Results 41 to 50 of about 81,014 (268)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Spatiotemporal analysis of atmospheric aerosols in African environments using MERRA-2 data (1980–2024): Impacts on climate extremes

iScience
Summary: This study investigates atmospheric aerosol trends and their climatic impacts across Africa from 1980 to 2024 using MERRA-2 reanalysis data.
Daniel O. Omokpariola
doaj   +1 more source

Channel branching and zigzagging in negative cloud-to-ground lightning

Scientific Reports, 2017
A fundamental question in lightning flash concerns why the discharge channel propagates in a zig-zag manner and produces extensive branches. Here we report the optical observation of two negative cloud-to-ground lightning discharges with very high ...
Rubin Jiang, Xiushu Qie, Hongbo Zhang, Mingyuan Liu, Zhuling Sun, Gaopeng Lu, Zhichao Wang, Yu Wang   +7 more
doaj   +1 more source

Comparison of the Performance of Different Lightning Jump Algorithms in Beijing

应用气象学报, 2021
Based on S-band Doppler weather radar raw data, the total lightning location data of Beijing Lightning Network (BLNET) and hailfall reports from Beijing Meteorological Service, two lightning jump algorithms, Gatlin algorithm and σ algorithm, with ...
Tian Ye, Yao Wen, Yin Jiali, Qie Xiushu, Cao Haiwei, Li Jin, Yuan Shanfeng, Wang Dongfang   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Cloud Properties under Different Synoptic Circulations: Comparison of Radiosonde and Ground-Based Active Remote Sensing Measurements

Atmosphere, 2016
In this study, long-term (10 years) radiosonde-based cloud data are compared with the ground-based active remote sensing product under six prevailing large-scale synoptic patterns, i.e., cyclonic center (CC), weak pressure pattern (WP), the southeast ...
Jinqiang Zhang, Jun Li, Xiangao Xia, Hongbin Chen, Chao Ling   +4 more
doaj   +1 more source

Observations of atmospheric radiation [PDF]

, 1941
Atmospheric radiation is the primary variable in nocturnal cooling, although wind has greater influence on the temperature of surface air. Since temperature inversions near the ground cannot be formed unless surfaces are cooled by radiation loss to the sky, a knowledge of atmospheric radiation is essential to the proper understanding of radiation ...
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source