Results 81 to 90 of about 105,612 (201)

Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor αs⃞

Journal of Lipid Research, 2007
The oxysterol-activated nuclear receptor liver X receptor α (LXRα) has been implicated in the control of both cholesterol and fatty acid metabolism.
Jelske N. van der Veen, Rick Havinga, Vincent W. Bloks, Albert K. Groen, Folkert Kuipers   +4 more
doaj   +1 more source

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]

, 2008
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna, Chowdhury, Shafiqul I., Daus, Franz, Heemskerk, Mirjam H. M., Koch, Joachim, Koppers-Lalic, Danijela, Lipinska, Andrea D., Loch, Sandra, Marcondes Rezende, Marisa, Mettenleiter, Thomas C., Neefjes, Jacques J., Osterrieder, Nikolaus, Quinten, Edwin, Reits, Eric A., Ressing, Maaike E., Rijsewijk, Frans A. M., Tampé, Robert, Verweij, Marieke C., Wang, Ying, Wiertz, Emmanuel J. H. J.   +19 more
core  

Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production

Frontiers in Microbiology, 2018
We report the frequent, convergent loss of two genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains.
Matthias Steglich, Matthias Steglich, Julia D. Hofmann, Julia D. Hofmann, Julia Helmecke, Julia Helmecke, Johannes Sikorski, Cathrin Spröer, Thomas Riedel, Thomas Riedel, Boyke Bunk, Boyke Bunk, Jörg Overmann, Jörg Overmann, Jörg Overmann, Meina Neumann-Schaal, Meina Neumann-Schaal, Meina Neumann-Schaal, Ulrich Nübel, Ulrich Nübel, Ulrich Nübel   +20 more
doaj   +1 more source

Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]

, 2017
Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K., Kanojia, N., Kukal, S., Kukreti, R., Kukreti, S., Saso, L.   +5 more
core   +2 more sources

Transcriptomic and phosphoproteomic profiling and metabolite analyses reveal the mechanism of NaHCO3-induced organic acid secretion in grapevine roots

BMC Plant Biology, 2019
Background Organic acid secretion is a widespread physiological response of plants to alkalinity. However, the characteristics and underlying mechanism of the alkali-induced secretion of organic acids are poorly understood.
Guangqing Xiang, Wanyun Ma, Shiwei Gao, Zhongxin Jin, Qianyu Yue, Yuxin Yao   +5 more
doaj   +1 more source

Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins [PDF]

, 2011
Background: The Gram-negative bacterium Haemophilus influenzae is a glutathione auxotroph and acquires the redox-active tripeptide by import. The dedicated glutathione transporter belongs to the ATP-binding cassette (ABC)-transporter superfamily and ...
Vergauwen, Bjorn, Van der Meeren, Ruben, Dansercoer, Ann, Savvides, Savvas   +3 more
core   +1 more source

Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii

Nature Communications, 2017
The tripartite multidrug efflux pump MacA-MacB-TolC in Gram-negative bacterial pathogens is driven by the ATPase MacB, which belongs to the ATP-binding cassette (ABC) superfamily.
Ui Okada, Eiki Yamashita, Arthur Neuberger, Mayu Morimoto, Hendrik W. van Veen, Satoshi Murakami   +5 more
doaj   +1 more source

Gene identification for the cblD defect of vitamin B12 metabolism [PDF]

, 2008
Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the ...
Baumgartner, M R, Coelho, D, Fowler, B, Lerner-Ellis, J P, Newbold, R F, Rosenblatt, D S, Stucki, M, Suormala, T   +7 more
core   +1 more source

Energetics and Mechanism of Drug Transport Mediated by the Lactococcal Multidrug Transporter LmrP [PDF]

, 1996
The gene encoding the secondary multidrug transporter LmrP of Lactococcus lactis was heterologously expressed in Escherichia coli. The energetics and mechanism of drug extrusion mediated by LmrP were studied in membrane vesicles of E. coli. LmrP-mediated
Bolhuis, Henk,, Brands, Jan Roel,, Driessen, Arnold J.M.,, Konings, Wil N.,, Poolman, Bert,, Putman, Monique,, Veen, Hendrik W. van,   +6 more
core   +1 more source

Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter [PDF]

, 1967
Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects.
Brunak, Søren, Halasz, Melinda, Huber, Kilian V.M., Kolch, Walter, Papamarkou, Theodore, Radic-Sarikas, Branka, Superti-Furga, Giulio, Tsafou, Kalliopi P., Winter, Georg E.   +8 more
core   +3 more sources