Results 61 to 70 of about 11,938 (207)

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging

VIEW, Volume 7, Issue 2, April 2026.
Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao, Jingyu Deng, Qin Li, Tong Xia, Xun Yang, Simei Yang, Changzhen Sun, Xia Xiong, Li Liu   +8 more
wiley   +1 more source

The Protozoan Inhibitor Atovaquone Affects Mitochondrial Respiration and Shows In Vitro Efficacy Against Glucocorticoid-Resistant Cells in Childhood B-Cell Acute Lymphoblastic Leukaemia

Frontiers in Oncology, 2021
Childhood acute lymphoblastic leukaemia (cALL) accounts for about one third of all paediatric malignancies making it the most common cancer in children.
Yordan Sbirkov, Yordan Sbirkov, Tsvetomira Ivanova, Hasan Burnusuzov, Hasan Burnusuzov, Hasan Burnusuzov, Kalina Gercheva, Kevin Petrie, Tino Schenk, Tino Schenk, Victoria Sarafian, Victoria Sarafian   +11 more
doaj   +1 more source

Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives [PDF]

, 2017
We designed and synthesised novel N-substituted 1,3-thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii efficacy. This scaffold was functionalised both at the N1-hydrazine portion with three structurally different moieties ...
Bizzarri, Bruna, Bordón, Claudia, Campestre, Cristina, Carradori, Simone, Chimenti, Paola, DE MONTE, Celeste, Guglielmi, Paolo, Jones Brando, Lorraine, Rivanera, Daniela, Secci, Daniela   +9 more
core   +1 more source

Non‐Specific Interstitial Pneumonia in Anti‐Jo1 Synthetase Syndrome With Probable Gougerot Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Anti‐synthetase syndrome (ASS) is a rare autoimmune disorder of idiopathic inflammatory myopathy spectrum, characterized by the presence of aminoacyl‐tRNA synthetase antibodies, most commonly anti‐Jo‐1. Clinically presents with interstitial lung disease (ILD), myositis, and arthritis, and may be confused with other autoimmune conditions such ...
Ali Gohar, Ozaire Mohammad, Ruman Shahzad, Fatima Arshad, Abdul Rehman Shahid Khan, Hamad Qayyum, Joham Ajmal, Muhammad Husnain Ahmad   +7 more
wiley   +1 more source

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
A. Llanos-Cuentas, P. Campos, M. Clendenes, C. J. Canfield, D. B. A. Hutchinson   +4 more
doaj   +1 more source

The Antimalarial Compound Atovaquone Inhibits Zika and Dengue Virus Infection by Blocking E Protein-Mediated Membrane Fusion

Viruses, 2020
Flaviviruses bear class II fusion proteins as their envelope (E) proteins. Here, we describe the development of an in vitro quantitative mosquito-cell-based membrane-fusion assay for the E protein using dual split proteins (DSPs).
Mizuki Yamamoto, Takeshi Ichinohe, Aya Watanabe, Ayako Kobayashi, Rui Zhang, Jiping Song, Yasushi Kawaguchi, Zene Matsuda, Jun-ichiro Inoue   +8 more
doaj   +1 more source

From Diagnostic Challenge to Clinical Success: Rapid Multiplex PCR Identification of Cryptosporidium in HIV‐Associated Refractory Diarrhea: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Cryptosporidiosis remains a challenge in people with HIV despite its decreased incidence in developed countries. We report a case of severe diarrhea in a person with HIV where Gram stain findings prioritized cryptosporidium in the differential diagnosis.
Yudai Kono, Mayu Arase, Kohei Ukai, Keiko Soneda, Shinya Yamamoto, Kazuhiko Ikeuchi, Eisuke Adachi, Yusuke Nomura, Yoshimi Higurashi, Shinji Izumiyama, Kazuki Honjo, Yu Miyakawa, Sozaburo Ihara, Hiroyuki Abe, Mitsuhiro Fujishiro, Shu Okugawa, Takeya Tsutsumi   +16 more
wiley   +1 more source

Atovaquone and Pibrentasvir Inhibit the SARS-CoV-2 Endoribonuclease and Restrict Infection In Vitro but Not In Vivo

Viruses, 2023
The emergence of SARS-CoV-1 in 2003 followed by MERS-CoV and now SARS-CoV-2 has proven the latent threat these viruses pose to humanity. While the SARS-CoV-2 pandemic has shifted to a stage of endemicity, the threat of new coronaviruses emerging from ...
Troy von Beck, Luis Mena Hernandez, Hongyi Zhou, Katharine Floyd, Mehul S. Suthar, Jeffrey Skolnick, Joshy Jacob   +6 more
doaj   +1 more source

Severity of imported malaria: protective effect of taking malaria chemoprophylaxis [PDF]

, 2013
BACKGROUND: Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to increase the risk of acquiring malaria,
Jaap J van Hellemond, Klaske Vliegenthart-Jongbloed, Mariana de Mendonça Melo, Marlies E van Wolfswinkel, Perry JJ van Genderen, Rob Koelewijn   +5 more
core   +2 more sources