Results 41 to 50 of about 11,938 (207)
Malaria Journal, 2017 Background To study within-host selection of resistant parasites, an important factor in the development of resistance to anti-malarial drugs, a mouse model of repeated interrupted malaria treatment (RIT) has been developed. The characteristics of within
Suci Nuralitha +4 more
doaj +1 more source
Antimalarial 4(1H)-pyridones bind to the Qisite of cytochromebc1 [PDF]
, 2015 Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Much of
Antonyuk, SV +10 more
core +1 more source
A review on characteristics and analytical methods of atovaquone – a potent antimalarial agent
Journal of Applied Pharmaceutical Research, 2020 Drugs used in the treatment of malaria that is caused by various plasmosium species i.e. P. falciparum, P. vivax are most irresistible disease throughout the world.
Sanyam Sharma +4 more
doaj +1 more source
A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials [PDF]
, 2016 Objectives: A future treatment for uncomplicated malaria will contain at least one component that exerts a rapid rate of kill (RoK). We describe here the validation and application of a simple, robust and rapid bioluminescence-based assay for the ...
Biagini, Giancarlo +3 more
core +4 more sources
Antiparasitic Agent Atovaquone [PDF]
Antimicrobial Agents and Chemotherapy, 2002 Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. There
Aaron L, Baggish, David R, Hill
openaire +2 more sources
Improved synchronous production of Plasmodium falciparum gametocytes in vitro.
, 2007 The sexual stages of the Plasmodium falciparum life cycle are attractive targets for vaccines and transmission blocking drugs. Difficulties in culturing and obtaining large amounts of sexual stage P.
Baker, David A +7 more
core +1 more source
Delayed Onset of Symptoms and Atovaquone-Proguanil Chemoprophylaxis Breakthrough by Plasmodium malariae in the Absence of Mutation at Codon 268 of pmcytb. [PDF]
, 2015 Plasmodium malariae is widely distributed across the tropics, causing symptomatic malaria in humans with a 72-hour fever periodicity, and may present after latency periods lasting up to many decades.
Beshir, Khalid B +9 more
core +2 more sources
Malaria Journal, 2003 Background Resistance of Plasmodium falciparum to atovaquone in vitro and in vivo has been associated to mutations in the parasite cytochrome b gene. Methods Cultures were sequentially subjected to increasing doses of atovaquone alone or in combination ...
Salanti Ali +3 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Biopolymer silk fibroin (SF) is a great candidate for drug carriers characterized by its tunable biodegradability, and excellent biocompatibility properties. Recently, we have constructed SF-based nano-enabled drug delivery carriers, in which doxorubicin
Li Bin +9 more
doaj +1 more source
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections [PDF]
, 2016 Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently.
Alibana-Clouser, F +38 more
core +4 more sources