Results 51 to 60 of about 9,220 (202)

In vivo efficacy of combination therapy with albendazole and atovaquone against primary hydatid cysts in mice

European Journal of Clinical Microbiology and Infectious Diseases, 2021
Alveolar echinococcosis (AE) is caused by the larval stage of Echinococcus multilocularis. Chemotherapy for AE involves albendazole (ABZ), which has shown insufficient efficacy. More effective chemotherapy for AE is needed.
Shigehiro Enkai, H. Kouguchi, D. Inaoka, T. Irie, K. Yagi, K. Kita   +5 more
semanticscholar   +1 more source

A review on characteristics and analytical methods of atovaquone – a potent antimalarial agent

Journal of Applied Pharmaceutical Research, 2020
Drugs used in the treatment of malaria that is caused by various plasmosium species i.e. P. falciparum, P. vivax are most irresistible disease throughout the world.
Sanyam Sharma, Rahul Sharma, Arti Devi, Shammy Jindal, Kamya Goyal   +4 more
doaj   +1 more source

Atovaquone and Berberine Chloride Reduce SARS-CoV-2 Replication In Vitro

Viruses, 2021
Epidemic RNA viruses seem to arise year after year leading to countless infections and devastating disease. SARS-CoV-2 is the most recent of these viruses, but there will undoubtedly be more to come. While effective SARS-CoV-2 vaccines are being deployed,
Bruno A. Rodriguez-Rodriguez, Maria G. Noval, M. Kaczmarek, K. Jang, Sara A. Thannickal, Angelica Cifuentes Kottkamp, Rebecca S. Brown, M. Kielian, K. Cadwell, Kenneth A. Stapleford   +9 more
semanticscholar   +1 more source

Atovaquone enhances antitumor efficacy of TCR-T therapy by augmentation of ROS-induced ferroptosis in hepatocellular carcinoma

Cancer Immunology and Immunotherapy
T-cell receptor (TCR) engineered T-cell therapy has recently emerged as a promising adoptive immunotherapy approach for tumor treatment, yet hindered by tumor immune evasion resulting in poor therapeutic efficacy. The introduction of ferroptosis-targeted
Anan Chen, Zhiwu Yu, N. Ma, Xinyu Lu, Yajing Zhang, Weikang Xu, Yiyue Wang, Jiayi Xie, Yuqi Qin, Guoheng Mo, Sha Wu, Jinlin Hou, Wei Zhu   +12 more
semanticscholar   +1 more source

Within-host selection of drug resistance in a mouse model of repeated interrupted treatment of Plasmodium yoelii infection

Malaria Journal, 2017
Background To study within-host selection of resistant parasites, an important factor in the development of resistance to anti-malarial drugs, a mouse model of repeated interrupted malaria treatment (RIT) has been developed. The characteristics of within
Suci Nuralitha, Josephine E. Siregar, Din Syafruddin, Andy I. M. Hoepelman, Sangkot Marzuki   +4 more
doaj   +1 more source

Clinical Efficacy and Safety of Malarone^®, Azithromycin and Artesunate Combination for Treatment of Babesia gibsoni in Naturally Infected Dogs

Animals, 2022
Babesia gibsoni is a tick-borne protozoal blood parasite that may cause hemolytic anemia, thrombocytopenia, lethargy, and/or splenomegaly in dogs. Many drugs have been used in management of canine babesiosis such as monotherapy or combined treatment ...
Martina Karasová, Csilla Tóthová, Bronislava Víchová, Lucia Blaňarová, Terézia Kisková, Simona Grelová, Radka Staroňová, Alena Micháľová, Martin Kožár, Oskar Nagy, Mária Fialkovičová   +10 more
doaj   +1 more source

Atovaquone

Reactions Weekly, 2006
europepmc   +3 more sources

Optimizing Pneumocystis jirovecii Prophylaxis in Immunocompromised Patients: Defining the Clinical Role of Atovaquone

Transplant Infectious Disease, EarlyView.
In a retrospective cohort study of 149 patients receiving atovaquone for PJP prophylaxis, increased usage was related to broader indications, uptake in new patient groups, difficulty tolerating or accessing alternatives, and longer durations used per patient.
To N. Pham, Kelly A. Cairns, Adithi Ramachandra, Susan G. Poole, Carmela E. Corallo, Bradley J. Gardiner   +5 more
wiley   +1 more source

Plasmodium falciparum Mitochondrial Complex III, the Target of Atovaquone, Is Essential for Progression to the Transmissible Sexual Stages

International Journal of Molecular Sciences
The Plasmodium falciparum mitochondrial electron transport chain (mETC) is responsible for essential metabolic pathways such as de novo pyrimidine synthesis and ATP synthesis.
P. Sheokand, S. Pradhan, Andrew E. Maclean, Alexander Mühleip, L. Sheiner   +4 more
semanticscholar   +1 more source

Metal(triphenylphosphine)-atovaquone Complexes: Synthesis, Antimalarial Activity, and Suppression of Heme Detoxification

Inorganic Chemistry
To ascertain the bioinorganic chemistry of metals conjugated with quinones, the complexes [Ag(ATV)(PPh3)2] (1), [Au(ATV)(PPh3)]·2H2O (2), and [Cu(ATV)(PPh3)2] (3) were synthesized by the coordination of the antimalarial naphthoquinone atovaquone (ATV) to
Luana Daniel, Arquímedes Karam, Chris H. J. Franco, Camila Conde, Adrielle Sacramento de Morais, J. Mosnier, Isabelle Fonta, Wilmer Villarreal, B. Pradines, D. R. Moreira, Maribel Navarro   +10 more
semanticscholar   +1 more source