Results 1 to 10 of about 282 (123)

Non-volatile N-nitrosamines in brewing industry. Part II. - Study of the Effect of UV Irradiation on the ATNC and Some Representatives of N-nitrosoaminoacids in Beer. [PDF]

Kvasný Průmysl, 2012
Contrary to volatile N-nitrosamines, about mechanism of decomposion of apparent total N-nitroso compounds and non-volatile nitrosamines e.g. N-nitrosoaminoacids in beer is known only a little.
Tomáš Horak, Pavel Cejka, Jiří Culik   +2 more
exaly   +6 more sources

ATNC: Versatile Nanobody Chimeras for Autophagic Degradation of Intracellular Unligandable and Undruggable Proteins [PDF]

Journal of the American Chemical Society, 2023
Targeted protein degradation (TPD) through the autophagy pathway displays broad substrate scope and is gaining increasing interest in biology and medicine. However, current approaches using small-molecule degraders have limitations due to the lack of versatility, modularity, and ease of implementation and are restricted to addressing only ligandable ...
Huiping He, Chengjian Zhou, Xi Chen
europepmc   +7 more sources

Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers [PDF]

Environmental Health, 2019
Background Nitrate is converted to nitrite in the human body and subsequently can react with amines and amides in the gastrointestinal tract to form N-nitroso compounds (NOCs), which are known to be carcinogenic in animals.
Simone G. van Breda, Karen Mathijs, Virág Sági-Kiss, Gunter G. Kuhnle, Ben van der Veer, Rena R. Jones, Rashmi Sinha, Mary H. Ward, Theo M. de Kok   +8 more
doaj   +5 more sources

INFLUENCE OF NITRATE AND BACTERIAL CONTAMINATION ON THE FORMATION OF APPARENT TOTAL N-NITROSO COMPOUNDS (ATNC) DURING FERMENTATION [PDF]

Journal of the Institute of Brewing, 1989
Formation of Apparent Total N-Nitroso Compounds (ATNC) was monitored throughout fermentations of all-malt ale worts supplemented with nitrate (0–100 mg Litre−1 (0–100 ppm)). The pitching yeasts were obtained from commercial breweries and contained different levels of the contaminant bacterium Obesumbacterium proteus (0–2.1% by number).
J. Calderbank, J. R. M. Hammond
exaly   +2 more sources

Replacement of Nitrite in Meat Products by Natural Bioactive Compounds Results in Reduced Exposure to N-Nitroso Compounds: The PHYTOME Project. [PDF]

Mol Nutr Food Res, 2021
The PHYTOME project develops innovative meat products in which the food additive nitrite was replaced by natural compounds originating from fruits and vegetables. These biologically active compounds (phytochemicals) contribute to improved gut health. Subjects consuming red processed meat enriched with phytochemicals formed lower levels of potentially ...
van Breda SG, Mathijs K, Pieters HJ, Sági-Kiss V, Kuhnle GG, Georgiadis P, Saccani G, Parolari G, Virgili R, Sinha R, Hemke G, Hung Y, Verbeke W, Masclee AA, Vleugels-Simon CB, van Bodegraven AA, de Kok TM, PHYTOME consortium.   +17 more
europepmc   +2 more sources

HDEC: A Heterogeneous Dynamic Ensemble Classifier for Binary Datasets. [PDF]

Comput Intell Neurosci, 2020
In recent years, ensemble classification methods have been widely investigated in both industry and literature in the field of machine learning and artificial intelligence. The main advantage of this approach is to benefit from a set of classifiers instead of using a single classifier with the aim of improving the prediction performance, such as ...
Ostvar N, Eftekhari Moghadam AM.
europepmc   +2 more sources

Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins. [PDF]

Cancer Med
This review comprehensively covers the TRAIL fusion proteins that have been reported in recent years. It also summarizes six commonly employed strategies used in the construction of TRAIL fusion proteins. ABSTRACT Background TNF‐related apoptosis‐inducing ligand (TRAIL) belongs to the tumor necrosis factor superfamily.
Wang Y, Qian X, Wang Y, Yu C, Feng L, Zheng X, Wang Y, Gong Q.   +7 more
europepmc   +2 more sources

Miniaturized and improved method for Apparent Total N-Nitroso Compounds determination in beer

Kvasný průmysl, 2021
A miniaturized and improved method for Apparent Total Nitroso Compounds determination in liquid matrices was developed. The main improvement is based on a miniaturized and modified apparatus for chemical denitrosation of nitroso compounds by hydrogen ...
Tomáš Vrzal, Michaela Malečková, Jana Olšovská   +2 more
doaj   +1 more source

Genetic Variability Impacts Genotoxic and Transcriptome Responses in the Human Colon after the Consumption of Processed Red Meat Products and Those with Added Phytochemical Extracts. [PDF]

Nutrients
The PHYTOME study investigated the effect of consuming processed meat products on outcomes related to colorectal cancer risk without testing the impact of genetic variability on these responses.
DeBenedictis JN, Baars E, Ochoteco-Asensio J, van Breda SG, de Kok TM.   +4 more
europepmc   +2 more sources

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans. [PDF]

Int J Mol Sci, 2019
Consumption of nitrate-rich beetroot juice (BRJ) by athletes induces a number of beneficial physiological health effects, which are linked to the formation of nitric oxide (NO) from nitrate. However, following a secondary pathway, NO may also lead to the
Berends JE, van den Berg LMM, Guggeis MA, Henckens NFT, Hossein IJ, de Joode MEJR, Zamani H, van Pelt KAAJ, Beelen NA, Kuhnle GG, de Kok TMCM, Van Breda SGJ.   +11 more
europepmc   +3 more sources