Results 31 to 40 of about 3,493 (156)

Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis

Malaria Journal, 2011
The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported.
Ivanovic Jelena, Gallo Anna L, D'Avolio Antonio, Tempestilli Massimo, Bellagamba Rita, Tommasi Chiara, Nicastri Emanuele, Pucillo Leopoldo P, Narciso Pasquale   +8 more
doaj   +1 more source

Hyper-reactive Malarial Splenomegaly (HMS) in a patient with ,'' thalassaemia syndrome

The Pan African Medical Journal, 2014
This report describes a case of hyper-reactive malarial splenomegaly in a patient with a thalassaemia syndrome. Increased haemoglobin A2 is valuable for the diagnosis of common forms of ''-thalassemia, while haemoglobin F (HbF) helps in diagnosis of the ...
Yaw Ampem Amoako, George Bedu-Addo
doaj   +1 more source

Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil

Malaria Journal, 2008
Background Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine.
Fivelman Quinton L, Burke Martina, Price Nicholas, Laundy Matt, Sutherland Colin J, Pasvol Geoffrey, Klein John L, Chiodini Peter L   +7 more
doaj   +1 more source

Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola

Malaria Journal, 2006
Background The fixed dose combination atovaquone-proguanil is a recently introduced antimalarial for treatment and prophylaxis of Plasmodium falciparum malaria. It is highly effective with a good tolerability profile and a convenient prophylactic regimen.
Varandas Luís, Bom Joana, Quinhentos Vatúsia, Benchimol Carla, Nogueira Fátima, Pimentel Sónia, do Rosário Virgílio, Bernardino Luís   +7 more
doaj   +1 more source

Tolerability of Atovaquone—Proguanil Application in Common Buzzard Nestlings

Veterinary Sciences, 2022
Differences in drug tolerability among vertebrate groups and species can create substantial challenges for wildlife and ex situ conservation programmes.
Anja Wiegmann, Tony Rinaud, Meinolf Ottensmann, Oliver Krüger, Andrea Springer, Marko Legler, Michael Fehr, Christina Strube, Nayden Chakarov   +8 more
doaj   +1 more source

The Determination of Proguanil

Journal of Pharmacy and Pharmacology, 1949
Summary Two methods are described for the determination of proguanil hydrochloride: one method depends upon titration with perchloric acid in glacial acetic acid solution, and the other upon gravimetric determination of the copper-complex precipitated from cold aqueous solution by ammoniacal cupric chloride.
openaire   +2 more sources

Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru

Brazilian Journal of Infectious Diseases
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (MalaroneTM) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru.
A. Llanos-Cuentas, P. Campos, M. Clendenes, C. J. Canfield, D. B. A. Hutchinson   +4 more
doaj   +1 more source

Genome comparison of progressively drug resistant Plasmodium falciparum lines derived from drug sensitive clone

Memorias do Instituto Oswaldo Cruz, 2001
Chloroquine has been the mainstay of malaria chemotherapy for the past five decades, but resistance is now widespread. Pyrimethamine or proguanil form an important component of some alternate drug combinations being used for treatment of uncomplicated ...
Ravi Toteja, Lathika Nair, VK Bhasin
doaj   +1 more source

Lord of the “rings”: A case of Plasmodium falciparum

IDCases, 2022
Plasmodium falciparum is the most common species to result in severe malaria infection. Examination of blood sample with thick and thin smear is the gold standard diagnostic test and repeat peripheral smear monitoring every 12–24 h should be performed ...
Marissa Li, Isin Y. Comba, Allison R. Eberly, Omar M. Abu Saleh   +3 more
doaj   +1 more source

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Malaria Journal, 2017
Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs).
Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink   +7 more
doaj   +1 more source