Results 61 to 70 of about 969,519 (271)

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma [PDF]

, 2003
BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used
Pauline A Whitehouse, Federica Di Nicolantonio, Whitehouse, PA, Cree, IA, Bernard R Higgins, Di Nicolantonio Federica, Mercer Stuart J, Cree Ian A, Knight, LA, Higgins, BR, Osborne Richard, Kurbacher, CM, Kurbacher Christian M, Di Nicolantonio, Federica, Stuart J Mercer, Osborne, R, Richard Osborne, Alan Lamont, Whitehouse Pauline A, Louise A Knight, Sanjay Sharma, Di Nicolantonio, F, Neale Michael H, Andrew C Hindley, Hindley Andrew C, Sharma Sanjay, Knight Louise A, Lamont, A, Higgins Bernard R, Neale, MH, Ian A Cree, Hindley, AC, Mercer, SJ, Lamont Alan, Michael H Neale, Christian M Kurbacher, Sharma, S   +36 more
core   +1 more source

Distinct profiles of mitochondrial bioenergetics and redox balance in left atrial and ventricular myocardium in the healthy rat heart

Experimental Physiology, Volume 111, Issue 3, Page 1058-1068, 1 March 2026.
Abstract The left ventricle (LV) is the primary pumping chamber of the heart, generating high systolic pressure to sustain systemic circulation. LV contractile dysfunction is a hallmark of various cardiovascular diseases and is associated with mitochondrial dysfunction, characterised by decreased oxidative phosphorylation (OXPHOS) capacity and ...
Tingting Fang, Alex Chan, Janice Chew‐Harris, Toan Pham   +3 more
wiley   +1 more source

Beneficial effects of PerformLyteTM, a prodosomed phytonutrient-enriched electrolyte formulation, in enhancing neuro-muscular synergy, immune competence, cellular aerobic glycolysis and sports performance [PDF]

BIO Web of Conferences
An optimised sports nutrition formulation achieving the correct blend of electrolytes with antioxidants and vitamins is integral towards meeting the demanding performance in professional sports arena.
William Downs Bernard, Banik Samudra P., Morrison Bruce S., Chakraborty Tandra, Bagchi Manashi, Chakraborty Sanjoy, Kushner Steve, Bagchi Debasis   +7 more
doaj   +1 more source

ATP Cellotoxicity, ATP-Induced Cell Death and ATP Depletion

International Journal of Public Health and Medical Research
This paper delves into three pivotal themes concerning adenosine triphosphate (ATP): ATP cytotoxicity, ATP-induced cell death, and ATP depletion. Initially, we scrutinize ATP's involvement in cytotoxicity, with a specific focus on elucidating the mechanisms underlying cell demise triggered by augmented extracellular ATP concentrations. Subsequently, we
Haoling Zhang, Haolong Zhang, Rui Zhao, Doblin Sandai, Zhijing Song, Zhongwen Zhang, Wei Wang   +6 more
openaire   +1 more source

ATP-dependent DNA supercoiling assay.

, 2016
Supercoiling activities of DNA gyrases composed of WT-GyrA, Gly89Cys-GyrA, Ala91Val-GyrA or Asp95Gly-GyrA and WT-GyrB were confirmed. Relaxed pBR322 DNA was incubated with GyrA, GyrB, or both, of the subunits in the presence or absence of ATP.
Kazumasa Yokoyama (127298), Chie Nakajima (127312), Tomoyuki Yamaguchi (150399), Yasuhiko Suzuki (378)   +3 more
core   +1 more source

Deficiency of Microglial‐Derived Spp1 Exacerbates Age‐Related Memory Decline by Impairing Mitochondrial Complex I Function

Aging Cell, Volume 25, Issue 2, February 2026.
Microglia‐derived Spp1 regulates OXPHOS via the AKT/Complex I pathway to mitigate age‐related memory decline. (Graphical Abstract was created using BioRender). ABSTRACT Age‐related memory decline is a hallmark of brain aging and a primary risk factor for neurodegenerative disorders.
Meiling Wang, Yumin Chang, Aojie He, Jing Yang, Ang Li, Hongqin Wang, Kah‐Leong Lim, Xing Guo, Chengwu Zhang, Li Lu   +9 more
wiley   +1 more source

Photo‐Empowered Macrophage‐Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study develops a photo‐empowered macrophage‐based (PEM) drug delivery system that provides a novel and effective solution for restoring cellular motility to enhance drug delivery and overcome hypoxia‐induced multidrug resistance. The construction of the PEM system fully exploits the unique biological properties of macrophages and the energy ...
Zhaoming Fu, Xin Cui, Shanshan Liu, Lu Gao, Yingang Sun, Yujun Chen, Mianlong Li, Yuxin Fan, Jing Kuang, Wen Song, Feifan Zhou   +10 more
wiley   +1 more source

Effect of Transcutaneous Acupoint Electrical Stimulation on Urinary Retention and Urinary ATP in Elderly Patients After Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Trial

Clinical Interventions in Aging, 2022
Yanfang Zhang, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Xiangyun Li, Yan Guo, Simeng He, Xiaoyang Wu, Shasha Liu, Huayang Liu, Lantian Zhang, Jianbo Yu Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical
Zhang Y, Gong L, Zhang Y, Dong S, Shi J, Li X, Guo Y, He S, Wu X, Liu S, Liu H, Zhang L, Yu J   +12 more
doaj  

Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis [PDF]

, 2014
Type II DNA topoisomerases are essential enzymes that catalyze topological rearrangement of double-stranded DNA using the free energy generated by ATP hydrolysis.
Stanger, Frédéric V., Frédéric V Stanger, Tilman Schirmer, Dehio, Christoph, Schirmer, Tilman, Christoph Dehio, Frédéric V. Stanger (585551), Frédéric V. Stanger, Tilman Schirmer (585552), Christoph Dehio (200951)   +9 more
core   +1 more source

Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscular Connectivity in Barth Syndrome

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Barth syndrome (BTHS) is a rare X‐linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle weakness and fatigability are poorly
Catalina Matias, Paige L. Snider, Elizabeth A. Sierra Potchanant, Joshua R. Huot, Rahul Raghav, Michael T. Chin, Simon J. Conway, Jeffrey J. Brault   +7 more
wiley   +1 more source