Results 21 to 30 of about 7,683 (208)

Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]

, 2020
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M, Bryce, RA, Burusco, KK, Fernández-Álvaro, E, Gutnov, A, Matthews, H, Nirmalan, NJ, Panwar, P, Wilkinson, JA   +8 more
core   +3 more sources

Hair concentrations of anti-malarials in returned travellers-the HAIR study: Proof of principle analysis

Travel Medicine and Infectious Disease, 2023
Background: Hair analysis to identify substance use is an established methodology. This could also be a method to monitor adherence to antimalarial drugs.
Regula Steiner, Anne Kaulich, Daniel Müller, Patricia Schlagenhauf   +3 more
doaj   +1 more source

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

Frontiers in Pharmacology, 2021
The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response.
Bridget L. Morse, Lisa Hong Chen, John T. Catlow, John K. Fallon, Philip C. Smith, Kathleen M. Hillgren   +5 more
doaj   +1 more source

Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial.

PLoS Medicine, 2022
BackgroundChildren with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention. Chemoprevention regimens vary between countries, and the comparative efficacy of prevention regimens is
Steve M Taylor, Sarah Korwa, Angie Wu, Cynthia L Green, Betsy Freedman, Sheila Clapp, Joseph Kipkoech Kirui, Wendy P O'Meara, Festus M Njuguna   +8 more
doaj   +1 more source

Cost-effectiveness analysis of malaria chemoprophylaxis for travellers to West-Africa [PDF]

, 2010
Background: The importation of malaria to non-endemic countries remains a major cause of travel-related morbidity and a leading cause of travel-related hospitalizations. Currently they are three priority medications for malaria prophylaxis to West Africa:
Widmer, Lukas L, Blank, Patricia R, Van Herck, Koen, Hatz, Christoph, Schlagenhauf, Patricia   +4 more
core   +3 more sources

Late clinical failure associated with cytochrome b codon 268 mutation during treatment of falciparum malaria with atovaquone–proguanil in traveller returning from Congo

Malaria Journal, 2020
Background The drug combination atovaquone–proguanil, is recommended for treatment of uncomplicated falciparum malaria in France. Despite high efficacy, atovaquone–proguanil treatment failures have been reported.
Laurencie Massamba, Marylin Madamet, Nicolas Benoit, Alicia Chevalier, Isabelle Fonta, Véronique Mondain, Pierre-Yves Jeandel, Rémy Amalvict, Pascal Delaunay, Joel Mosnier, Pierre Marty, Christelle Pomares, Bruno Pradines   +12 more
doaj   +1 more source

Clinical and parasitological response to oral chloroquine and primaquine in uncomplicated human Plasmodium knowlesi infections [PDF]

, 2013
Background: Plasmodium knowlesi is a cause of symptomatic and potentially fatal infections in humans. There are no studies assessing the detailed parasitological response to treatment of knowlesi malaria infections in man and whether antimalarial ...
Cox Singh, Janet, Daneshvar, Cyrus, Davis, Timothy M. E., Divis, Paul C. S., Rafa'ee, Mohammad Z., Singh, Balbir, Zakaria, Siti K.   +6 more
core   +1 more source

In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand

Malaria Journal, 2008
Background The emergence of Plasmodium falciparum resistant to most currently used antimalarial drugs is the major problem in malaria control along the Thai-Myanmar and Thai-Cambodia borders.
Mungthin Mathirut, Tan-ariya Peerapan, Khositnithikul Rommanee   +2 more
doaj   +1 more source

Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations [PDF]

, 2017
The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
A Bell, A Bhattacharya, AP Gorka, AP Grollman, BT Mott, CD Goodman, CJ Canfield, CP Reynolds, D Bansal, D Plouffe, E Lucumi, E-MA Co, ES Akinboye, ESaB Akinboye, F-J Gamo, GR Zimmermann, HJ Painter, Holly Matthews, IK Srivastava, J Feng, J Keiser, J Keiser, Jon Deakin, KT Andrews, L Vivas, LM Sanz, M Read, Maryam Idris-Usman, Matthew Bogyo, May Rajab, MJ Corral, Niroshini J. Nirmalan, PD Radloff, PG Kremsner, PJ Yeh, QL Fivelman, QL Fivelman, R Khositnithikul, S Wein, ST Mariga, T Harasym, T-C Chou, TC Chou, W Wong, Y Hu   +44 more
core   +5 more sources

Genetic and genomic approaches for the discovery of parasite genes involved in antimalarial drug resistance [PDF]

, 2013
The biggest threat to the war on malaria is the continued evolution of drug resistance by the parasite. Resistance to almost all currently available antimalarials now exists in Plasmodium falciparum which causes the most suffering among all human malaria
Mwangi, J.M., Ranford-Cartwright, L.C.
core   +1 more source