Results 31 to 40 of about 11,938 (207)

Atovaquone attenuates experimental colitis by reducing neutrophil infiltration of colonic mucosa

Frontiers in Pharmacology, 2022
Ulcerative colitis (UC) is a chronic relapsing disease featuring aberrant accumulation of neutrophils in colonic mucosa and the luminal space. Although significant advances in UC therapy have been made with the development of novel biologics and small ...
Laura D. Manzanares, Joseph David, Xingsheng Ren, Lenore K. Yalom, Enzo B. Piccolo, Yalda Dehghan, Aidan J. David, Stephen B. Hanauer, Ronen Sumagin   +8 more
doaj   +1 more source

In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand

Malaria Journal, 2008
Background The emergence of Plasmodium falciparum resistant to most currently used antimalarial drugs is the major problem in malaria control along the Thai-Myanmar and Thai-Cambodia borders.
Mungthin Mathirut, Tan-ariya Peerapan, Khositnithikul Rommanee   +2 more
doaj   +1 more source

Clinically relevant atovaquone-resistant human malaria parasites fail to transmit by mosquito

Nature Communications, 2023
Long-acting injectable medications, such as atovaquone, offer the prospect of a “chemical vaccine” for malaria, combining drug efficacy with vaccine durability. However, selection and transmission of drug-resistant parasites is of concern.
Victoria A. Balta, Deborah Stiffler, Abeer Sayeed, Abhai K. Tripathi, Rubayet Elahi, Godfree Mlambo, Rahul P. Bakshi, Amanda G. Dziedzic, Anne E. Jedlicka, Elizabeth Nenortas, Keyla Romero-Rodriguez, Matthew A. Canonizado, Alexis Mann, Andrew Owen, David J. Sullivan, Sean T. Prigge, Photini Sinnis, Theresa A. Shapiro   +17 more
doaj   +1 more source

Imaging carbonic anhydrase IX as a method for monitoring hypoxia-related radioresistance in preclinical head and neck cancer models

Physics and Imaging in Radiation Oncology, 2021
Background and purpose: Tumor hypoxia is an important cause of radioresistance and is associated with poor outcome.SPECT (Single-photon emission computed tomography) imaging enables visualizing tumor characteristics. We investigated the SPECT-radiotracer
Fokko J. Huizing, Bianca A.W. Hoeben, Jasper Lok, Otto C. Boerman, Sandra Heskamp, Johan Bussink   +5 more
doaj   +1 more source

Atovaquone

Reactions Weekly, 2006
europepmc   +3 more sources

Late clinical failure associated with cytochrome b codon 268 mutation during treatment of falciparum malaria with atovaquone–proguanil in traveller returning from Congo

Malaria Journal, 2020
Background The drug combination atovaquone–proguanil, is recommended for treatment of uncomplicated falciparum malaria in France. Despite high efficacy, atovaquone–proguanil treatment failures have been reported.
Laurencie Massamba, Marylin Madamet, Nicolas Benoit, Alicia Chevalier, Isabelle Fonta, Véronique Mondain, Pierre-Yves Jeandel, Rémy Amalvict, Pascal Delaunay, Joel Mosnier, Pierre Marty, Christelle Pomares, Bruno Pradines   +12 more
doaj   +1 more source

Atovaquone-HSA nano-drugs enhance the efficacy of PD-1 blockade immunotherapy by alleviating hypoxic tumor microenvironment

Journal of Nanobiotechnology, 2021
Background Hypoxia is inherent character of most solid malignancies, leading to the failure of chemotherapy, radiotherapy and immunotherapy. Atovaquone, an anti-malaria drug, can alleviate tumor hypoxia by inhibiting mitochondrial complex III activity ...
Simeng Wang, Xinrui Zhou, Zekun Zeng, Mengjun Sui, Lihong Chen, Chao Feng, Chen Huang, Qi Yang, Meiju Ji, Peng Hou   +9 more
doaj   +1 more source

Hair concentrations of anti-malarials in returned travellers-the HAIR study: Proof of principle analysis

Travel Medicine and Infectious Disease, 2023
Background: Hair analysis to identify substance use is an established methodology. This could also be a method to monitor adherence to antimalarial drugs.
Regula Steiner, Anne Kaulich, Daniel Müller, Patricia Schlagenhauf   +3 more
doaj   +1 more source

Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction [PDF]

, 2010
Background Drug resistance determination for Plasmodium falciparum infections are important to determining the type of treatment to be given. Besides in vivo experiments, molecular methods, such as sequencing and PCR, are now increasingly being used ...
Linda Gan, Jin Loh
core   +2 more sources

Early treatment failure during treatment of Plasmodium falciparum malaria with atovaquone-proguanil in the Republic of Ivory Coast [PDF]

, 2012
The increased spread of drug-resistant malaria highlights the need for alternative drugs for treatment and chemoprophylaxis. The combination of atovaquone‐proguanil (Malarone®) has shown high efficacy against Plasmodium falciparum with only mild side ...
Adeline Marin-Jauffre, Aurélie Pascual, Bruno Pradines, Georges Richa, Housem Bouchiba, Marc Desbordes, Maryse Martelloni, Nathalie Wurtz, Nicolas Benoit, Nicolas Taudon, Sébastien Briolant, Vincent de Santi   +11 more
core   +1 more source