Results 81 to 90 of about 106,444 (303)

Twenty years of ATP-binding cassette (ABC) transporters [PDF]

Pflügers Archiv - European Journal of Physiology, 2006
ATP-binding cassette (ABC) transporters constitute a large superfamily of primary active transport systems, which play a diversity of physiological roles, and are found in all cells of all kingdoms [3]. The year 2006 marks the 20th anniversary of the identification of this superfamily of proteins in 1986 [4].
Stieger, Bruno, Higgins, Christopher F
openaire   +3 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerols⃞

Journal of Lipid Research, 2007
The highly branched mammalian lung relies on surfactant, a mixture of phospholipids, cholesterol, and hydrophobic proteins, to reduce intraalveolar surface tension and prevent lung collapse.
Michael L. Fitzgerald, Ramnik Xavier, Kathleen J. Haley, Ruth Welti, Julie L. Goss, Cari E. Brown, Debbie Z. Zhuang, Susan A. Bell, Naifang Lu, Mary Mckee, Brian Seed, Mason W. Freeman   +11 more
doaj   +1 more source

ABCA1 is an extracellular phospholipid translocase

Nature Communications, 2022
ATP-binding cassette transporter A1 (ABCA1) drives phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I, for the production of high density lipoprotein (HDL).
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke   +6 more
doaj   +1 more source

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G., Colotti, Gianni, Fazi, Francesco, Genovese, Ilaria, Ilari, Andrea   +4 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum

Communications Biology, 2018
Elizabeth Egan and colleagues demonstrate that host ATP binding cassette transporter ABCB6, which encodes the Langereis blood group antigen, promotes erythrocyte invasion by the malaria parasite Plasmodium falciparum.
Elizabeth S. Egan, Michael P. Weekes, Usheer Kanjee, Jale Manzo, Ashwin Srinivasan, Christine Lomas-Francis, Connie Westhoff, Junko Takahashi, Mitsunobu Tanaka, Seishi Watanabe, Carlo Brugnara, Steven P. Gygi, Yoshihiko Tani, Manoj T. Duraisingh   +13 more
doaj   +1 more source

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source