Results 91 to 100 of about 105,814 (267)
The role of statin drugs in combating cardiovascular diseases –A review [PDF]
, 2011 Statins clearly confer substantial benefit in people with established cardiovascular (CV) disease. Increased cholesterol levels have been associated with cardiovascular diseases (CVD), and statins are therefore used in the prevention of these diseases ...
Suresh Pichandi , Palanisamy Pasupathi, Y.Yagneswara Rao, Jawahar Farook, Athimoolam Ambika, Babu Shankar Ponnusha , Sathiyamoorthy Subramaniyam, Rajaram Virumandy, Boopathi subramaniyam Int J Cur Sci Res.
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Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib. [PDF]
, 2018 BackgroundEarly detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development.
DeLisle, Robert K +8 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.The Clinical Pharmacogenetics Implementation Consortium (CPIC) has formally updated the SLCO1B1 allele functionality table based on new evidence. Notably, the alleles studied (SLCO1B1 *9, *31, *41) are enriched in the genomes of patients historically excluded from pharmacogenomics research.
Akinyemi Oni‐Orisan +6 more
wiley +1 more source
The effects of atorvastatin in mustard gas exposed patients with chronic obstructive pulmonary disease: A randomized controlled trail [PDF]
Background: Statins have anti-inflammatory effects in patients with chronic obstructive pulmonary disease. This study designed to evaluate the effects of atorvastatin on serum highly sensitive C-reactive protein (hs-CRP) and pulmonary function in ...
قانعی, مصطفی +4 more
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Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION. [PDF]
, 2016 OBJECTIVES: The aim of this study was to assess for a treatment interaction between statin use and exercise training (ET) response. BACKGROUND: Recent data suggest that statins may attenuate ET response, but limited data exist in patients with heart ...
Cooper, Lawton S. +13 more
core +1 more source
A high-throughput screening method for determining the substrate scope of nitrilases [PDF]
, 2014 Nitrile compounds are intermediates in the synthesis of pharmaceuticals such as atorvastatin. We have developed a chromogenic reagent to screen for nitrilase activity as an alternative to Nessler's reagent. It produces a semi-quantifiable blue colour and
Black, Gary +5 more
core +1 more source
Drug Delivery, 2017 Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect ...
Mohammed Elmowafy +5 more
semanticscholar +1 more source
Food Bioengineering, EarlyView.Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi +4 more
wiley +1 more source
Efficacy and Safety of Metformin and Atorvastatin Combination Therapy vs. Monotherapy with Either Drug in Type 2 Diabetes Mellitus and Dyslipidemia Patients (ATOMIC): Double-Blinded Randomized Controlled Trial [PDF]
Diabetes & Metabolism JournalBackground It is well known that a large number of patients with diabetes also have dyslipidemia, which significantly increases the risk of cardiovascular disease (CVD). This study aimed to evaluate the efficacy and safety of combination drugs consisting
Jie-Eun Lee +37 more
doaj +1 more source
Journal of Lipid Research, 2019 Atherosclerosis-related CVD causes nearly 20 million deaths annually. Most patients are treated after plaques develop, so therapies must regress existing lesions. Current therapies reduce plaque volume, but targeting all apoB-containing lipoproteins with
M. Pouwer +7 more
semanticscholar +1 more source