Results 51 to 60 of about 7,683 (208)

Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase. [PDF]

, 2016
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic
Agip, Ahmed-Noor A, Bridges, Hannah R, Hirst, Judy, Sirviö, Ville A   +3 more
core   +1 more source

Progression of Malaria in the Human Body, Its Effects on the Liver and Its Various Aspects

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Malaria, an infectious disease caused by Plasmodium parasites, is a significant global health issue, particularly in tropical and subtropical regions. Understanding the development of malaria in the human body and its effects on vital organs like the liver is crucial for effective control and prevention.
Avishek Mandal, Sanmoy Karmakar, Mithun Bhowmick, Sweet Naskar, Ankita Sadhukhan, Arnab Sarkar, Prativa Bhowmick, Jiong Yu   +7 more
wiley   +1 more source

Developing Ontology Support for Human Malaria Control Initiatives [PDF]

, 2009
Malaria is one of the most common infectious diseases and an enormous public health problem in Sub-Sahara Africa, Asia and parts of America. In this paper, we discuss the development of the Human Malaria Control Ontology (HMCO) which contains general ...
Daramola Olawande, Fatumo Segun
core   +1 more source

Unveiling Antimalarial Drug Resistance: The Role of CRISPR‐Cas Technologies in Malaria Research

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2026, Issue 1, 2026.
Background Malaria, caused by Plasmodium parasites, remains a global health burden, with drug resistance threatening control efforts. CRISPR‐Cas technologies, particularly CRISPR‐Cas9, have transformed malaria research by enabling precise genetic manipulations to study antimalarial resistance mechanisms, develop novel therapeutics and enhance ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Moses Okpeku, Jess Vergis   +3 more
wiley   +1 more source

Developing Ontology Support for Human Malaria Control Initiatives [PDF]

, 2011
Malaria is one of the most common infectious diseases and an enormous public health problem in Sub-Sahara Africa, Asia and parts of America. In this paper, we discuss the development of the Human Malaria Control Ontology (HMCO) which contains ...
Daramola, Olawande, Fatumo, S.
core  

Malaria: 11‐Year Experience With Imported Cases at a German University Hospital and Epidemiological Trends Amid the COVID‐19 Pandemic

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Background By the mid‐20th century, Europe eradicated endemic malaria. However, the significance of imported infections in nonendemic regions is growing. These cases often constitute the majority, can sustain transmission, trigger relapses, and increase mortality in these areas. Methods We conducted a retrospective, single‐center study of patients with
Patricia Mester, Claudia Kunst, Stephan Schmid, Katharina Zimmermann, Sigrid Bülow, Janine Rennert, Benedikt M. J. Lampl, Tobias Schilling, Martina Müller, Vlad Pavel, Satabdi Datta Choudhury   +10 more
wiley   +1 more source

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases, 2001
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
Llanos-Cuentas A., Campos P., Clendenes M., Canfield C. J., Hutchinson D. B. A.   +4 more
doaj  

Plasmodium falciparum Malaria and Atovaquone-Proguanil Treatment Failure

Emerging Infectious Diseases, 2008
We noticed overrepresentation of atovaquone-proguanil therapeutic failures among Plasmodium falciparum–infected travelers weighing >100 kg. We report here 1 of these cases, which was not due to resistant parasites or impaired drug bioavailability.
Rémy Durand, Virginie Prendki, Johann Cailhol, Véronique Hubert, Pascal Ralaimazava, Laurent Massias, Olivier Bouchaud, Jacques Le Bras   +7 more
doaj   +1 more source

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

Frontiers in Pharmacology, 2018
The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri, Roberto Würth, Alessandra Pattarozzi, Ivan Verduci, Chiara Mazzola, Maria G. Cattaneo, Michele Tonelli, Agnese Solari, Adriana Bajetto, Antonio Daga, Lucia M. Vicentini, Michele Mazzanti, Tullio Florio, Tullio Florio   +13 more
doaj   +1 more source

Analysis of Global Research on Malaria and Plasmodium vivax [PDF]

, 2019
Background: Malaria is one of the infectious diseases of greatest interest to the scientific community and of greatest concern to international health authorities.
Cebrián Carmona, José, Garrido Cárdenas, José Antonio, González Cerón, Lilia, Manzano Agugliaro, Francisco, Mesa Valle, Concepción   +4 more
core   +1 more source