Results 71 to 80 of about 65,458 (307)

Funktionelle Rekonstitution des menschlichen lysosomale Peptid-Transporter TAPL zeigt die Substratspezifität [PDF]

, 2009
The transporter associated with antigen processing-like (TAPL) acts as a lysosomal ATP-dependent polypeptide transporter with broad length selectivity. To characterize in detail its substrate specificity, a procedure for solubilization, purification and ...
Zhao, Chenguang
core  

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

W546 stacking disruption traps the human porphyrin transporter ABCB6 in an outward-facing transient state

Communications Biology, 2023
Human ATP-binding cassette transporter subfamily B6 (ABCB6) is a mitochondrial ATP-driven pump that translocates porphyrins from the cytoplasm into mitochondria for heme biosynthesis.
Sang Soo Lee, Jun Gyou Park, Eunhong Jang, Seung Hun Choi, Subin Kim, Ji Won Kim, Mi Sun Jin   +6 more
doaj   +1 more source

Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea [PDF]

, 2009
The grey mould fungus Botrytis cinerea causes losses of commercially important fruits, vegetables and ornamentals worldwide. Fungicide treatments are effective for disease control, but bear the risk of resistance development.
Pradier Jean-Marc, Pradier, J.M., Walker, Anne-Sophie, Mernke, Dennis, Pradier, Jean Marc, J. M., Leroux, Pierre, Matthias Hahn, Matthias Kretschmer, Sabine Fillinger, Walker, Anne Sophie, Kretschmer, M., Hahn, Matthias, Fillinger Sabine, Jean-Marc Pradier, Mosbach, Andreas, Walker, A.S., Mernke, Denis, Kretschmer Matthias, Mernke, D., Fillinger, S., de Waard, Maarten A, Maarten A De Waard, Walker, Anne Sophie, A. S., Leroux, P., de Waard, M.A., De Waard Maarten A., Leroux Pierre, Fillinger-David, Sabine, Helma, S. H., Anne-Sophie Walker, Pierre Leroux, Waard, Maarten A. De, Schoonbeek, Henk-jan, Leroch, Michaela, Leroch, M., Pradier, Jean Marc, Leroux, Pierre, P., Mosbach, A., Waard, M.A., de, Dennis Mernke, Pradier, Jean-Marc, Hahn Matthias, Leroch Michaela, Walker Anne-Sophie, Schoonbeek Henk-Jan, Fillinger-David, Sabine, Helma, Henk-Jan Schoonbeek, Mernke Dennis, Fillinger, Sabine, Mosbach Andreas, Andreas Mosbach, Michaela Leroch, Kretschmer, Matthias, Schoonbeek, H.J., Hahn, M.   +53 more
core   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Der katalytische Zyklus der Nukleotid-bindenden Domäne des ABC-Transporters HlyB [PDF]

, 2005
Nucleotide-binding domains (NBDs), roughly 27 kDa in size, are conservative components of the large family of ABC (ATP-binding cassette) transporters, which includes importers, exporters, and receptors.
Zaitseva, Jelena
core  

Structural Features of the ATP-Binding Cassette (ABC) Transporter ABCA3 [PDF]

, 2015
In this review we reported and discussed the structural features of the ATP-Binding Cassette (ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to obtain a reliable structural model of this important transporter.
Alessandro Paolini, Andrea Masotti, Antonella Baldassarre, Ilaria Del Gaudio   +3 more
core   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice[S]

Journal of Lipid Research, 2009
We conducted a genome-wide screen using the mutagen N-ethyl-N-nitrosourea to identify recessive mutations in genes that lead to altered lipid traits in mice.
Todd Juan, Murielle M. Véniant, Joan Helmering, Philip Babij, Daniel M. Baker, Michael A. Damore, Michael B. Bass, Tibor Gyuris, Mark Chhoa, Chi-Ming Li, Chris Ebeling, Julie Amato, George A. Carlson, David J. Lloyd   +13 more
doaj   +1 more source

MOESM7 of Structural and functional insights into the Diabrotica virgifera virgifera ATP-binding cassette transporter gene family [PDF]

, 2019
Additional file 7.
Folukemi Adedipe (3508040), Marcé Lorenzen (8056631), Brian Wiegmman (8056628), Brad Coates (575729), Nathaniel Grubbs (397043)   +4 more
core   +1 more source