Results 31 to 40 of about 105,814 (267)

Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1+/− Mice

Translational Oncology, 2017
Atorvastatin is widely used to lower blood cholesterol and to reduce risk of cardiovascular disease–associated complications. Epidemiological investigations and preclinical studies suggest that statins such as atorvastatin have antitumor activity for ...
Ming Hong Shen, Paulina Samsel, Louise L. Shen, Kalin Narov, Jian Yang, Julian R. Sampson   +5 more
doaj   +1 more source

A mechanistic study on the phototoxicity of atorvastatin: singlet oxygen generation by a phenanthrene-like photoproduct [PDF]

, 2009
Atorvastatin calcium (ATV) is one of the most frequently prescribed drugs worldwide. Among the adverse effects observed for this lipid-lowering agent, clinical cases of cutaneous adverse reactions have been reported and associated with photosensitivity ...
IESCE, MARIA ROSARIA, Lhiaubet Vallet V., Miranda M. A., MONTANARO, SARA, PREVITERA, LUCIO   +4 more
core   +1 more source

Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures

Indonesian Journal of Chemistry, 2017
Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic
Yudi Wicaksono, Budipratiwi Wisudyaningsih, Frida Oktaningtias Widiarthi, Tri Agus Siswoyo   +3 more
doaj   +1 more source

Photochemical behavior of the drug atorvastatin in water. [PDF]

, 2006
Atorvastatin undergoes a self-sensitized photooxygenation by sunlight in water. The main photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means.
CERMOLA, FLAVIO, DELLA GRECA, MARINA, IESCE, MARIA ROSARIA, PREVITERA, LUCIO, S. Montanaro, TEMUSSI, FABIO   +5 more
core   +1 more source

Atorvastatin Solid Lipid Nanoparticles as a Promising Approach for Dermal Delivery and an Anti-inflammatory Agent

AAPS PharmSciTech, 2020
In the current research, the main focus was to overcome dermal delivery problems of atorvastatin. To this end, atorvastatin solid lipid nanoparticles (ATR-SLNs) were prepared by ultra-sonication technique.
Seyed Sadegh Shahraeini, J. Akbari, M. Saeedi, K. Morteza-Semnani, Shidrokh Abootorabi, Milad Dehghanpoor, Seyyed Sohrab Rostamkalaei, A. Nokhodchi   +7 more
semanticscholar   +1 more source

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series. [PDF]

, 2015
Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited.
Cham, Stephanie, Golomb, Beatrice A, Koslik, Hayley J   +2 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: a longitudinal controlled trial of combination therapy. [PDF]

, 2010
A large body of evidence suggests that, besides their cholesterol-lowering effect, statins exert anti-inflammatory action. Consequently, statins may have therapeutic potential in immune-mediated disorders such as multiple sclerosis.
BRESCIA MORRA, VINCENZO, BRUNETTI, ARTURO, CAROTENUTO, BARBARA, LANZILLO, ROBERTA, Lus G, OREFICE, GIUSEPPE, Prinster A, Quarantelli M, RINALDI, CARLO, SALVATORE, ELENA, Spitaleri D, Tedeschi G, Vacca G, Ventrella G   +13 more
core   +1 more source

Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols

Journal of Lipid Research, 2006
Statins do not always decrease coronary heart disease mortality, which was speculated based on increased serum plant sterols observed during statin treatment.
Jogchum Plat, Ilona Beugels, Marion J.J. Gijbels, Menno P.J. de Winther, Ronald P. Mensink   +4 more
doaj   +1 more source

Sphingosine Kinase 1 Plays an Important Role in Atorvastatin-Mediated Anti-Inflammatory Effect against Acute Lung Injury

Mediators of Inflammation, 2021
Atorvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) inhibitor and inhibits cholesterol synthesis. Recently, atorvastatin also showed anti-inflammatory effect in acute lung injury, ameliorating pulmonary gas-blood ...
Lan Wu, Yan Cheng, Shunxiang Peng, Wensheng Zhang, Chaoxiong Zhang   +4 more
doaj   +1 more source