ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species [PDF]
Journal of Lipid Research, 2021 The cytosolic-oriented glucosylceramide (GlcCer) synthase is enigmatic, requiring nascent GlcCer translocation to the luminal Golgi membrane to access glycosphingolipid (GSL) anabolic glycosyltransferases. The mechanism by which GlcCer is flipped remains
Monique Budani +2 more
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The impact of ATP-binding cassette transporters on metabolic diseases [PDF]
Nutrition & Metabolism, 2020 Currently, many people worldwide suffer from metabolic diseases caused by heredity and external factors, such as diet. One of the symptoms of metabolic diseases is abnormal lipid metabolism.
Zixiang Ye, Yifei Lu, Tao Wu
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Predicting ATP-Binding Cassette Transporters Using the Random Forest Method [PDF]
Frontiers in Genetics, 2020 ATP-binding cassette (ABC) proteins play important roles in a wide variety of species. These proteins are involved in absorbing nutrients, exporting toxic substances, and regulating potassium channels, and they contribute to drug resistance in cancer ...
Ruiyan Hou +3 more
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DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network [PDF]
Frontiers in Cell and Developmental Biology, 2021 ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules.
Zhaoxi Zhang +3 more
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Identification and Characterization of ATP-Binding Cassette Transporters in Chlamydomonas reinhardtii [PDF]
Marine Drugs, 2022 Microalgae are promising microorganisms used to produce value-added products or to develop sustainable approaches for environmental remediation.
Xiangyu Li +5 more
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Expression of some ATP-binding cassette transporters in acute myeloid leukemia [PDF]
Hematology Reports, 2017 Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to ...
Antonella Maria Salvia +8 more
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Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancer [PDF]
IJU Case ReportsIntroduction In addition to reduced nectin‐4 expression, the upregulation of ATP‐binding cassette transporters has been suggested as a potential mechanism of resistance to enfortumab vedotin.
Mariko Kotono +9 more
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Structural View of Cryo-Electron Microscopy-Determined ATP-Binding Cassette Transporters in Human Multidrug Resistance [PDF]
BiomoleculesATP-binding cassette (ABC) transporters, acting as cellular “pumps,” facilitate solute translocation through membranes via ATP hydrolysis. Their overexpression is closely tied to multidrug resistance (MDR), a major obstacle in chemotherapy and ...
Wenjie Fan, Kai Shao, Min Luo
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New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. [PDF]
Clin Pharmacol Ther, 2022 Giacomini KM +9 more
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The roles of the human ATP-binding cassette transporters P-glycoprotein and ABCG2 in multidrug resistance in cancer and at endogenous sites: future opportunities for structure-based drug design of inhibitors. [PDF]
Cancer Drug Resist, 2021 Goebel J, Chmielewski J, Hrycyna CA.
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