Results 31 to 40 of about 7,683 (208)

Investigation of pre-clinical pharmacokinetic parameters of atovaquone nanosuspension prepared using a pH-based precipitation method and its pharmacodynamic properties in a novel artemisinin combination

Journal of Global Antimicrobial Resistance, 2020
Objectives: Recently, a growing resistance to antimalarial drugs such as chloroquine, sulfadoxine–pyrimethamine, artemisinin derivatives and mefloquine has been observed. The pharmacokinetic limitation of the current therapy and multi-drug resistance has
Harsha Kathpalia, Siddhesh Juvekar, Krishnapriya Mohanraj, Mrunal Apsingekar, Supriya Shidhaye   +4 more
doaj   +1 more source

Proguanil as malaria chemoprophylaxis in sickle cell anaemia: the controversies, problems and the future: A narrative of literature

Nigerian Journal of Paediatrics, 2021
Aim: In Nigeria, proguanil is the recommended drug for malaria chemoprophylaxis in persons with sickle cell anaemia (SCA); however, over the years, studies have given controversial reports on the effectiveness of proguanil as chemoprophylaxis.
Enato Izehiuwa G, Israel-Aina Yetunde T
doaj  

Plasmodium knowlesi Infection in Traveler Returning to Canada from the Philippines, 2023

Emerging Infectious Diseases, 2023
A 55-year-old man sought treatment for an uncomplicated febrile illness after returning to Canada from the Philippines. A suspected diagnosis of Plasmodium knowlesi infection was confirmed by PCR, and treatment with atovaquone/proguanil brought ...
Calvin Ka-Fung Lo, Katherine Plewes, Sakuntla Sharma, Alicia Low, LingHui D. Su, Sara Belga, Ferdinand V. Salazar, Jan Hajek, Muhammad Morshed, Catherine A. Hogan   +9 more
doaj   +1 more source

Deciphering Hepatic Dilemmas: A Case of Acute Hepatitis Following Malaria Treatment. [PDF]

Case Rep Gastrointest Med
Malaria can be a life‐threatening disease, but it rarely presents with acute hepatitis. This case reports the medical course of a 55‐year‐old African woman afflicted with P. falciparum malaria, recently treated in Cameroon, who presented with jaundice and transaminitis. Her liver biopsy indicated cholestatic hepatitis.
Lovrien S, Quist E, Maita Coronel D, Singal AK, Xie C.   +4 more
europepmc   +2 more sources

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. [PDF]

, 2004
To determine the optimum duration of follow-up for the assessment of drug efficacy against Plasmodium falciparum malaria, 96 trial arms from randomized controlled trials (RCTs) with follow-up of 28 days or longer that were conducted between 1990 and 2003
Stepniewska, K, Taylor, W R J, Mayxay, M, Price, R, Smithuis, F, Guthmann, J P, Barnes, K, Myint, H Y, Adjuik, M, Olliaro, P, Pukrittayakamee, S, Looareesuwan, S, Hien, T T, Farrar, J, Nosten, F, Day, N P J, White, N J   +16 more
core   +2 more sources

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. [PDF]

, 2014
Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues.
Borboa, Rachel, Campo, Brice, Chatterjee, Arnab K, Chen, Zhong, Diagana, Thierry T, Gagaring, Kerstin, Glynne, Richard J, Klooster, Els J, Kocken, Clemens HM, Kuhen, Kelli, Leroy, Didier, Luty, Adrian, McNamara, Case W, Nagle, Advait, Plouffe, David M, Remarque, Edmond J, Roland, Jason, Sauerwein, Robert, Thomas, Alan W, van Amsterdam, Sandra M, van den Berg, Alexander, van Gemert, Geert-Jan, Voorberg-van der Wel, Annemarie, Winzeler, Elizabeth A, Yeung, Bryan KS, Zeeman, Anne-Marie   +25 more
core   +1 more source

A Randomized Trial to Compare the Safety, Tolerability, and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease. [PDF]

, 2015
BACKGROUND: Malaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of ...
Affara, Muna, Bello, Surajudeen, Bojang, Kalifa, Ernest, Kolade, Greenwood, Brian, Ibrahim, Olayinka, Kiechel, Jean-René, Lambe, Tosin, Milligan, Paul, Mokuolu, Olugbenga, Murtala, Rukayat, Nwakanma, Davis, Ogunkunle, Taofik, Ojuawo, Ayotade, Olagunju, Tope, Olaosebikan, Rasaq, Olorunsola, Benedict, Omefe, Peter, Rehman, Andrea M   +18 more
core   +2 more sources

PBPK-Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT Treatment of breastfeeding mothers with malaria is challenging due to the lack of information describing drug exposure in milk and the daily dose to the breastfed infant. Physiologically based pharmacokinetic (PBPK) modeling was used to predict milk‐to‐plasma (M/P) ratios, infant daily doses (IDD) and relative infant doses (RID) for five ...
Almond LM, Abduljalil K, Pansari A, Kusmider B, Jones HM, Rowland Yeo K, Gardner I, Faisal M, Marrast AC, El Gaaloul M, Möhrle JJ, Abla N.   +11 more
europepmc   +2 more sources

Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil

Malaria Journal, 2008
Background Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine.
Fivelman Quinton L, Burke Martina, Price Nicholas, Laundy Matt, Sutherland Colin J, Pasvol Geoffrey, Klein John L, Chiodini Peter L   +7 more
doaj   +1 more source

Hyper-reactive Malarial Splenomegaly (HMS) in a patient with ,'' thalassaemia syndrome

The Pan African Medical Journal, 2014
This report describes a case of hyper-reactive malarial splenomegaly in a patient with a thalassaemia syndrome. Increased haemoglobin A2 is valuable for the diagnosis of common forms of ''-thalassemia, while haemoglobin F (HbF) helps in diagnosis of the ...
Yaw Ampem Amoako, George Bedu-Addo
doaj   +1 more source