Results 21 to 30 of about 3,493 (156)

Proguanil and atovaquone use is associated with lower colorectal cancer risk: a nationwide cohort study

BMC Medicine, 2022
Background Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical studies suggest that the anti-malaria drug proguanil and atovaquone might play a role in preventing CRC, but population-based ...
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji   +3 more
doaj   +1 more source

Synthesis, Anti-Proliferative Evaluation and Mechanism of 4-Trifluoro Methoxy Proguanil Derivatives with Various Carbon Chain Length

Molecules, 2021
Among the known biguanide drugs, proguanil has the best antiproliferative activity. In contrast, newly synthesized biguanide derivatives containing fluorine atoms have excellent biological activity, among which trifluoromethoxy compounds show the ...
Simeng Xu, Yufang Cao, Yu Luo, Di Xiao, Wei Wang, Zhiren Wang, Xiaoping Yang   +6 more
doaj   +1 more source

Hair concentrations of anti-malarials in returned travellers-the HAIR study: Proof of principle analysis

Travel Medicine and Infectious Disease, 2023
Background: Hair analysis to identify substance use is an established methodology. This could also be a method to monitor adherence to antimalarial drugs.
Regula Steiner, Anne Kaulich, Daniel Müller, Patricia Schlagenhauf   +3 more
doaj   +1 more source

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

Frontiers in Pharmacology, 2021
The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response.
Bridget L. Morse, Lisa Hong Chen, John T. Catlow, John K. Fallon, Philip C. Smith, Kathleen M. Hillgren   +5 more
doaj   +1 more source

Monthly sulfadoxine/pyrimethamine-amodiaquine or dihydroartemisinin-piperaquine as malaria chemoprevention in young Kenyan children with sickle cell anemia: A randomized controlled trial.

PLoS Medicine, 2022
BackgroundChildren with sickle cell anemia (SCA) in areas of Africa with endemic malaria transmission are commonly prescribed malaria chemoprevention. Chemoprevention regimens vary between countries, and the comparative efficacy of prevention regimens is
Steve M Taylor, Sarah Korwa, Angie Wu, Cynthia L Green, Betsy Freedman, Sheila Clapp, Joseph Kipkoech Kirui, Wendy P O'Meara, Festus M Njuguna   +8 more
doaj   +1 more source

Late clinical failure associated with cytochrome b codon 268 mutation during treatment of falciparum malaria with atovaquone–proguanil in traveller returning from Congo

Malaria Journal, 2020
Background The drug combination atovaquone–proguanil, is recommended for treatment of uncomplicated falciparum malaria in France. Despite high efficacy, atovaquone–proguanil treatment failures have been reported.
Laurencie Massamba, Marylin Madamet, Nicolas Benoit, Alicia Chevalier, Isabelle Fonta, Véronique Mondain, Pierre-Yves Jeandel, Rémy Amalvict, Pascal Delaunay, Joel Mosnier, Pierre Marty, Christelle Pomares, Bruno Pradines   +12 more
doaj   +1 more source

In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand

Malaria Journal, 2008
Background The emergence of Plasmodium falciparum resistant to most currently used antimalarial drugs is the major problem in malaria control along the Thai-Myanmar and Thai-Cambodia borders.
Mungthin Mathirut, Tan-ariya Peerapan, Khositnithikul Rommanee   +2 more
doaj   +1 more source

Investigation of pre-clinical pharmacokinetic parameters of atovaquone nanosuspension prepared using a pH-based precipitation method and its pharmacodynamic properties in a novel artemisinin combination

Journal of Global Antimicrobial Resistance, 2020
Objectives: Recently, a growing resistance to antimalarial drugs such as chloroquine, sulfadoxine–pyrimethamine, artemisinin derivatives and mefloquine has been observed. The pharmacokinetic limitation of the current therapy and multi-drug resistance has
Harsha Kathpalia, Siddhesh Juvekar, Krishnapriya Mohanraj, Mrunal Apsingekar, Supriya Shidhaye   +4 more
doaj   +1 more source

Proguanil as malaria chemoprophylaxis in sickle cell anaemia: the controversies, problems and the future: A narrative of literature

Nigerian Journal of Paediatrics, 2021
Aim: In Nigeria, proguanil is the recommended drug for malaria chemoprophylaxis in persons with sickle cell anaemia (SCA); however, over the years, studies have given controversial reports on the effectiveness of proguanil as chemoprophylaxis.
Enato Izehiuwa G, Israel-Aina Yetunde T
doaj  

Plasmodium knowlesi Infection in Traveler Returning to Canada from the Philippines, 2023

Emerging Infectious Diseases, 2023
A 55-year-old man sought treatment for an uncomplicated febrile illness after returning to Canada from the Philippines. A suspected diagnosis of Plasmodium knowlesi infection was confirmed by PCR, and treatment with atovaquone/proguanil brought ...
Calvin Ka-Fung Lo, Katherine Plewes, Sakuntla Sharma, Alicia Low, LingHui D. Su, Sara Belga, Ferdinand V. Salazar, Jan Hajek, Muhammad Morshed, Catherine A. Hogan   +9 more
doaj   +1 more source