Results 61 to 70 of about 39,820 (298)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Effect of Accelerated Transcranial Magnetic Stimulation on Insomnia Severity and Sleep Quality in Patients With Treatment-Resistant Depression [PDF]

open access: yesSleep Medicine Research
Background and Objective Insomnia severity and poor sleep quality are linked with a poor response to depression treatments. Furthermore, they may heighten suicide risk, necessitating careful management and treatment of insomnia.
Hilal Uygur   +2 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Evaluation of Electrochemical Impedance Properties of Anticorrosion Films by Arc Thermal Metal Spraying Method

open access: yesInternational Journal of Electrochemical Science, 2015
Arc thermal metal spraying method () provides proven long term protective coating systems using zinc, aluminum and their alloys for steel structure in a marine environment. This paper focused on studying the effect of spraying metal type, and presence or
Hong-Bok Choe   +3 more
doaj   +1 more source

Impacts of Assimilating ATMS Radiances on Heavy Rainfall Forecast in RMAPS-ST

open access: yesRemote Sensing, 2020
The Advanced Technology Microwave Sounder (ATMS) mounted on the Suomi National Polar-Orbiting Partnership (NPP) satellite can provide both temperature and humidity information for a weather prediction model.
Yanhui Xie   +5 more
doaj   +1 more source

Chip and Skim: cloning EMV cards with the pre-play attack [PDF]

open access: yes, 2012
EMV, also known as "Chip and PIN", is the leading system for card payments worldwide. It is used throughout Europe and much of Asia, and is starting to be introduced in North America too. Payment cards contain a chip so they can execute an authentication
Anderson, Ross   +4 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Adipose tissue macrophages in non-rodent mammals: a comparative study [PDF]

open access: yes, 2015
The stromal vascular fraction (SVF) of adipose tissue in rodents and primates contains mesenchymal stem cells and immune cells. SVF cells have complex metabolic, immune and endocrine functions with biomedical impact. However, in other mammals, the amount
Ampem, Grace   +6 more
core   +1 more source

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