Results 101 to 110 of about 106,444 (303)

Adaptive laboratory evolution of a genome-reduced Escherichia coli. [PDF]

, 2019
Synthetic biology aims to design and construct bacterial genomes harboring the minimum number of genes required for self-replicable life. However, the genome-reduced bacteria often show impaired growth under laboratory conditions that cannot be ...
Cho, Byung-Kwan, Cho, Suhyung, Choe, Donghui, Hwang, Soonkyu, Kim, Sun Chang, Lee, Jun Hyoung, Palsson, Bernhard, Sung, Bong Hyun, Yoo, Minseob   +8 more
core   +2 more sources

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

NSUN5 Attenuates Renal Injury and Ferroptosis in Hyperuricaemic Nephropathy Through YBX2‐Dependent Stabilisation of SCD1 m5C Methylation

Advanced Science, EarlyView.
NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song, Xiao‐guo Suo, Yue Yu, Kuo Zhang, Chen‐ao Li, Jie Wang, Hui‐xia Xu, Si‐yu Niu, Dong‐xue Lv, Zi‐hao He, Feng‐he Li, Xiao‐ming Meng, Juan Jin   +12 more
wiley   +1 more source

The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64) in BRIN-BD11 insulinoma cells [PDF]

, 2016
No abstract ...
Borges Pinto, Joana, Graham, Annette
core   +4 more sources

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production

Frontiers in Microbiology, 2018
We report the frequent, convergent loss of two genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains.
Matthias Steglich, Matthias Steglich, Julia D. Hofmann, Julia D. Hofmann, Julia Helmecke, Julia Helmecke, Johannes Sikorski, Cathrin Spröer, Thomas Riedel, Thomas Riedel, Boyke Bunk, Boyke Bunk, Jörg Overmann, Jörg Overmann, Jörg Overmann, Meina Neumann-Schaal, Meina Neumann-Schaal, Meina Neumann-Schaal, Ulrich Nübel, Ulrich Nübel, Ulrich Nübel   +20 more
doaj   +1 more source

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna, Chowdhury, Shafiqul I., Daus, Franz, Heemskerk, Mirjam H. M., Koch, Joachim, Koppers-Lalic, Danijela, Lipinska, Andrea D., Loch, Sandra, Marcondes Rezende, Marisa, Mettenleiter, Thomas C., Neefjes, Jacques J., Osterrieder, Nikolaus, Quinten, Edwin, Reits, Eric A., Ressing, Maaike E., Rijsewijk, Frans A. M., Tampé, Robert, Verweij, Marieke C., Wang, Ying, Wiertz, Emmanuel J. H. J.   +19 more
core  

Energetics and Mechanism of Drug Transport Mediated by the Lactococcal Multidrug Transporter LmrP [PDF]

, 1996
The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion mediated by LmrP were studied in membrane vesicles of E. coli. LmrP-mediated
Bolhuis, Henk,, Brands, Jan Roel,, Driessen, Arnold J.M.,, Konings, Wil N.,, Poolman, Bert,, Putman, Monique,, Veen, Hendrik W. van,   +6 more
core   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Bacterial nitrate assimilation: gene distribution and regulation [PDF]

, 2011
In the context of the global nitrogen cycle, the importance of inorganic nitrate for the nutrition and growth of marine and freshwater autotrophic phytoplankton has long been recognized.
Andrew J. Gates, Assumpção, Caballero, Cabello, Chai, Chen, Conrado Moreno-Vivián, David J. Richardson, Flores, Forchhammer, Forchhammer, Gates, Gutierrez, Ishida, Kayumov, Koropatkin, Leigh, Li, Lin, Lledó, Llácer, M. Dolores Roldán, Moreno-Vivián, Nakano, Ogawa, Ohashi, Pawlowski, Paz-Yepes, Pino, Puerta-Fernández, Ramos, Richardson, Sanders, Shao, Shu, Shu, Stuart J. Ferguson, Swanson, Szeto, Toukdarian, Víctor M. Luque-Almagro, Weiss, Weiss, Wray, Wu   +44 more
core   +1 more source