Results 11 to 20 of about 3,493 (156)

Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds [PDF]

Pharmaceuticals
N-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin, Anastasiya O. Novikova, Oleg I. Barygin   +2 more
doaj   +2 more sources

Splenic accumulation of intact Plasmodium ovale sensu lato-infected red blood cells in a patient presenting with splenic rupture. [PDF]

PLoS Neglected Tropical Diseases
A 35-year-old man had splenic rupture just after starting antimalarial treatment with atovaquone-proguanil followed by artesunate for acute Plasmodium ovale sensu lato infection. Spleen histology showed a 10-fold accumulation of intact P.
Ghania Benabdelmoumen, Oula Itani, Valentin Joste, Sandrine Houzé, David Hardy, Florent Bavozet, Moussa Sylla, Steven Kho, Nicholas M Anstey, Paul Henri Consigny, Abdoulaye Sissoko, Pierre Buffet   +11 more
doaj   +2 more sources

Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi‐physiologic population pharmacokinetic approach [PDF]

Clinical and Translational Science
Proguanil, an antimalarial drug, undergoes hepatic uptake by the polymorphic organic cation transporter 1 (OCT1) and is subsequently metabolized by the cytochrome P‐450 2C19 (CYP2C19) enzyme into its active metabolite, cycloguanil.
Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung‐Sang Yu, SeungHwan Lee   +5 more
doaj   +2 more sources

Congenital babesiosis in China: first molecularly confirmed case of vertical transmission of Babesia microti [PDF]

Emerging Microbes and Infections
Congenital babesiosis is rarely reported globally. We report a 74-day-old male infant presented with fever, pallor, and severe, life-threatening haemolytic anaemia (haemoglobin: 45 g/L).
Junwen Liu, Dongfang Li, Sen Wang, Shuai Gao, Bin Xu, Junlong Zhao, Qin Liu, Muxin Chen, Xiaonong Zhou, Yuchun Cai, Lan He   +10 more
doaj   +2 more sources

Complete attenuation of Plasmodium falciparum sporozoites by atovaquone–proguanil [PDF]

EMBO Molecular Medicine
To develop a Plasmodium falciparum (Pf) vaccine that precludes replication inside the host for improved vaccine safety, we tested chemo-attenuation (CVac) of sporozoites (SPZ) with atovaquone–proguanil (AP). In mice, P.
Steffen Borrmann, Zita Sulyok, Katja Müller, Rolf Fendel, Mihály Sulyok, Johannes Friesen, Albert Lalremruata, Thaisa Lucas Sandri, The Trong Nguyen, Carlos Lamsfus Calle, Annette Knoblich, Stephanie Sefried, Javier Ibáñez, Freia-Raphaella Lorenz, Henri Lynn Heimann, David M Weller, Regina Steuder, Selorme Adukpo, Patricia Granados Bayon, Zsófia Molnár, Meral Esen, Wolfram Metzger, Eric R James, Adam Ruben, Yonas Abebe, Sumana Chakravarty, Anita Manoj, Natasha KC, Tooba Murshedkar, Julius C R Hafalla, Tamirat Gebru Woldearegai, Fiona O’Rourke, Jana Held, Pete Billingsley, B Kim Lee Sim, Thomas L Richie, Stephen L Hoffman, Peter G Kremsner, Kai Matuschewski, Benjamin Mordmüller   +39 more
doaj   +2 more sources

Treatment of avian malaria in captive African penguins (Spheniscus demersus) by the combination of atovaquone and proguanil hydrochloride [PDF]

International Journal of Veterinary Science and Medicine
Avian malaria, a vector-borne disease caused by Plasmodium spp., poses significant threats to various bird populations, particularly captive penguins like the endangered African penguin (Spheniscus demersus).
Rossella Samarelli, Nicola Pugliese, Medhat Saleh, Michela Prioletti, Rossana Cordon, Paolo Cavicchio, Dalila Salierno, Giuseppe Crescenzo, Elena Circella, Antonio Camarda   +9 more
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Multiplex LC–MS/MS assay for simultaneous quantification of artesunate and its active metabolite dihydroartemisinin with pyronaridine, proguanil, cycloguanil, and clindamycin in pharmacokinetic studies [PDF]

Malaria Journal
Background Malaria, especially caused by Plasmodium falciparum, remains a major global health concern, particularly in sub-Saharan Africa. To combat rising drug resistance, innovative treatment approaches like triple artemisinin-based combination therapy
Christoph Pfaffendorf, Johannes Mischlinger, Jean Claude Dejon-Agobé, Oumou Maïga-Ascofaré, Ebenezer Ahenkan, Ayôla Akim Adegnika, Michael Ramharter, Sebastian G. Wicha   +7 more
doaj   +2 more sources

Anti-plasmodial potential of selected medicinal plants and a compound Atropine isolated from Eucalyptus obliqua

Open Chemistry, 2023
The present research study was aimed to investigate the efficiency of selected medicinal plants against Plasmodium vivax. Crude methanolic extracts from the seeds of leaves of Datura stramonium, Parthenium hysterophorus, Calotropis procera, and Dodonaea ...
Zareen Shehzad, Adnan Muhammad, Khan Shahid Niaz, Alotaibi Amal   +3 more
doaj   +1 more source

Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy

Cell Death and Disease, 2022
A major reason for the high mortality of patients with bladder cancer (BC) is that chemotherapy and surgery are only effective for very limited patients.
Di Xiao, Xin Hu, Mei Peng, Jun Deng, Sichun Zhou, Simeng Xu, Jingtao Wu, Xiaoping Yang   +7 more
doaj   +1 more source

A Safe and Effective Atovaquone-Proguanil Therapeutic Protocol for the Treatment of Avian Malaria by Plasmodium relictum in Snowy Owl (Bubo scandiacus)

Animals, 2023
Avian malaria is a re-emerging threat to avian species worldwide. It is sustained by several protozoan species belonging to the genus Plasmodium, mainly Plasmodium relictum. The even wider diffusion of the disease, probably because of the increase in the
Nicola Pugliese, Rossella Samarelli, Roberto Lombardi, Antonella Schiavone, Giuseppe Crescenzo, Elena Circella, Claudia Zizzadoro, Olimpia Lai, Medhat S. Saleh, Michela Prioletti, Antonio Camarda   +10 more
doaj   +1 more source