Results 11 to 20 of about 9,465 (268)

Metal-dependent regulation of ATP7A and ATP7B in fibroblast cultures [PDF]

Frontiers in Molecular Neuroscience, 2016
Deficiency of one of the copper transporters ATP7A and ATP7B leads to the rare X-linked disorder Menkes Disease (MD) or the rare autosomal disorder Wilson disease (WD), respectively.
Lenartowicz Malgorzata, Torben Moos, Mateusz Ogorek, Thomas G Jensen, Lisbeth Birk Møller, Lisbeth Birk Møller   +5 more
doaj   +7 more sources

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction [PDF]

Advanced Science
Cardiac repair after myocardial ischemia–reperfusion (MIR) declines with aging. This study shows that Chromobox 7 (CBX7) acts in an age‐dependent manner, in young hearts, it promotes cardiomyocyte proliferation, whereas in aged hearts, CBX7 forms liquid ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
doaj   +3 more sources

Participation of ATP7A in macrophage mediated oxidation of LDL [PDF]

Journal of Lipid Research, 2010
ATP7A primarily functions to egress copper from cells, thereby supplying this cofactor to secreted copper-accepting enzymes. This ATPase has attracted significant attention since the discovery of its mutation leading to human Menkes disease and the ...
Zhenyu Qin, Eddy S. Konaniah, Bonnie Neltner, Raphael A. Nemenoff, David Y. Hui, Neal L. Weintraub   +5 more
doaj   +3 more sources

Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

Molecular Oncology, 2021
Cancer cells reprogram their copper metabolism to adapt to adverse microenvironments, such as oxidative stress. The copper chelator elesclomol has been reported to have considerable anticancer efficacy, but the underlying mechanisms remain largely ...
Wei Gao, Zhao Huang, Jiufei Duan, Edouard C. Nice, Jie Lin, Canhua Huang   +5 more
doaj   +2 more sources

Heterogeneous nuclear ribonucleoprotein hnRNPA2/B1 regulates the abundance of the copper-transporter ATP7A in an isoform-dependent manner

Frontiers in Molecular Biosciences, 2022
Copper (Cu) is an essential micronutrient with a critical role in mammalian growth and development. Imbalance of Cu causes severe diseases in humans; therefore, cellular Cu levels are tightly regulated.
Courtney J. McCann, Courtney J. McCann, Nesrin M. Hasan, Teresita Padilla-Benavides, Shubhrajit Roy, Svetlana Lutsenko   +5 more
doaj   +2 more sources

TRIM14 Regulation of Copper Homeostasis and Cuproptosis: A New Strategy to Overcome Chemoresistance in Glioblastoma [PDF]

Biomedicines
Background: Glioblastoma (GBM) is an aggressive primary brain tumor characterized by limited therapeutic options and poor prognosis. Temozolomide (TMZ) remains the standard chemotherapy; however, its effectiveness is often hindered by the development of ...
Jianyong Wang, Enhao Zhang, Siqi Chen, Haifeng Wang, Yi Huang, Wenting Lan   +5 more
doaj   +2 more sources

The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2

Nature Communications, 2021
The role of endothelial copper transporter ATP7A in vascular function and angiogenesis remains largely unexplored. Here the authors show that ATP7A promotes VEGFR2 signaling and angiogenesis by limiting autophagy-mediated degradation of VEGFR2, which ...
Dipankar Ash, Varadarajan Sudhahar, Seock-Won Youn, Mustafa Nazir Okur, Archita Das, John P. O’Bryan, Maggie McMenamin, Yali Hou, Jack H. Kaplan, Tohru Fukai, Masuko Ushio-Fukai   +10 more
doaj   +2 more sources

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The family of copper-dependent lysyl oxidase (LOX) enzymes contributes to tumor metastasis. In this study, we show that the ATP7A copper transporter is required to deliver copper to LOX family members.
Vinit Shanbhag, Kimberly J. Jasmer, Sha Zhu, Adam L. Martin, Nikita Gudekar, Aslam A. Khan, Erik Ladomersky, Kamlendra Singh, Gary A. Weisman, Michael J. Petris   +9 more
openalex   +2 more sources

Estimated birth prevalence of Menkes disease and ATP7A-related disorders based on the Genome Aggregation Database (gnomAD)

Molecular Genetics and Metabolism Reports, 2020
Background: Previous estimates of the prevalence of Menkes disease, a lethal X-linked recessive disorder of copper metabolism, were based on confirmed clinical cases ascertained from specific populations and varied from 1 in 40,000 to 1 in 354,507.
Stephen G. Kaler, Carlos R. Ferreira, Lung S. Yam   +2 more
doaj   +2 more sources

Alpha-synuclein null mutation exacerbates the phenotype of a model of Menkes disease in female mice [PDF]

Frontiers in Neuroscience
Human SNCA, which encodes a-synuclein protein (SNCA), was the first gene linked to familial Parkinson’s disease (PD). Since the discovery of the genetic link of SNCA to Parkinson’s nearly three decades ago, many studies have investigated the normal ...
MegAnne Casey, Dan Zou, Renee A. Reijo Pera, Tiffany Hensley-McBain, Deborah E. Cabin   +4 more
doaj   +2 more sources