Results 51 to 60 of about 39,820 (298)
Aging, 2017 The complexity of the living cell is supported by the multitasking activity of its protein constituents. The kinase Ataxia Telangiectasia Mutated ATM)is a clear example. Not only does it orchestrate the DNA damage response but also sustains cellular homeostasis, including metabolism, control of oxidative stress, autophagy and apoptosis [1]. [...]
Angulo Ibáñez, María +2 more
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Designing on metamodels of air traffic management architecture modeling based on multi-frame modeling language [PDF]
Journal of Intelligent Manufacturing and Special EquipmentPurpose – This paper aims to propose a set of metamodels applicable to the architecture modeling of air traffic management systems|air traffic management system (ATMS) under the UAF methodology.
Liu Tianning +4 more
doaj +1 more source
Adipose tissue macrophages in remote modulation of hepatic glucose production
Frontiers in Immunology, 2022 Hepatic glucose production (HGP) is fine-regulated via glycogenolysis or gluconeogenesis to maintain physiological concentration of blood glucose during fasting-feeding cycle. Aberrant HGP leads to hyperglycemia in obesity-associated diabetes.
Yan Tao, Quanhong Jiang, Qun Wang
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Medical Laboratory Journal, 2015 Background and Objective: Automated Teller Machine (ATMs) is likely to be contaminated with various microorganisms specially pathogen germs. This may be due to their exposure to dust and their vast dermal contact with multiple users.
Moshtaghi, H, Parsa, M
doaj
Pop-up infrastructure: Water ATMs and new delivery networks in India
Water Alternatives, 2020 Over the last decade, thousands of water ATMs have been installed across the Global South. In India, these vending machines increasingly augment both formal and informal networks of water supply and delivery. This article examines media reports on water
Jeremy J. Schmidt
doaj
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
MicroRNA-10a-5p regulates macrophage polarization and promotes therapeutic adipose tissue remodeling
Molecular Metabolism, 2019 Objective: This study investigated the role of microRNAs generated from adipose tissue macrophages (ATMs) during adipose tissue remodeling induced by pharmacological and nutritional stimuli. Methods: Macrophage-specific Dicer knockout (KO) mice were used
Yoon Keun Cho +10 more
doaj +1 more source
Cell Death and Disease, 2021 Activation of adipose tissue macrophages (ATMs) contributes to chronic inflammation and insulin resistance in obesity. However, the transcriptional regulatory machinery involved in ATM activation during the development of obesity is not fully understood.
Ren-Dong Hu +13 more
doaj +1 more source