Results 1 to 10 of about 7,683 (208)

Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi‐physiologic population pharmacokinetic approach [PDF]

Clinical and Translational Science
Proguanil, an antimalarial drug, undergoes hepatic uptake by the polymorphic organic cation transporter 1 (OCT1) and is subsequently metabolized by the cytochrome P‐450 2C19 (CYP2C19) enzyme into its active metabolite, cycloguanil.
Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung‐Sang Yu, SeungHwan Lee   +5 more
doaj   +3 more sources

Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis [PDF]

Malaria Journal, 2011
The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported.
Ivanovic Jelena, Gallo Anna L, D'Avolio Antonio, Tempestilli Massimo, Bellagamba Rita, Tommasi Chiara, Nicastri Emanuele, Pucillo Leopoldo P, Narciso Pasquale   +8 more
doaj   +4 more sources

Early treatment failure during treatment of Plasmodium falciparum malaria with atovaquone-proguanil in the Republic of Ivory Coast [PDF]

Malaria Journal, 2012
The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone‐proguanil (Malarone®) has shown high efficacy against Plasmodium falciparum with only mild side ...
Wurtz Nathalie, Pascual Aurélie, Marin-Jauffre Adeline, Bouchiba Housem, Benoit Nicolas, Desbordes Marc, Martelloni Maryse, de Santi Vincent, Richa Georges, Taudon Nicolas, Pradines Bruno, Briolant Sébastien   +11 more
doaj   +2 more sources

Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds [PDF]

Pharmaceuticals
N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin, Anastasiya O. Novikova, Oleg I. Barygin   +2 more
doaj   +2 more sources

Splenic accumulation of intact Plasmodium ovale sensu lato-infected red blood cells in a patient presenting with splenic rupture. [PDF]

PLoS Neglected Tropical Diseases
A 35-year-old man had splenic rupture just after starting antimalarial treatment with atovaquone-proguanil followed by artesunate for acute Plasmodium ovale sensu lato infection. Spleen histology showed a 10-fold accumulation of intact P.
Ghania Benabdelmoumen, Oula Itani, Valentin Joste, Sandrine Houzé, David Hardy, Florent Bavozet, Moussa Sylla, Steven Kho, Nicholas M Anstey, Paul Henri Consigny, Abdoulaye Sissoko, Pierre Buffet   +11 more
doaj   +2 more sources

Congenital babesiosis in China: first molecularly confirmed case of vertical transmission of Babesia microti [PDF]

Emerging Microbes and Infections
Congenital babesiosis is rarely reported globally. We report a 74-day-old male infant presented with fever, pallor, and severe, life-threatening haemolytic anaemia (haemoglobin: 45 g/L).
Junwen Liu, Dongfang Li, Sen Wang, Shuai Gao, Bin Xu, Junlong Zhao, Qin Liu, Muxin Chen, Xiaonong Zhou, Yuchun Cai, Lan He   +10 more
doaj   +2 more sources

Complete attenuation of Plasmodium falciparum sporozoites by atovaquone–proguanil [PDF]

EMBO Molecular Medicine
To develop a Plasmodium falciparum (Pf) vaccine that precludes replication inside the host for improved vaccine safety, we tested chemo-attenuation (CVac) of sporozoites (SPZ) with atovaquone–proguanil (AP). In mice, P.
Steffen Borrmann, Zita Sulyok, Katja Müller, Rolf Fendel, Mihály Sulyok, Johannes Friesen, Albert Lalremruata, Thaisa Lucas Sandri, The Trong Nguyen, Carlos Lamsfus Calle, Annette Knoblich, Stephanie Sefried, Javier Ibáñez, Freia-Raphaella Lorenz, Henri Lynn Heimann, David M Weller, Regina Steuder, Selorme Adukpo, Patricia Granados Bayon, Zsófia Molnár, Meral Esen, Wolfram Metzger, Eric R James, Adam Ruben, Yonas Abebe, Sumana Chakravarty, Anita Manoj, Natasha KC, Tooba Murshedkar, Julius C R Hafalla, Tamirat Gebru Woldearegai, Fiona O’Rourke, Jana Held, Pete Billingsley, B Kim Lee Sim, Thomas L Richie, Stephen L Hoffman, Peter G Kremsner, Kai Matuschewski, Benjamin Mordmüller   +39 more
doaj   +2 more sources

Delayed Onset of Symptoms and Atovaquone-Proguanil Chemoprophylaxis Breakthrough by Plasmodium malariae in the Absence of Mutation at Codon 268 of pmcytb. [PDF]

PLoS Neglected Tropical Diseases, 2015
Plasmodium malariae is widely distributed across the tropics, causing symptomatic malaria in humans with a 72-hour fever periodicity, and may present after latency periods lasting up to many decades.
Beatrix Huei-Yi Teo, Paul Lansdell, Valerie Smith, Marie Blaze, Debbie Nolder, Khalid B Beshir, Peter L Chiodini, Jun Cao, Anna Färnert, Colin J Sutherland   +9 more
doaj   +5 more sources

Malarone treatment failure not associated with previously described mutations in the cytochrome b gene [PDF]

Malaria Journal, 2004
Malarone® (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are associated with mutations at codon 268 of the parasite's ...
Mockenhaupt Frank P, Gruss Holger, Muehlen Marion, Wichmann Ole, Suttorp Norbert, Jelinek Tomas   +5 more
doaj   +3 more sources

Treatment of avian malaria in captive African penguins (Spheniscus demersus) by the combination of atovaquone and proguanil hydrochloride [PDF]

International Journal of Veterinary Science and Medicine
Avian malaria, a vector-borne disease caused by Plasmodium spp., poses significant threats to various bird populations, particularly captive penguins like the endangered African penguin (Spheniscus demersus).
Rossella Samarelli, Nicola Pugliese, Medhat Saleh, Michela Prioletti, Rossana Cordon, Paolo Cavicchio, Dalila Salierno, Giuseppe Crescenzo, Elena Circella, Antonio Camarda   +9 more
doaj   +2 more sources