Results 11 to 20 of about 7,683 (208)

Multiplex LC–MS/MS assay for simultaneous quantification of artesunate and its active metabolite dihydroartemisinin with pyronaridine, proguanil, cycloguanil, and clindamycin in pharmacokinetic studies [PDF]

Malaria Journal
Background Malaria, especially caused by Plasmodium falciparum, remains a major global health concern, particularly in sub-Saharan Africa. To combat rising drug resistance, innovative treatment approaches like triple artemisinin-based combination therapy
Christoph Pfaffendorf, Johannes Mischlinger, Jean Claude Dejon-Agobé, Oumou Maïga-Ascofaré, Ebenezer Ahenkan, Ayôla Akim Adegnika, Michael Ramharter, Sebastian G. Wicha   +7 more
doaj   +2 more sources

Atovaquone-Proguanil: A Promising Therapy for Persistent Relapsing Babesiosis [PDF]

Case Reports in Infectious Diseases
We report a challenging case of persistent relapsing babesiosis in an immunocompromised host that was successfully managed with atovaquone-proguanil (Malarone).
Mahum Shahid, Brendan Wechsler, Vinod Parameswaran, Mark Anthony Diaz   +3 more
doaj   +2 more sources

4-nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy. [PDF]

FEBS Lett
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Verdaguer IB, Santos MF, Filho MM, Castro GO, Hernández A, Peres MA, Katzin AM, Crispim M.   +7 more
europepmc   +2 more sources

Malaria Screening and Treatment in Hematopoietic Cell Transplant Donors and Sickle Cell Disease Candidates/Recipients: A Case Series Using Malaria Polymerase Chain Reaction Testing and a Literature Review. [PDF]

Transpl Infect Dis
Malaria polymerase chain reaction (PCR) testing is more sensitive than conventional diagnostics. Routine PCR screening of at‐risk asymptomatic hematopoietic cell donors and transplant candidates may prevent unnecessary deferrals or treatment. In our experience, PCR negativity during screening or after treatment supports donor/candidate eligibility ...
Czech MM, Das S, Limerick E, Fitzhugh C, Hsieh M, Cuellar-Rodriguez J.   +5 more
europepmc   +2 more sources

Treatment Failure and Post-Artesunate Delayed Haemolysis in a Returned Traveller From Uganda With Partially Drug-Resistant Severe Plasmodium falciparum Malaria. [PDF]

Med J Aust
ABSTRACT A man aged in his 40s, recently returned from Uganda, was hospitalised with Plasmodium falciparum malaria, with hyperparasitaemia of ~1.5 × 106 parasites/μL (26%). He received intravenous artesunate followed by artemether–lumefantrine. However, parasite clearance was delayed, and despite a negative blood film following treatment, the patient ...
Travis J, McCarthy K, Chapman P, Huang L, Tan A, Cheng Q, Barber BE.   +6 more
europepmc   +2 more sources

Anti-plasmodial potential of selected medicinal plants and a compound Atropine isolated from Eucalyptus obliqua

Open Chemistry, 2023
The present research study was aimed to investigate the efficiency of selected medicinal plants against Plasmodium vivax. Crude methanolic extracts from the seeds of leaves of Datura stramonium, Parthenium hysterophorus, Calotropis procera, and Dodonaea ...
Zareen Shehzad, Adnan Muhammad, Khan Shahid Niaz, Alotaibi Amal   +3 more
doaj   +1 more source

Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length

Molecules, 2021
Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the ...
Simeng Xu, Yufang Cao, Yu Luo, Di Xiao, Wei Wang, Zhiren Wang, Xiaoping Yang   +6 more
doaj   +1 more source

Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy

Cell Death and Disease, 2022
A major reason for the high mortality of patients with bladder cancer (BC) is that chemotherapy and surgery are only effective for very limited patients.
Di Xiao, Xin Hu, Mei Peng, Jun Deng, Sichun Zhou, Simeng Xu, Jingtao Wu, Xiaoping Yang   +7 more
doaj   +1 more source

Proguanil and atovaquone use is associated with lower colorectal cancer risk: a nationwide cohort study

BMC Medicine, 2022
Background Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based ...
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji   +3 more
doaj   +1 more source

A Safe and Effective Atovaquone-Proguanil Therapeutic Protocol for the Treatment of Avian Malaria by Plasmodium relictum in Snowy Owl (Bubo scandiacus)

Animals, 2023
Avian malaria is a re-emerging threat to avian species worldwide. It is sustained by several protozoan species belonging to the genus Plasmodium, mainly Plasmodium relictum. The even wider diffusion of the disease, probably because of the increase in the
Nicola Pugliese, Rossella Samarelli, Roberto Lombardi, Antonella Schiavone, Giuseppe Crescenzo, Elena Circella, Claudia Zizzadoro, Olimpia Lai, Medhat S. Saleh, Michela Prioletti, Antonio Camarda   +10 more
doaj   +1 more source