Results 21 to 30 of about 5,775 (200)

Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC) [PDF]

Journal of Translational Medicine, 2012
Background Copper export protein ATP7A is important for maintaining copper homeostasis. Recent studies have shown that copper transporters are also involved in the transport of platinum.
Li Zhuang-hua, Qiu Miao-zhen, Zeng Zhao-lei, Luo Hui-yan, Wu Wen-jing, Wang Feng, Wang Zhi-qiang, Zhang Dong-sheng, Li Yu-hong, Xu Rui-hua   +9 more
doaj   +2 more sources

ATP7A-mediated copper ion efflux reprogrammes tumour immunity and promotes cisplatin resistance in cervical cancer [PDF]

Cell Death and Disease
Cisplatin resistance is a major obstacle to effective chemotherapy in patients with cervical cancer and is associated with an immunosuppressive tumour microenvironment.
Shuangjia Pan, Qianqian Wu, Hejing Liu, Yujia Zhou, Jiayi Ruan, Yuqing Jin, Lingxiao Huang, Jian’an Zhang, Huihui Ji, Xueqiong Zhu   +9 more
doaj   +2 more sources

Integrated Transcriptomic and Single-Cell Analyses Link ATP7A, a Cuproptosis-Related Hub Gene, to ECM-Adhesion Signaling Dysfunction in UVB-Induced Skin Photodamage [PDF]

Clinical, Cosmetic and Investigational Dermatology
Shiyang Li,1,2 Wei Wan,3 Ting Meng,1,2 Jie Zhang,1,2 Yu Xiao,1,2 Xianwei Cao1,2 1Department of Dermatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, People’s Republic of China; 2Institute of Dermatology ...
Li S, Wan W, Meng T, Zhang J, Xiao Y, Cao X   +5 more
doaj   +2 more sources

ATP7A-fibulin-4 complex delivers copper in the Golgi to activate LOX in renal fibrosis [PDF]

JCI Insight
Lysyl oxidase (LOX) is a copper-dependent monoamine oxidase whose primary function is the covalent cross-linking of collagen and elastin in the extracellular matrix (ECM).
Wenqian Zhou, Yan Zheng, Yuqing Liu, Jing Liu, Yiguo Liu, Yangyang Niu, Ying Yu, Xiaoqin Zhang, Yingying Zhang, Chen Yu   +9 more
doaj   +2 more sources

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity [PDF]

Journal of Biological Chemistry, 2009
Copper is an essential micronutrient that is necessary for healthy immune function. This requirement is underscored by an increased susceptibility to bacterial infection in copper-deficient animals; however, a molecular understanding of its importance in immune defense is unknown.
White, Carine, Lee, Jaekwon, Kambe, Taiho, Fritsche, Kevin, Petris, Michael J.   +4 more
openaire   +4 more sources

Platination of the copper transporter ATP7A involved in anticancer drug resistance

Dalton Transactions, 2014
The clinical efficacy of the widely used anticancer drug cisplatin is severely limited by the emergence of resistance. This is related to the drug binding to proteins such as the copper influx transporter Ctr1, the copper chaperone Atox1, and the copper pumps ATP7A and ATP7B. While the binding modes of cisplatin to the first two proteins are known, the
Calandrini V, Galliani A, Nguyen TH, Ippoliti E, Carloni P, ARNESANO, FABIO, NATILE, Giovanni   +6 more
core   +5 more sources

TRIM14 Regulation of Copper Homeostasis and Cuproptosis: A New Strategy to Overcome Chemoresistance in Glioblastoma [PDF]

Biomedicines
Background: Glioblastoma (GBM) is an aggressive primary brain tumor characterized by limited therapeutic options and poor prognosis. Temozolomide (TMZ) remains the standard chemotherapy; however, its effectiveness is often hindered by the development of ...
Jianyong Wang, Enhao Zhang, Siqi Chen, Haifeng Wang, Yi Huang, Wenting Lan   +5 more
doaj   +2 more sources

Copper-Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF-α/ATP7A Axis. [PDF]

Adv Sci (Weinh)
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xiao X, Hao Y, Ding Z, Wang Z, Shi Y, Huang Y, Qi C, Zhang Q.   +7 more
europepmc   +2 more sources

Novel ATP7A gene mutation in a patient with Menkes disease

The Application of Clinical Genetics, 2018
Gabriela Caicedo-Herrera,1 Estephania Candelo,1 Juan Pinilla,2 Andrés Vidal,2 Santiago Cruz,3 Harry Mauricio Pachajoa1–4 1Health Sciences Faculty, Universidad Icesi, Cali, Colombia; 2Dermatology, Fundación Valle Del Lili, Cali ...
Caicedo-Herrera G, Candelo E, Pinilla J, Vidal A, Cruz S, Pachajoa HM   +5 more
doaj   +1 more source

ATP7A-dependent copper sequestration contributes to termination of β-CATENIN signaling during early adipogenesis [PDF]

Molecular Metabolism
Objectives: Adipocyte fate determination is tightly regulated by extrinsic signaling pathways and intrinsic metabolic and morphologic changes that maintain adipose tissue function.
H. Yang, E. Kabin, Y. Dong, X. Zhang, M. Ralle, S. Lutsenko   +5 more
doaj   +2 more sources