Results 1 to 10 of about 9,220 (202)
Malaria Journal, 2008 Background Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine.
Fivelman Quinton L +7 more
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Frontiers in Oncology, 2021 Childhood acute lymphoblastic leukaemia (cALL) accounts for about one third of all paediatric malignancies making it the most common cancer in children.
Yordan Sbirkov +11 more
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Antiparasitic Agent Atovaquone [PDF]
Antimicrobial Agents and Chemotherapy, 2002 Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. There
Aaron L, Baggish, David R, Hill
openaire +2 more sources
Transplant Infectious Disease, EarlyView.ABSTRACT Toxoplasmosis has long been recognized as a serious complication in immunocompromised host, particularly those with advanced HIV/AIDS, hematopoietic stem‐cell transplantation (HSCT), solid‐organ transplant (SOT), and hematological malignancies. The rapid expansion of targeted immunomodulators, including chimeric antigen receptor T‐cell (CAR‐T)
Joy Mouanes‐Abelin +6 more
wiley +1 more source
Lack of mitochondrial MutS homolog 1 in Toxoplasma gondii disrupts maintenance and fidelity of mitochondrial DNA and reveals metabolic plasticity. [PDF]
PLoS ONE, 2017 The importance of maintaining the fidelity of the mitochondrial genome is underscored by the presence of various repair pathways within this organelle.
Tamila Garbuz, Gustavo Arrizabalaga
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Disposition of atovaquone in humans [PDF]
Antimicrobial Agents and Chemotherapy, 1997 Atovaquone is an antiprotozoal compound with good in vitro stability against metabolic inactivation. Previous human studies which did not involve radiolabelling had not accounted for a substantial proportion of the dose. The possible metabolism of atovaquone in men was examined in a radiolabelling study involving four healthy male volunteers ...
P E, Rolan +4 more
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Metal–Drug Complexes as Long‐Release Application for Antimalarial PfFNT‐Inhibitors
ChemMedChem, Volume 21, Issue 13, 14 July 2026.P. falciparum formate‐nitrite transporter (PfFNT) inhibitors have emerged as a novel antimalarial class with potent in vivo and liver‐stage activity. Low‐solubility metal–inhibitor complexes were prepared as potential long‐acting injectables.
Finn Tiedjens +4 more
wiley +1 more source
Total Synthesis and Antimalarial Studies of Caelestines A–C
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Total synthesis of caelestines A–C (alkaloids from the Australian ascidian, Aplidium caelestis) was accomplished, constituting the first synthesis of caelestines B and C. Caelestines A–C, with five other novel quinolones, were assessed against Plasmodium falciparum 3D7 and Dd2. Caelestine B was found to be a selective antimalarial alkaloid. Caelestines
Henry S. T. Smith +3 more
wiley +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, Volume 13, Issue 35, 24 June 2026.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Biopolymer silk fibroin (SF) is a great candidate for drug carriers characterized by its tunable biodegradability, and excellent biocompatibility properties. Recently, we have constructed SF-based nano-enabled drug delivery carriers, in which doxorubicin
Li Bin +9 more
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