ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Manuel Vicente +6 more
wiley +1 more source
Method of detecting and counting bacteria in body fluids [PDF]
A novel method is reported for determining bacterial levels in urine samples, which method depends on the quantitative determination of bacterial adenosine triphosphate (ATP) in the presence of non-bacterial ATP.
Chappelle, E. W., Picciolo, G. L.
core +1 more source
ATP-dependent chromatosome remodeling [PDF]
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Dimitrov S. +6 more
core +1 more source
Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1
ATP production under lockdown Cellular processes must respond to change, often by speeding up, slowing down, or stopping altogether. Adenosine triphosphate (ATP) synthases use a transmembrane proton gradient to produce ATP, but this reaction can go in ...
Jinke Gu +8 more
semanticscholar +1 more source
ATP mediates both activation and inhibition of K(ATP) channel activity via cAMP-dependent protein kinase in insulin-secreting cell lines. [PDF]
The single-channel recording technique was employed to investigate the mechanism conferring ATP sensitivity to a metabolite-sensitive K channel in insulin-secreting cells.
Ciani, S, Eddlestone, GT, Ribalet, B
core
Beneficial effects of PerformLyteTM, a prodosomed phytonutrient-enriched electrolyte formulation, in enhancing neuro-muscular synergy, immune competence, cellular aerobic glycolysis and sports performance [PDF]
An optimised sports nutrition formulation achieving the correct blend of electrolytes with antioxidants and vitamins is integral towards meeting the demanding performance in professional sports arena.
William Downs Bernard +7 more
doaj +1 more source
ATP Hydrolysis by α‐Synuclein Amyloids is Mediated by Enclosing β‐Strand
Pathological amyloids have been considered chemically inert until recently. Here it is shown that α‐synuclein amyloids catalyze the hydrolysis of the universal energy molecule, ATP. The cryo‐EM structure of the complex reveals an additional β‐strand (purple) that encloses the ATP‐binding site. Within the cavity, several lysine residues are required for
Lukas Frey +6 more
wiley +1 more source
Background: In hospital cleaning, there is currently no standard for uniform monitoring of surface cleaning, either in Germany or internationally. One possibility for monitoring is the use of so-called objective methods for checking cleaning performance (
Niephaus, Valerie +5 more
doaj +1 more source
ATP-Dependent Persister Formation in Escherichia coli
Persisters are dormant variants that form a subpopulation of cells tolerant to antibiotics. Persisters are largely responsible for the recalcitrance of chronic infections to therapy.
Yue Shan +5 more
semanticscholar +1 more source
Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis
During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial complex I subunits (Ndufa12), leading to suppressed cap‐dependent translation, reduced mitochondrial activity, and impaired innate immune responses.
Jaewhan Kim +9 more
wiley +1 more source

