Rapid, Field-Deployable Method for Genotyping and Discovery of Single-Nucleotide Polymorphisms Associated with Drug Resistance in Plasmodium falciparum [PDF]
, 2012 Despite efforts to reduce malaria morbidity and mortality, drug-resistant parasites continue to evade control strategies. Recently, emphasis has shifted away from control and toward regional elimination and global eradication of malaria.
Daniels, Rachel Fath +8 more
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Malaria and the traveller [PDF]
, 2005 Malaria has reached epidemic proportions. About 40% of the world’s population live in malarious areas. It is estimated that 400 million people are infected by malaria each year and of these, 1-3 million die, mostly children under five years of age.
Tonna, Antonella, Tonna, Ivan
core
Effect of farnesyltransferase inhibitor R115777 on mitochondria of plasmodium falciparum [PDF]
The parasite Plasmodium falciparum causes severe malaria and is the most dangerous to humans. However, it exhibits resistance to their drugs. Farnesyltransferase has been identified in pathogenic protozoa of the genera Plasmodium and the target of ...
Ha, YR +4 more
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Preventing malaria in international travellers: an evaluation of published English-language guidelines [PDF]
, 2014 Background People intending to travel may seek information on malaria prevention from a range of sources. To ensure the best protection, this information needs to be reliable, up-to-date, consistent, and useful to their decision making.
Garner, Paul +3 more
core +3 more sources
Lead clinical and pre-clinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations [PDF]
, 2014 To achieve malarial elimination we must employ interventions that reduce the exposure of human populations to infectious mosquitoes. To this end, numerous anti-malarial drugs are under assessment in a variety of transmission-blocking assays which fail to
Blagborough, A.M. +9 more
core +4 more sources
A Poisson hierarchical modelling approach to detecting copy number variation in sequence coverage data. [PDF]
, 2013 BACKGROUND: The advent of next generation sequencing technology has accelerated efforts to map and catalogue copy number variation (CNV) in genomes of important micro-organisms for public health.
Assefa, Samuel A +5 more
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EULAR Rheumatology Open: Objectives: Pneumocystis jirovecii pneumonia (PCP) is a life-threatening complication that occurs in immunocompromised individuals, including patients with connective tissue diseases under glucocorticoid treatments.
Tomoaki Ida +10 more
doaj +1 more source
Artemether-Lumefantrine Treatment Failure despite adequate lumefantrine day 7 Concentration in a Traveller with Plasmodium Falciparum Malaria after Returning from Tanzania. [PDF]
Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa.
Färnert, Anna +6 more
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Infection and Drug Resistance, 2023 Jun Hirai,1,2 Nobuaki Mori,1,2 Hideo Kato,3 Nobuhiro Asai,1,2 Mao Hagihara,4 Hiroshige Mikamo1,2 1Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Nagakute, Aichi, Japan; 2Department of Infection Control and Prevention ...
Hirai J +5 more
doaj
Atovaquone Compared with Dapsone for the Prevention of Pneumocystis carinii Pneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or Both [PDF]
, 1998 BACKGROUND Although trimethoprim–sulfamethoxazole is the drug of choice for the prevention of Pneumocystis carinii pneumonia, many patients cannot tolerate it and must switch to an alternative agent.
Balfour, Henry H., , Jr., M.D. +11 more
core +1 more source