Results 111 to 120 of about 105,814 (267)

Non-adherence to cardiovascular pharmacotherapy in Iraq assessed using 8-items Morisky questionnaire and analysis of dried blood spot samples [PDF]

, 2019
open access journalThe study evaluated the non-adherence to selected cardiovascular medications, atenolol, atorvastatin, bisoprolol, diltiazem, lisinopril, simvastatin and valsartan in Iraqi patients by applying a standardized Morisky questionnaire (8 ...
Alalaqi, Ahmed, Lawson, Graham, Obaid, Yaseen, Tanna, Sangeeta   +3 more
core   +1 more source

Effect of atorvastatin on delirium status of patients in the intensive care unit: a randomized controlled trial

Archives of medical science : AMS, 2019
Introduction Delirium is one of the most prevalent complications in intensive care unit (ICU) patients, which is related to worse clinical outcomes including a longer ICU stay, longer duration of mechanical ventilation, higher mortality rates and ...
S. Sohrevardi, Fatemeh Shojaei Nasab, M. Mirjalili, Mohammad Bagherniya, A. Tafti, Mohammad Hossien Jarrahzadeh, M. Azarpazhooh, Mohsen Saeidmanesh, M. Banach, T. Jamialahmadi, A. Sahebkar   +10 more
semanticscholar   +1 more source

Dermatomyositis Like Presentation of Anti‐HMGCR Immune Mediated Necrotising Myopathy

JEADV Clinical Practice, EarlyView.
ABSTRACT Extramuscular manifestations of anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) immune‐mediated necrotising myopathy (IMNM) are rare and often overlooked because they are overshadowed by predominant muscular symptoms. The types of cutaneous manifestations can be numerous.
Lionel Leblanc, Lyna Mtimet, Louis Wolff, Evelyne Berlingin, Bruno Couturier   +4 more
wiley   +1 more source

Atorvastatin effects on serum level of hs-CRP and lung function in chemical warfare victims with chronic obstructive pulmonary disease. [PDF]

Background: Anti-Infammatory properties of Statins may be beneficial in reduction of airway inflammation and improvement of lung function in patients with chronic obstructive pulmonary disease.
قبادی مراللو, حسن, محمودپور, افسون, پورفرضی, فرهاد   +2 more
core   +1 more source

Role of Regulatory T cells in Atorvastatin Induced Absorption of Chronic Subdural Hematoma in Rats

Aging and Disease, 2019
Chronic subdural hematoma (CSDH) is a neurological disorder with a substantial recurrence rate. Atorvastatin is an effective drug for treating hyperlipidemia and known to improve neurological outcome after intracerebral hemorrhage.
W. Quan, Zhifei Zhang, Pan Li, Qilong Tian, Jinhao Huang, Yu Qian, Chuang Gao, Wanqiang Su, Zengguang Wang, Jian-ning Zhang, A. Zacharek, P. Venkat, Jieli Chen, Rongcai Jiang   +13 more
semanticscholar   +1 more source

Rosuvastatin Upregulates RCOR1 to Repress C10ORF10 Transcription and Alleviate Oxidative Stress and Plaque Formation in Atherosclerosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Rosuvastatin (RVS) is an HMG‐CoA reductase inhibitor with lipid‐lowering properties. This study aims to investigate the role of RVS in plaque formation in atherosclerosis (AS) and its functional mechanism. ApoE−/− mice were fed a high‐fat diet to generate a mouse model of AS.
Xin Fu, Chuang Liu, Ya‐Li Chen, Jie‐Lin Qin, Ting‐Ting Wang, Shan‐Shan Fu   +5 more
wiley   +1 more source

In vitro blood-brain-barrier permeability and cytotoxicity of atorvastatin-loaded nanoformulation against glioblastoma in 2D and 3D models.

Molecular Pharmaceutics, 2019
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase of the family of statins have been suggested as therapeutic options in various tumors.
Michael M. Lübtow, Sabrina Oerter, S. Quader, E. Jeanclos, A. Cubukova, Marion Krafft, M. Haider, C. Schulte, Laura Meier, M. Rist, Oltea Sampetrean, H. Kinoh, A. Gohla, K. Kataoka, A. Appelt-Menzel, R. Luxenhofer   +15 more
semanticscholar   +1 more source

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, EarlyView.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease [PDF]

, 2001
Background - Therapeutic neovascularization may constitute an important strategy to salvage tissue from critical ischemia. Circulating bone marrow–derived endothelial progenitor cells (EPCs) were shown to augment the neovascularization of ischemic tissue.
Adler, K, Aicher, A, Dimmeler, S, Fichtlscherer, S, Martin, H, Vasa, M, Zeiher, AM   +6 more
core   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source