Results 81 to 90 of about 1,767,276 (258)

Kinesin's backsteps under mechanical load [PDF]

, 2009
Kinesins move processively toward the plus end of microtubules by hydrolyzing ATP for each step. From an enzymatic perspective, the mechanism of mechanical motion coupled to the nucleotide chemistry is often well explained using a single-loop cyclic ...
Alberty, Alonso, Asbury, Baker, Beeg, Bell, Block, Block, Block, Brady, Brant, Carter, Changbong Hyeon, Chemla, Coppin, Coppin, Cross, Cross, Fisher, Fisher, Gelles, Gilbert, Gross, Guydosh, Hackney, Hackney, Howard, Hunt, Hyeon, Hyeon, Itoh, José N. Onuchic, Kawaguchi, Klumpp, Kojima, Kolomeisky, Liepelt, Liphardt, Lipowsky, Ma, Meyhofer, Mickler, Mori, Moyer, Muller, Nishiyama, Nishiyama, Oster, Qian, Qu, Reimann, Rice, Rice, Ross, Russell, Schief, Schief, Schnitzer, Schnitzer, Stefan Klumpp, Svoboda, Taniguchi, Thirumalai, Tsygankov, Uemura, Uemura, Vale, Vale, Visscher, Wu, Yildiz, Yildiz   +71 more
core   +1 more source

Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1

Science, 2019
ATP production under lockdown Cellular processes must respond to change, often by speeding up, slowing down, or stopping altogether. Adenosine triphosphate (ATP) synthases use a transmembrane proton gradient to produce ATP, but this reaction can go in ...
Jinke Gu, Laixing Zhang, Shuai Zong, R. Guo, Tianya Liu, J. Yi, Peiyi Wang, W. Zhuo, Maojun Yang   +8 more
semanticscholar   +1 more source

Presynaptic ATP Decreases During Physiological‐Like Activity in Neurons Tuned for High‐Frequency Transmission

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
We mainly used mice to express a FRET‐based ATP sensor in a subset of cerebellar mossy fibers. In acute brain slices, two‐photon FRET measurements at presynaptic cerebellar mossy fiber boutons were performed. Physiological‐like stimulation elicited a decrease in the presynaptic ATP concentration.
Isabelle Straub, Lukas Kunstmann, Felipe Baeza‐Lehnert, Saad Chowdhry, Robert B. Renden, Gerardo Gonzalez‐Aragón, Bernhard Groschup, Thomas Hofmann, Saša Jovanović, Mandy Sonntag, Daniel Gitler, Michael Schaefer, Jens Eilers, L. Felipe Barros, Johannes Hirrlinger, Stefan Hallermann   +15 more
wiley   +1 more source

Can the adenosine triphosphate (ATP) bioluminescence assay be used as an indicator for hospital cleaning? – A pilot study

GMS Hygiene and Infection Control
Background: In hospital cleaning, there is currently no standard for uniform monitoring of surface cleaning, either in Germany or internationally. One possibility for monitoring is the use of so-called objective methods for checking cleaning performance (
Niephaus, Valerie, Parohl, Nina, Heiligtag, Sabine, Reuter, Henning, Hackler, Reiner, Popp, Walter   +5 more
doaj   +1 more source

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]

, 2017
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov, Andrey Y. Abramov, Angelova, Bartolome, Bobba, Brand, Brown, Charles Arber, Ding, Edri, Elisavet Preza, Eva Carro, Fernando Bartolome, Ganote, Henry Houlden, Imamura, Johnson, Kokoszka, Krauss, Ludtmann, Macarena de Vicente, Marthe H.R. Ludtmann, Meyer, Muqit, Nalbandian, Nalbandian, Nalbandian, Okita, Papkovskaia, Plun-Favreau, Schirris, Selina Wray, Shi, Shi, Sonia Gandhi, Sposito, Vallier, Vieira, Weihl, Weinbach, Weydt, Wray, Yin, Zhivotovsky   +43 more
core   +2 more sources

Phosphate Improves Mitochondrial Function and Reduces Pancreatitis in Hypertriglyceridemia

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Phosphate protects against hypertriglyceridemia‐induced pancreatic injury by restoring calcium homeostasis and energy levels within acinar cells and shielding the pancreas from triglyceride‐induced inflammation, raising the possibility that phosphate supplementation may prevent or reduce the severity of pancreatitis.
Nidula Mullappilly, Sandip M. Swain, Joelle M.‐J. Romac, Husam Mikati, Rodger A. Liddle   +4 more
wiley   +1 more source

KIAA0753 promotes glucose and energy metabolism in osteoblasts inhibited by diabetes

陆军军医大学学报
Objective To explore the effect of KIAA0753 on glucose and energy metabolism in mouse embryonic osteoblast precursor cell line MC3T3-E1. Methods The GSE182286 datasets of patients with Joubert syndrome acquired from the Gene Expression Comprehensive ...
LI Mengxue, LI Mengxue, WANG Jichun, WANG Jichun, LI Letai   +4 more
doaj   +1 more source

BIOREMEDIATION OF CADMIUM CONTAMINATED WATER: BACTERIAL ACCUMULATION AND SURFACE COMPLEXITY BY REVIBACILLUS AGRI C15 AND BREVIBACILLUS AGRI C15 CDR [PDF]

مجلة الأنبار للعلوم الزراعية
Brevibacillus agri C15 and Brevibacillus agri C15 CdR have been reported as a tool for do uptake of cadmium (Cd). Nevertheless, it is unclear whether these strains contrast in their adsorption behaviors and surface complexation could be one of the ...
N. M. T. Jebril, A. K. Murad, R. Boden
doaj   +1 more source

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

Journal of Biological Chemistry, 2017
Partitioning of ATP generation between glycolysis and oxidative phosphorylation is central to cellular bioenergetics but cumbersome to measure. We describe here how rates of ATP generation by each pathway can be calculated from simultaneous measurements ...
S. Mookerjee, A. Gerencser, D. Nicholls, M. Brand   +3 more
semanticscholar   +1 more source

Non‐ionotropic NMDAR signalling activates Panx1 to induce P2X4R‐dependent long‐term depression in the hippocampus

The Journal of Physiology, Volume 603, Issue 15, Page 4367-4381, 1 August 2025.
Abstract figure legend Stimulation of the Shaffer collateral pathway at 3 Hz activates non‐ionotropic NMDA receptors. This subsequently leads to Src kinase mediated phosphorylation of pannexin‐1 (Panx1), which releases ATP from the postsynaptic cell. ATP acts as a ligand for P2X4 receptors to induce long‐term depression (LTD). Abstract In recent years,
Allison C. Nielsen, Connor L. Anderson, Carina Ens, Andrew K. J. Boyce, Roger J. Thompson   +4 more
wiley   +1 more source