Results 21 to 30 of about 11,938 (207)

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source

Targeting the Ubiquinol-Reduction (Q_i) Site of the Mitochondrial Cytochrome bc₁ Complex for the Development of Next Generation Quinolone Antimalarials

Biology, 2022
Antimalarials targeting the ubiquinol-oxidation (Qo) site of the Plasmodium falciparum bc1 complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the Qo site. Recent findings showed a
Kangsa Amporndanai, Nattapon Pinthong, Paul M. O’Neill, W. David Hong, Richard K. Amewu, Chandrakala Pidathala, Neil G. Berry, Suet C. Leung, Stephen A. Ward, Giancarlo A. Biagini, S. Samar Hasnain, Svetlana V. Antonyuk   +11 more
doaj   +1 more source

Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations [PDF]

, 2017
The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
A Bell, A Bhattacharya, AP Gorka, AP Grollman, BT Mott, CD Goodman, CJ Canfield, CP Reynolds, D Bansal, D Plouffe, E Lucumi, E-MA Co, ES Akinboye, ESaB Akinboye, F-J Gamo, GR Zimmermann, HJ Painter, Holly Matthews, IK Srivastava, J Feng, J Keiser, J Keiser, Jon Deakin, KT Andrews, L Vivas, LM Sanz, M Read, Maryam Idris-Usman, Matthew Bogyo, May Rajab, MJ Corral, Niroshini J. Nirmalan, PD Radloff, PG Kremsner, PJ Yeh, QL Fivelman, QL Fivelman, R Khositnithikul, S Wein, ST Mariga, T Harasym, T-C Chou, TC Chou, W Wong, Y Hu   +44 more
core   +5 more sources

A Safe and Effective Atovaquone-Proguanil Therapeutic Protocol for the Treatment of Avian Malaria by Plasmodium relictum in Snowy Owl (Bubo scandiacus)

Animals, 2023
Avian malaria is a re-emerging threat to avian species worldwide. It is sustained by several protozoan species belonging to the genus Plasmodium, mainly Plasmodium relictum. The even wider diffusion of the disease, probably because of the increase in the
Nicola Pugliese, Rossella Samarelli, Roberto Lombardi, Antonella Schiavone, Giuseppe Crescenzo, Elena Circella, Claudia Zizzadoro, Olimpia Lai, Medhat S. Saleh, Michela Prioletti, Antonio Camarda   +10 more
doaj   +1 more source

Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions [PDF]

, 2016
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis.
Ben Mamoun, Choukri, Brancato, Jana, Chibucos, Marcus, Colinge, Jacques, Cornillot, Emmanuel, Crabtree, Jonathan, Dwivedi, Ankit, Fraser, Claire M., Frutos, Roger, Gotia, Hanzel T., Hung, Chris, Ifeonu, Olukemi O., Krause, Peter J., Kumar, Vidya, Kumari, Priti, Lawres, Lauren, McCracken, Carrie, Molina, Douglas M., Orvis, Joshua, Ott, Sandy, Pablo, Jozelyn V., Pazzi, Joseph E., Reynes, Christelle, Sadzewicz, Lisa, Sengamalay, Naomi, Shetty, Amol C., Silva, Joana C., Su, Qi, Tallon, Luke, Tretina, Kyle, Usmani-Brown, Sahar, Virji, Azan Z.   +31 more
core   +3 more sources

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K, Taylor, W R J, Mayxay, M, Price, R, Smithuis, F, Guthmann, J P, Barnes, K, Myint, H Y, Adjuik, M, Olliaro, P, Pukrittayakamee, S, Looareesuwan, S, Hien, T T, Farrar, J, Nosten, F, Day, N P J, White, N J   +16 more
core   +2 more sources

Molecular surveillance of mutations in the cytochrome b gene of Plasmodium falciparum in Gabon and Ethiopia

Malaria Journal, 2006
Background Atovaquone is part of the antimalarial drug combination atovaquone-proguanil (Malarone®) and inhibits the cytochrome bc1 complex of the electron transport chain in Plasmodium spp.
Kremsner Peter G, Hailu Asrat, Gebru Tamirat, Kun Jürgen FJ, Grobusch Martin P   +4 more
doaj   +1 more source

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model [PDF]

, 2016
Infections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies.
Baro, Nicholas, Buckee, Caroline, Childs, Lauren M., Daniels, Rachel, Dow, Geoffrey S., Duraisingh, Manoj T., Gerena, Lucia, Kyle, Dennis, Mantel, Pierre-Yves, Marti, Matthias, Mukherjee, Angana, Obaldía III, Nicanor, Otero, William, Volkman, Sarah K., Wirth, Dyann F.   +14 more
core   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil

Parasite, 2005
The efficacy of atovaquone and sulfadiazine was examined alone or in combination for the treatment of mice infected with six Brazilian Toxoplasma gondii strains previously genotyped using the PCR-RFLP assays of the SAG2 gene, in addition to RH strain ...
Alves C.F., Vitor R.W.A.
doaj   +1 more source