Results 71 to 80 of about 7,683 (208)

Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa

Malaria Journal, 2006
Background In vitro and in vivo resistance of Plasmodium falciparum to atovaquone or atovaquone-proguanil hydrochloride combination has been associated to two point mutations in the parasite cytochrome b (cytb) gene (Tyr268Ser and Tyr268Asn).
Kyle Dennis E, Sowunmi Akintunde, Sarr Ousmane, Milner Danny, Folarin Onikepe A, Gbotosho Grace O, Happi Christian T, Milhous Wilbur K, Wirth Dyann F, Oduola Ayoade MJ   +9 more
doaj   +1 more source

Penicillium‐Derived Inhibitors of Plasmodium falciparum Lactate Dehydrogenase (PfLDH): A Computational Approach for Novel Antimalarial Therapy Development

Scientifica, Volume 2025, Issue 1, 2025.
Malaria remains a major global health challenge, necessitating the discovery of novel therapeutic agents. This study investigates secondary metabolites from Penicillium spp. as potential inhibitors of Plasmodium falciparum lactate dehydrogenase (PfLDH), a critical enzyme in the parasite’s glycolytic pathway.
Imran Sama-ae, Pimthip Muengthongon, Azeezah Tohlaeh, Watcharaphon Rukhachan, Pawika Kiattikul, Fathiyah Samaeng, Aritsara Mitklin, Md. Atiar Rahman, Aman Tedasen, Pattamaporn Kwankaew, Manas Kotepui, Anirut Kepan, Simone Carradori   +12 more
wiley   +1 more source

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
Truncation of the dihydroquinazolinone scaffold produced analogues with potent antimalarial activity against the asexual blood and transmission stages of the malaria parasite's lifecycle by targeting PfATP4. Enhancing the metabolic stability and aqueous solubility remains a challenge to achieve curative efficacy in a mouse model to demonstrate the ...
Trent D. Ashton, Petar P. S. Calic, Madeline G. Dans, Zi Kang Ooi, Qingmiao Zhou, Katie Loi, Kate E. Jarman, Josephine Palandri, Deyun Qiu, Adele M. Lehane, Bikash Maity, Nirupam De, Mufuliat T. Famodimu, Michael J. Delves, Emma Y. Mao, Maria R. Gancheva, Danny W. Wilson, Mrittika Chowdury, Tania F. de Koning‐Ward, Delphine Baud, Stephen Brand, Paul F. Jackson, Alan F. Cowman, Brad E. Sleebs   +23 more
wiley   +1 more source

"Pyrimethamine and Proguanil Resistance-Conferring Key Mutations in Dihydrofolate Reductase Gene of Plasmodium falciparum Isolates from Iran" [PDF]

Iranian Journal of Public Health, 2003
Using mutation specific PCR assay and analysis of position 108 amino acid in dihydrofolate reductase-thymidilate synthase gene in 70 Plasmodium falciparum isolates of malarial patients from southern areas of Iran, showed 4 different situations: iwild ...
AA Eskandarian, H Keshavarz, F Mahboudi
doaj   +2 more sources

In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand [PDF]

, 1997
The in vitro activities of the new biguanide PS-15 and its putative active metabolite, WR99210, were determined against seven different isolates or clones of Plasmodium falciparum.
Bahr, S, Edstein, MD, Kotecka, B, Rieckmann, KH, Shanks, GD   +4 more
core  

Folic acid treatment of Zambian children with moderate to severe malaria anemia. [PDF]

, 2006
Whether administration of folic acid to children with malaria anemia is helpful is controversial. Therefore, we conducted a randomised, placebo-controlled trial of 14 days of treatment with folic acid (1 mg/d) in Zambian children with malaria anemia ...
Bennett, Steve, Fielding, Katherine, Greenwood, Brian, Malunga, Phidelis, Mulenga, Modest, Shulman, Caroline, Thuma, Philip   +6 more
core   +2 more sources

Virtue ethics and the unsettled ethical questions in controlled human infection studies

Bioethics, Volume 38, Issue 8, Page 692-701, October 2024.
Abstract Controlled human infection studies (CHIs) involve the intentional infection of human subjects for a scientific aim. Though some past challenge trials have involved serious ethical abuses, in the last few decades, CHIs have had a strong track record of safety.
Jeffrey T. Poomkudy, Seema K. Shah
wiley   +1 more source

Efficacy and Tolerability of Antimalarials and Molecular Resistance Markers of Falciparum Malaria in Jimma Region, Ethiopia [PDF]

, 2011
Due to increasing drug resistance, artemisinin-based combination chemotherapy (ACT) has become the first-line treatment of falciparum malaria in many endemic countries.
Eshetu, Teferi
core  

Exposure to anti-malarial drugs and monitoring of adverse drug reactions using toll-free mobile phone calls in private retail sector in Sagamu, Nigeria: implications for pharmacovigilance [PDF]

, 2011
Background Adverse drug reactions (ADRs) contribute to ill-health or life-threatening outcomes of therapy during management of infectious diseases. The exposure to anti-malarial and use of mobile phone technology to report ADRs following drug exposures ...
Ahmed A Adedeji, Bilqees Sanusi, Azeez Tella, Motunrayo Akinsanya, Olubusola Ojo, Mufliat O Akinwunmi, Olubukola A Tikare, Isiaka A Ogunwande, Omobola A Ogundahunsi, Olajide O Ayilara, Taofeeqah T Ademola, Fatai A Fehintola, Olumide AT Ogundahunsi   +12 more
core   +2 more sources

The Effect of Malaria on Responses to Unrelated Vaccines in Animals and Humans: A Systematic Review and Meta‐Analysis

Parasite Immunology, Volume 46, Issue 10, October 2024.
ABSTRACT Vaccine efficacy varies globally, often showing reduced immune responses in low‐ and middle‐income countries, possibly due to the immunomodulatory effects of parasitic infections like malaria. This systematic review evaluates the impact of malaria on immune responses to unrelated vaccines in humans and animals.
Ludoviko Zirimenya, Agnes Natukunda, Jacent Nassuuna, Joyce Kabagenyi, Gyaviira Nkurunungi, Alison M. Elliott, Emily L. Webb   +6 more
wiley   +1 more source