Results 111 to 120 of about 41,587 (192)

Rising Burden and Clinical Impact of Metabolic Syndrome in Inflammatory Bowel Disease: A Real‐World Cohort Study

United European Gastroenterology Journal, Volume 14, Issue 6, July 2026.
ABSTRACT Background Metabolic syndrome (MetS) and its cardiometabolic complications are recognized in inflammatory bowel disease (IBD); however, longitudinal trends and their impact on outcomes remain incompletely defined. We aimed to evaluate temporal trends in cardiometabolic comorbidities and assess the impact of MetS on cardiometabolic, hepatic ...
Raseen Tariq, Kavin Parmar, Mahima Desai, Richard K. Sterling, Arun J. Sanyal   +4 more
wiley   +1 more source

Diagnostic Impact of Liver Biopsy Among Antinuclear Antibody Positive Individuals With Mild Liver Enzyme Elevation

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 103-111, July 2026.
In ANA‐positive patients with suspected autoimmune hepatitis (AIH), liver biopsy rarely altered therapeutic management when alanine aminotransferase (ALT) was below 101 U/L and cirrhosis was absent. These findings suggest that biopsy may be safely deferred in this low‐risk group.
David Mehdi Asgher Niazi, Alphonse Charbel, Jan Pfeiffenberger, Uta Merle, Jessica Seessle, Theresa Wenz, Christa Flechtenmacher, Patrick Michl, Conrad Rauber   +8 more
wiley   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Long‐term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 7, Page 896-902, July 2026.
Summary Introduction Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder associated with an increased risk of cutaneous tumors. Objectives To develop a feasible and easy‐to‐apply treatment regimen for long‐time disease control of DSAP including prevention of new skin tumors. Patients and Methods 19 patients with DSAP
Berenice M. Lang, Gregor Ojak, Mandy Crummenauer, Joanna Wegner, Caroline Mann, Stephan Grabbe, Petra Staubach   +6 more
wiley   +1 more source

Langanhaltende Krankheitskontrolle der disseminierten superfiziellen aktinischen Porokeratose (DSAP) mittels topischer Anwendung von 2% Simvastatin/2% Cholesterin‐Creme

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 7, Page 896-904, July 2026.
Zusammenfassung Einleitung Die disseminierte superfizielle aktinische Porokeratose (DSAP) ist eine seltene Keratinisierungsstörung, die mit einem erhöhten Risiko für kutane Tumoren verbunden ist. Zielsetzung Ziel der Studie war die Entwicklung eines praktikablen und einfach anwendbaren Behandlungsregimes für die langfristige Kontrolle der DSAP ...
Berenice M. Lang, Gregor Ojak, Mandy Crummenauer, Joanna Wegner, Caroline Mann, Stephan Grabbe, Petra Staubach   +6 more
wiley   +1 more source

Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects.
Mar García‐Colomer, José E. Martínez, Luis Díaz‐Gómez, Miriam Sartages, Eva M. Esquinas‐Román, Cristina Riobello, David Martínez‐Delgado, Diego González‐Pérez, Aurora Gómez‐Durán, Miguel Fidalgo, Marta Varela‐Rey, Celia M. Pombo, Juan Zalvide   +12 more
wiley   +1 more source

Clinical, Radiographic, and Histopathologic Features of Human Perigraftitis

Journal of Esthetic and Restorative Dentistry, Volume 38, Issue 7, Page 1300-1314, July 2026.
ABSTRACT Objective Perigraftitis is a biologic complication associated with dental implants placed in grafted bone, distinct from peri‐implant mucositis and peri‐implantitis. This report further characterizes its clinical, radiographic, and histopathologic features.
Jonathan H. Do, Charles M. Cobb, John T. Shen   +2 more
wiley   +1 more source

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, Volume 604, Issue 13, Page 5170-5199, 1 July 2026.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Atorvastatin pre-exposure in hypercholesterolemia remedies 27HC mediated dendritic cell dysfunctions in triple-negative breast cancer. [PDF]

Mol Ther Oncol
Choudhury PR, Chakravarti M, Bera S, Arora P, Sultana J, Khan MA, Biradar R, Guha A, Dhar S, Ghosh I, Ganguly N, Lasure A, Kashyap P, Das J, Mandal B, Das P, Sarkar A, Datta D, Nandi S, Alam N, Baral R, Banerjee S, Bose A.   +22 more
europepmc   +1 more source

An LC-MS/MS Method for Simultaneous Determination of Almonertinib and Atorvastatin: Evaluating Their Drug-Drug Interactions in Rat. [PDF]

Drug Des Devel Ther
Li H, Wu H, Gao S, Cui L, Xu J, Sun J, Liu Z, Wang Z, Tao X.   +8 more
europepmc   +1 more source