei Wu, Hong-Bin Liu   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Water Vapor Characteristics of Extreme Precipitation in Yingjiang, the “Rain Pole” of Mainland China

Applied Sciences
In the Yingjiang area of western Yunnan, precipitation is high throughout the year, making it one of the regions with the highest annual precipitation in mainland China.
Jin Luo, Liyan Xie, Weimin Wang, Yunchang Cao, Hong Liang, Yizhu Wang, Balin Xu   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Development of Side Bidirectional Leader and Its Effect on Channel Branching of the Progressing Positive Leader of Lightning

Geophysical Research Letters, 2019
Fine time‐resolved images of the development of lightning bidirectional leaders below the cloud base were captured by a high‐speed camera in association with multiband electromagnetic field measurements.
Shanfeng Yuan, Rubin Jiang, Xiushu Qie, Zhuling Sun, Dongfang Wang, Abhay Srivastava   +5 more
doaj   +1 more source

Observable medium effects for atmospheric neutrinos [PDF]

Proceedings of International Europhysics Conference on High Energy Physics — PoS(hep2001), 2001
We discuss the possibility to observe matter effects in atmospheric neutrino oscillations. The main conclusion is that an impact on the nu_mu survival probability requires the action of the MSW resonance, which becomes visible for baselines above ~7000 km. The associated muon charge asymmetry carries information on theta_{13} and the sign of Dm^2_{31}.
Bernabeu, J., Palomares-Ruiz, S.
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Can terrestrial laser scanners (TLSs) and hemispherical photographs predict tropical dry forest succession with liana abundance? [PDF]

Biogeosciences, 2017
Tropical dry forests (TDFs) are ecosystems with long drought periods, a mean temperature of 25 °C, a mean annual precipitation that ranges from 900 to 2000 mm, and that possess a high abundance of deciduous species (trees and lianas). What remains of the
G. A. Sánchez-Azofeifa, J. A. Guzmán-Quesada, M. Vega-Araya, C. Campos-Vargas, S. M. Durán, N. D'Souza, T. Gianoli, C. Portillo-Quintero, I. Sharp   +8 more
doaj   +1 more source

Evaluation of the CRTM Land Emissivity Model over Grass and Sand Surfaces Using Ground-Based Measurements

Remote Sensing, 2023
Microwave surface emissivity is complex and variable, leading to increased difficulty in accurately retrieving atmospheric parameters and assimilating satellite microwave observations over land.
Yidan Wang, Wenying He, Minzheng Duan, Hailei Liu, Hongbin Chen, Congzhen Han, Weidong Nan   +6 more
doaj   +1 more source