Results 41 to 50 of about 7,683 (208)

Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone

Memorias do Instituto Oswaldo Cruz, 2001
Chloroquine has been the mainstay of malaria chemotherapy for the past five decades, but resistance is now widespread. Pyrimethamine or proguanil form an important component of some alternate drug combinations being used for treatment of uncomplicated ...
Ravi Toteja, Lathika Nair, VK Bhasin
doaj   +1 more source

Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Veterinary Sciences, 2022
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger, Andrea Springer, Marko Legler, Michael Fehr, Christina Strube, Nayden Chakarov   +8 more
doaj   +1 more source

Genetic polymorphism of cytochrome p450 (2C19) enzyme in Iranian Turkman ethnic group [PDF]

, 2013
Objective: Different findings indicate that CYP2C plays a clinical role in determining interindividual and interethnic differences in drug effectiveness. The ethnic differences in the frequency of CYP2C19 mutant alleles continue to be a significant study
Ataby, O.A., Mansourian, A.R., Marjani, A., Samai, N.M., Tabari, R.G.   +4 more
core   +2 more sources

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
A. Llanos-Cuentas, P. Campos, M. Clendenes, C. J. Canfield, D. B. A. Hutchinson   +4 more
doaj   +1 more source

Improved synchronous production of Plasmodium falciparum gametocytes in vitro.

, 2007
The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P.
Baker, David A, Fivelman, Quinton L, McRobert, Louisa, Saeed, Maha, Sharp, Sarah, Sutherland, Colin J, Swales, Claire A, Taylor, Cathy J   +7 more
core   +1 more source

Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola

Malaria Journal, 2006
Background The fixed dose combination atovaquone-proguanil is a recently introduced antimalarial for treatment and prophylaxis of Plasmodium falciparum malaria. It is highly effective with a good tolerability profile and a convenient prophylactic regimen.
Varandas Luís, Bom Joana, Quinhentos Vatúsia, Benchimol Carla, Nogueira Fátima, Pimentel Sónia, do Rosário Virgílio, Bernardino Luís   +7 more
doaj   +1 more source

Lord of the “rings”: A case of Plasmodium falciparum

IDCases, 2022
Plasmodium falciparum is the most common species to result in severe malaria infection. Examination of blood sample with thick and thin smear is the gold standard diagnostic test and repeat peripheral smear monitoring every 12–24 h should be performed ...
Marissa Li, Isin Y. Comba, Allison R. Eberly, Omar M. Abu Saleh   +3 more
doaj   +1 more source

The Epidemiology of Sickle Cell Disease in Sub‐Saharan Africa: Current Knowledge and Gaps to be Filled

American Journal of Hematology, Volume 101, Issue S1, Page 5-16, April 2026.
What are the available data on incidence & prevalence prognosis risk factors of severity of sickle cell disease in sub‐Saharan Africa? ABSTRACT Sickle Cell Disease (SCD) is highly prevalent in sub‐Saharan Africa. Epidemiological data remain sparse, but regional screening and research initiatives are expanding.
Brigitte Ranque, Leon Tshilolo, Thomas N. Williams   +2 more
wiley   +1 more source

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Malaria Journal, 2017
Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs).
Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink   +7 more
doaj   +1 more source

Plasmodium falciparum malaria: rosettes are disrupted by quinine, artemisinin, mefloquine, primaquine, pyrimethamine, chloroquine and proguanil

Memorias do Instituto Oswaldo Cruz, 1999
An assay was developed measuring the disruption of rosettes between Plasmodium falciparuminfected (trophozoites) and uninfected erythrocytes by the antimalarial drugs quinine, artemisinin mefloquine, primaquine, pyrimethamine, chloroquine and proguanil ...
JP Dean Goldring, Thanugarani Padayachee, Imraan Ismail   +2 more
doaj   +1 more source