Results 81 to 90 of about 11,938 (207)

Malaria Screening and Treatment in Hematopoietic Cell Transplant Donors and Sickle Cell Disease Candidates/Recipients: A Case Series Using Malaria Polymerase Chain Reaction Testing and a Literature Review

Transplant Infectious Disease, Volume 28, Issue 1, January/February 2026.
Malaria polymerase chain reaction (PCR) testing is more sensitive than conventional diagnostics. Routine PCR screening of at‐risk asymptomatic hematopoietic cell donors and transplant candidates may prevent unnecessary deferrals or treatment. In our experience, PCR negativity during screening or after treatment supports donor/candidate eligibility ...
Mary M. Czech, Sanchita Das, Emily Limerick, Courtney Fitzhugh, Matthew Hsieh, Jennifer Cuellar‐Rodriguez   +5 more
wiley   +1 more source

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases, 2001
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
Llanos-Cuentas A., Campos P., Clendenes M., Canfield C. J., Hutchinson D. B. A.   +4 more
doaj  

Progression of Malaria in the Human Body, Its Effects on the Liver and Its Various Aspects

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Malaria, an infectious disease caused by Plasmodium parasites, is a significant global health issue, particularly in tropical and subtropical regions. Understanding the development of malaria in the human body and its effects on vital organs like the liver is crucial for effective control and prevention.
Avishek Mandal, Sanmoy Karmakar, Mithun Bhowmick, Sweet Naskar, Ankita Sadhukhan, Arnab Sarkar, Prativa Bhowmick, Jiong Yu   +7 more
wiley   +1 more source

Efficacy and Tolerability of Antimalarials and Molecular Resistance Markers of Falciparum Malaria in Jimma Region, Ethiopia [PDF]

, 2011
Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries.
Eshetu, Teferi
core  

Bispecific Antibodies in Hematologic Malignancies in the Outpatient and Community Settings

Advances in Hematology, Volume 2026, Issue 1, 2026.
Bispecific antibodies (BsAbs) are novel antitumor agents that simultaneously engage tumor‐associated antigens with CD3 on endogenous effector T cells, leading to cancer cell death. The immune‐mediated toxicity rates associated with BsAbs are considerably lower than those seen with CAR T‐cell therapy.
Amrit S. Gonugunta, Asad Haider, Virginia Mohlere, Mahmoud Aljurf, Shahrukh Hashmi, Muhammad Bilal Abid, Paschalis Evangelidis   +6 more
wiley   +1 more source

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties

Molecules, 2017
With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring
Karène Urgin, Mouhamad Jida, Katharina Ehrhardt, Tobias Müller, Michael Lanzer, Louis Maes, Mourad Elhabiri, Elisabeth Davioud-Charvet   +7 more
doaj   +1 more source

Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Background Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Samson Anjikwi Malgwi, Samuel Chima Ugbaja, Moses Okpeku, Harleen Khatra   +5 more
wiley   +1 more source

Transfusion-Associated Babesiosis after Heart Transplant

Emerging Infectious Diseases, 2003
We describe a 54-year-old spleen-intact man with transfusion-associated Babesia microti infection after a heart transplant. Adult respiratory distress syndrome developed in the patient, and he required mechanical ventilation.
Joseph Z. Lux, Don Weiss, Jeanne V. Linden, Debra Kessler, Barbara L. Herwaldt, Susan J. Wong, Jan Keithly, Phyllis Della-Latta, Brian E. Scully   +8 more
doaj   +1 more source

Identification of pathogen genomic variants through an integrated pipeline [PDF]

, 2014
Background: Whole-genome sequencing represents a powerful experimental tool for pathogen research. We present methods for the analysis of small eukaryotic genomes, including a streamlined system (called Platypus) for finding single nucleotide and copy ...
Bopp, Selina ER, Bright, Andrew Taylor, Corey, Victoria C, Flannery, Erika L, Manary, Micah J, McNamara, Case W, Singhakul, Suriya S, Walker, John R, Winzeler, Elizabeth A   +8 more
core   +3 more sources

Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling

Memorias do Instituto Oswaldo Cruz
BACKGROUND Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding ...
Ana Carolina Rennó Sodero, Bárbara Abrahim-Vieira, Pedro Henrique Monteiro Torres, Pedro Geraldo Pascutti, Célia RS Garcia, Vitor Francisco Ferreira, David Rodrigues da Rocha, Sabrina Baptista Ferreira, Floriano Paes Silva Jr   +8 more
doaj   +1 more source