Results 31 to 40 of about 9,220 (202)

Atovaquone: An Inhibitor of Oxidative Phosphorylation as Studied in Gynecologic Cancers

Cancers, 2022
Simple Summary The Warburg effect in cancer cells (high glucose update and lactate release) is an adaptation that is considered a hallmark of most neoplasms. Blocking oxidative phosphorylation is one way to combat carcinogenesis.
A. Kapur, P. Mehta, Aaron D. Simmons, Spencer S. Ericksen, G. Mehta, Sean P. Palecek, M. Felder, Zachary S. Stenerson, A. Nayak, J. Dominguez, M. Patankar, L. Barroilhet   +11 more
semanticscholar   +1 more source

Development and validation of novel method for simultaneous estimation of Atovaquone and Mefloquine hydrochloride in bulk drug using RP-HPLC

Journal of Applied Pharmaceutical Research, 2020
Atovaquone and Mefloquine hydrochloride are well known anti-malarial drugs. Literature survey reveals that there was no method available for the selected drug combination.
Sanyam Sharma, Amar Deep Ankalgi, Rahul Sharma, Arti Devi, Shammy Jindal, Kamya Goyal   +5 more
doaj   +1 more source

Transmissibility of clinically relevant atovaquone-resistant Plasmodium falciparum by anopheline mosquitoes

bioRxiv, 2023
Rising numbers of malaria cases and deaths underscore the need for new interventions. Long-acting injectable medications, such as those now in use for HIV prophylaxis, offer the prospect of a malaria “chemical vaccine”, combining the efficacy of a drug ...
Victoria A. Balta, Deborah Stiffler, Abeer A. Sayeed, A. Tripathi, Rubayet Elahi, G. Mlambo, R. Bakshi, Amanda Dziedzic, A. Jedlicka, E. Nenortas, Keyla Romero-Rodriguez, Matthew A. Canonizado, Alexis Mann, A. Owen, D. Sullivan, S. Prigge, P. Sinnis, T. Shapiro   +17 more
semanticscholar   +1 more source

Investigation of pre-clinical pharmacokinetic parameters of atovaquone nanosuspension prepared using a pH-based precipitation method and its pharmacodynamic properties in a novel artemisinin combination

Journal of Global Antimicrobial Resistance, 2020
Objectives: Recently, a growing resistance to antimalarial drugs such as chloroquine, sulfadoxine–pyrimethamine, artemisinin derivatives and mefloquine has been observed. The pharmacokinetic limitation of the current therapy and multi-drug resistance has
Harsha Kathpalia, Siddhesh Juvekar, Krishnapriya Mohanraj, Mrunal Apsingekar, Supriya Shidhaye   +4 more
doaj   +1 more source

Data on the combined effect of atovaquone, mefloquine, and 3-bromopyruvic acid against Echinococcus multilocularis protoscoleces

Data in Brief, 2022
The dataset presented here is related to a previous research article titled “Mitochondrial Complex III in Larval Stage of Echinococcus multilocularis as a Potential Chemotherapeutic Target and in vivo Efficacy of Atovaquone Against Primary Hydatid Cysts”[
Hirokazu Kouguchi, Shigehiro Enkai, Hiroyuki Matsuyama, Masahito Hidaka, Daniel Ken Inaoka, Kiyoshi Kita, Kinpei Yagi   +6 more
doaj   +1 more source

Targeting the Ubiquinol-Reduction (Q_i) Site of the Mitochondrial Cytochrome bc₁ Complex for the Development of Next Generation Quinolone Antimalarials

Biology, 2022
Antimalarials targeting the ubiquinol-oxidation (Qo) site of the Plasmodium falciparum bc1 complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the Qo site. Recent findings showed a
Kangsa Amporndanai, Nattapon Pinthong, Paul M. O’Neill, W. David Hong, Richard K. Amewu, Chandrakala Pidathala, Neil G. Berry, Suet C. Leung, Stephen A. Ward, Giancarlo A. Biagini, S. Samar Hasnain, Svetlana V. Antonyuk   +11 more
doaj   +1 more source

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer

Clinical Cancer Research, 2021
Purpose: Tumor hypoxia fuels an aggressive tumor phenotype and confers resistance to anticancer treatments. We conducted a clinical trial to determine whether the antimalarial drug atovaquone, a known mitochondrial inhibitor, reduces hypoxia in non–small
M. Skwarski, D. McGowan, E. Belcher, F. Di Chiara, D. Stavroulias, M. McCole, J. Derham, K. Chu, E. Teoh, J. Chauhan, D. O’Reilly, B. Harris, P. Macklin, J. Bull, Marcus Green, G. Rodriguez-Berriguete, R. Prevo, L. Folkes, L. Campo, P. Ferencz, Paula L. Croal, H. Flight, Cathy Qi, J. Holmes, J. O’Connor, F. Gleeson, W. Mckenna, A. Harris, D. Bulte, F. Buffa, R. Macpherson, G. Higgins   +31 more
semanticscholar   +1 more source

A Safe and Effective Atovaquone-Proguanil Therapeutic Protocol for the Treatment of Avian Malaria by Plasmodium relictum in Snowy Owl (Bubo scandiacus)

Animals, 2023
Avian malaria is a re-emerging threat to avian species worldwide. It is sustained by several protozoan species belonging to the genus Plasmodium, mainly Plasmodium relictum. The even wider diffusion of the disease, probably because of the increase in the
Nicola Pugliese, Rossella Samarelli, Roberto Lombardi, Antonella Schiavone, Giuseppe Crescenzo, Elena Circella, Claudia Zizzadoro, Olimpia Lai, Medhat S. Saleh, Michela Prioletti, Antonio Camarda   +10 more
doaj   +1 more source

Use of tafenoquine to treat a patient with relapsing babesiosis with clinical and molecular evidence of resistance to azithromycin and atovaquone

IDCases, 2022
Tafenoquine is a highly effective treatment for Babesia microti infections in animal models. An immunocompromised patient infected by a strain of B.
L. Marcos, Annie Leung, L. Kirkman, G. Wormser   +3 more
semanticscholar   +1 more source

In Vitro Effect of Mitochondria-Targeted Triphenylphosphonium-Based Compounds (Honokiol, Lonidamine, and Atovaquone) on the Platelet Function and Cytotoxic Activity

Frontiers in Pharmacology, 2022
Introduction: Obtaining triphenylphosphonium salts derived from anticancer compounds to inhibit mitochondrial metabolism is of major interest due to their pivotal role in reactive oxygen species (ROS) production, calcium homeostasis, apoptosis, and cell ...
H. Montecino-Garrido, Diego Méndez, R. Araya-Maturana, Juan Pablo Millas-Vargas, S. Wehinger, E. Fuentes   +5 more
semanticscholar   +1 more source