Results 51 to 60 of about 137,435 (317)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Investigations on strength of piping for non-condensable gas combustion (Part 2: FEM analysis of steel pipes with a valve or an elbow subjected to hydrogen-oxygen detonation)

Nihon Kikai Gakkai ronbunshu, 2015
Carbon steel pipe specimens, which had been experimentally ruptured or deformed by hydrogen-oxygen detonation, were analysed by dynamic analysis using a finite element method (FEM).
Akira NEBU, Koji YAMADA, Koji DOZAKI, Akitaka HIDAKA, Masahiro UCHIDA, Takahiro SONE   +5 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

SOME ISSUES OF THE OBJECTIVE PART OF CORPUS DELICTI IN THE SAFETY NORMS VIOLATION ON THE ATOMIC POWER OBJECTS

Russian Journal of Economics and Law, 2007
The article is dedicated to the analysis of certain signs of the objective part of corpus delicti of the safety regulations violations at the atomic power objects: the deed, its consequences, casual relations between them, crime scene.
R. R. Fazylov
doaj  

Analysis of Steam Line Break Accident Using PCTRAN Model of VVER-1200 NPP

Applications of Modelling and Simulation, 2023
The investigation of thermal-hydraulic parameters during steam-line break (SLB) accidents is performed by applying the personal computer transient analyzer (PCTRAN) simulator model of the VVER-1200 nuclear power plant (NPP). Five cases, namely, 0.005 m2 (
Muhammed Mufazzal Hossen, M. Khalaquzzaman, S. K. Anisur Rahman   +2 more
doaj  

Investigations on strength of piping for non-condensable gas combustion (Part 3: Estimation of fracture strain of steel pipes subjected to hydrogen-oxygen detonation)

Nihon Kikai Gakkai ronbunshu, 2015
To assess the integrity of piping under the detonation pressure of accumulated hydrogen-oxygen, the fracture strain of the pipe material must be identified.
Akira NEBU, Koji YAMADA, Koji DOZAKI, Akitaka HIDAKA, Masahiro UCHIDA, Takahiro SONE   +5 more
doaj   +1 more source

Recent verification activities on probabilistic fracture mechanics analysis code PASCAL4 for reactor pressure vessel

Mechanical Engineering Journal, 2020
Probabilistic fracture mechanics (PFM) is considered a promising methodology in assessing the integrity of structural components in nuclear power plants because it can rationally represent the influence parameters in their probabilistic distributions ...
Kai LU, Jinya KATSUYAMA, Yinsheng LI, Yuhei MIYAMOTO, Takatoshi HIROTA, Yu ITABASHI, Masaki NAGAI, Masahide SUZUKI, Yasuhiro KANTO   +8 more
doaj   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source