Results 81 to 90 of about 39,820 (298)
Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription
Experimental Biology and Medicine, 2012 Ataxia-telangiectasia mutated (ATM) kinase is a component of a signalling mechanism that determines the process of decision-making in response to DNA damage and involves the participation of multiple proteins. ATM is activated by DNA double-strand breaks (DSBs) through the Mre11–Rad50–Nbs1 (MRN) DNA repair complex, and orchestrates signalling cascades ...
Khalil, Hilal S. +3 more
openaire +3 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Single-atom catalysts supported on atomically thin materials for water splitting
Advanced Powder MaterialsSingle-atom catalysts (SACs) have demonstrated exceptional performance in electrocatalytic water splitting, owing to their maximized atomic utilization efficiency and superior reaction kinetics. The incorporation of SACs typically depends on robust metal-
Xiaomin Chen +8 more
doaj +1 more source
Remote Sensing, 2020 The Advanced Microwave Sounding Unit (AMSU)-A/Advanced Technology Microwave Sounder (ATMS) onboard the National Oceanic Atmospheric Administration (NOAA)-18/-19, MetOp-A/-B, and Suomi National Polar-orbiting Partnership satellites provide global ...
Lin Lin, Xiaolei Zou
doaj +1 more source
The Campus Debit Card Trap: Are Bank Partnerships Fair to Students? [PDF]
, 2012 Examines partnerships between colleges and financial firms on campus ID, prepaid, debit, and financial aid disbursement cards and questions about fees, aggressive marketing strategies, and consumer protection.
Donna Cooper, Kristina Costa
core
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Investment and Usage of New Technologies: Evidence from a Shared ATM Network [PDF]
When new technologies become available, it is not only essential that firms have the correct investment incentives, but often also that consumers make the proper usage decisions. This paper studies investment and usage in a shared ATM network.
Degryse, H.A. +2 more
core +1 more source
miR-34a-/- mice are susceptible to diet-induced obesity [PDF]
, 2016 Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H. +7 more
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
MATEC Web of Conferences, 2018 The introduction of automatic teller machines (henceforth ATMs) brought dramatic changes in the way people do banking. ATMs have become a daily necessity and they are widely used for their convenience and accessibility.
Elias Jeremy C., Estember Rene D.
doaj +1 more source